Results 51 to 60 of about 4,980,963 (235)

Supplementary material for "Promoting Nrf2/Sirt3-dependent mitophagy suppresses apoptosis in nucleus pulposus cells and protects against intervertebral disc degeneration"

, 2020
Supplementary material for "Promoting Nrf2/Sirt3-dependent mitophagy suppresses apoptosis in nucleus pulposus cells and protects against intervertebral disc ...
Wang, X (via Mendeley Data)
core   +1 more source

Single-cell RNA-seq analysis reveals the Wnt/Ca2+ signaling pathway with inflammation, apoptosis in nucleus pulposus degeneration

BMC Musculoskeletal Disorders
Background Increasing studies have shown degeneration of nucleus pulposus cells (NPCs) as an critical part of the progression of intervertebral disc degeneration (IVDD).
Peigeng Wang, Zhencong Li, Dongping Ye
doaj   +1 more source

A Decoy‐Receptor‐Armed Biomimetic Nanotherapeutic With Inherent Tropism for Conserved Pathogenic Macrophages for Treating Osteoarthritis and Intervertebral Disc Degeneration

Advanced Science, EarlyView.
A biomimetic doppelgänger nanosystem neutralizes extracellular inflammatory cytokines and silences intracellular pyroptosis, reprogramming pathogenic macrophages to attenuate both joint and spine degeneration. ABSTRACT Osteoarthritis (OA) and intervertebral disc degeneration (IVDD) are debilitating musculoskeletal disorders driven by shared ...
Fudong Li, Bin Zhang, Zhiqiu Zhang, Bing Zheng, Linhui Han, Chen Yan, Jialin Li, Kaiqiang Sun, Tianyi Zhao, Jiangang Shi   +9 more
wiley   +1 more source

Transforming growth factor β controls CCN3 expression in nucleus pulposus cells of the intervertebral disc [PDF]

, 2011
Objective To investigate transforming growth factor β (TGFβ) regulation of CCN3 expression in cells of the nucleus pulposus. Methods Real‐time reverse transcription–polymerase chain reaction and Western blot analyses were used to measure CCN3 ...
Rittié, Laure, Symes, Aviva, Irving M. Shapiro, Risbud, Makarand V., Makarand V. Risbud, Cassie M. Tran, Bernard Perbal, Shapiro, Irving M., Smith, Harvey E., Harvey E. Smith, Perbal, Bernard, Laure Rittié, Tran, Cassie M., Aviva Symes   +13 more
core   +1 more source

TGF-β Induces Up-Regulation of Chondroitin Sulfate Synthase 1 (CHSY1) in Nucleus Pulposus Cells Through MAPK Signaling

Cellular Physiology and Biochemistry, 2015
Background/Aims: Chondroitin sulfate synthase 1 (CHSY1) is a glycosyltransferases involved in the biosynthesis of chondroitin and dermatan sulfate glycosaminoglycan (GAG).
Bo Hu, Changgui Shi, Ye Tian, Ying Zhang, Chen Xu, Huajiang Chen, Peng Cao, Wen Yuan   +7 more
doaj   +1 more source

ROS‐Responsive Eye Drop for Controlled Release of 20‐Deoxyingenol Improves Diabetic Corneal Healing by Activating Macrophage Autophagy and Metabolic Reprogramming

Advanced Science, EarlyView.
Schematic illustration of ROS‐responsive TSPBA‐PVA microspheres loaded with 20‐deoxyingenol (TP/20‐DOI) for diabetic corneal wound healing: (a) fabrication and ROS‐triggered release; (b) autophagy activation and metabolic reprogramming in macrophages; (c) suppression of macrophage‐derived CXCL3/CXCL5, attenuation of neutrophil infiltration, and ...
Jiaxin Wu, Wanying Chen, Haijiang Qiu, Weihan Zheng, Ying Jiao, Jingheng Du, Zhudan Zhuang, Xing Hua, Jingyi Gu, Yuheng Liu, Zhaojin Li, Jingbin Xie, Hanxiao Sun, Huifei Lan, Xin Sun, Yunxia Xue, Ting Fu, Zhijie Li, Guobing Chen, Shiyu Li, Jun Liu   +20 more
wiley   +1 more source

Harmonization and standardization of nucleus pulposus cell extraction and culture methods

JOR SPINE, 2023
AbstractBackgroundIn vitro studies using nucleus pulposus (NP) cells are commonly used to investigate disc cell biology and pathogenesis, or to aid in the development of new therapies. However, lab‐to‐lab variability jeopardizes the much‐needed progress in the field.
Basatvat, Shaghayegh, Bach, Frances C., Barcellona, Marcos N., Binch, Abbie L., Buckley, Conor T., Bueno, Brian, Chahine, Nadeen O., Chee, Ana, Creemers, Laura B., Dudli, Stefan, Fearing, Bailey, Ferguson, Stephen J., Gansau, Jennifer, Gantenbein, Benjamin, Gawri, Rahul, Glaeser, Juliane D., Grad, Sibylle, Guerrero, Julien, Haglund, Lisbet, Hernandez, Paula A., Hoyland, Judith A., Huang, Charles, Iatridis, James C., Illien‐Junger, Svenja, Jing, Liufang, Kraus, Petra, Laagland, Lisanne T., Lang, Gernot, Leung, Victor, Li, Zhen, Lufkin, Thomas, van Maanen, Josette C., McDonnell, Emily E., Panebianco, Chris J., Presciutti, Steven M., Rao, Sanjna, Richardson, Stephen M., Romereim, Sarah, Schmitz, Tara C., Schol, Jordy, Setton, Lori, Sheyn, Dmitriy, Snuggs, Joseph W., Sun, Y., Tan, Xiaohong, Tryfonidou, Marianna A., Vo, Nam, Wang, Dong, Williams, Brandon, Williams, Rebecca, Yoon, S. Tim, Le Maitre, Christine L.   +51 more
openaire   +7 more sources

BMSCs-derived exosomes overexpressing TGM2 inhibit lactate-induced oxidative stress related apoptosis in nucleus pulposus cells

陆军军医大学学报
Objective To explore the role and mechanism of exosomes derived from bone marrow mesenchymal stem cells (BMSCs) overexpressing transglutaminase 2 (TGM2) in lactate-mediated oxidative stress-induced apoptosis in nucleus pulposus cells.
LOU Jinhui, GAO Xiaoxin, ZHANG Yuyao
doaj   +1 more source

Dual‐Gene Edited Extracellular Vesicles Remodel the Redox Homeostasis to Inhibit Ferroptosis in Intervertebral Disc Degeneration

Advanced Science, EarlyView.
ABSTRACT Intervertebral disc degeneration (IDD) is driven by ferroptosis of nucleus pulposus cells (NPCs) as a core pathological mechanism. Nucleus pulposus progenitor cells (NPPCs), exhibiting stem cell‐like properties, yield extracellular vesicles (PEVs) with high affinity for NPCs and enable targeted phenotypic regulation.
Jing Yan, Yazhou Lin, Shuo Miao, Minghao Chao, Chengbai Dai, Ziwen Hao, Rui Chen, Ming Guan, Bin Pan, Fenglei Gao, Quan Zhou   +10 more
wiley   +1 more source

Inhibition of the Notch1 Pathway Promotes the Effects of Nucleus Pulposus Cell-Derived Exosomes on the Differentiation of Mesenchymal Stem Cells into Nucleus Pulposus-Like Cells in Rats [PDF]

Stem Cells International, 2019
Stem cell therapies for intervertebral disc degeneration have been demonstrated as a promising strategy. Previous studies have shown that human nucleus pulposus cell- (NPC-) derived exosomes can induce the differentiation of mesenchymal stem cells (MSCs) into NP-like cells in vitro.
Wei-ren Lan, Sai Pan, Hai-yin Li, Chao Sun, Xian Chang, Kang Lu, Chang-qing Jiang, Rui Zuo, Yue Zhou, Chang-qing Li   +9 more
openaire   +3 more sources