Results 41 to 50 of about 4,980,963 (235)

MiR-532 downregulation of the Wnt/β-catenin signaling via targeting Bcl-9 and induced human intervertebral disc nucleus pulposus cells apoptosis

Journal of Pharmacological Sciences, 2018
Objective: Intervertebral disc degeneration was characterized with aberrant intervertebral disc nucleus pulposus cells apoptosis. MiR-532 was reported to be up-regulated in the patients with intervertebral disc degeneration.
Zeyu Sun, Yuekui Jian, Hongying Fu, Bo Li   +3 more
doaj   +1 more source

Towards Tissue-Specific Stem Cell Therapy for the Intervertebral Disc: PPARδ Agonist Increases the Yield of Human Nucleus Pulposus Progenitor Cells in Expansion [PDF]

, 2021
(1) Background: Low back pain (LBP) is often associated with intervertebral disc degeneration (IVDD). Autochthonous progenitor cells isolated from the center, i.e., the nucleus pulposus, of the IVD (so-called nucleus pulposus progenitor cells (NPPCs ...
Guerrero, Julien, Croft, Andreas, Gantenbein, Benjamin, Albers, Christoph E., Andreas Croft, Albers, Christoph, Zhang, Xingshuo, Häckel, Sonja, Christoph Albers, Oswald, Katharina, Benjamin Gantenbein, Croft, Andreas S., Xingshuo Zhang, Katharina Oswald, Sonja Häckel, Julien Guerrero, Oswald, Katharina A.C., Christoph E. Albers, Katharina A.C. Oswald, Andreas S. Croft   +19 more
core   +2 more sources

Cationic Polymer Brush-Modified Carbon Nanotube-Meditated eRNA LINC02569 Silencing Attenuates Nucleus Pulposus Degeneration by Blocking NF-κB Signaling Pathway and Alleviate Cell Senescence

Frontiers in Cell and Developmental Biology, 2022
Enhancer RNAs (eRNAs) are noncoding RNAs that synthesized at active enhancers. eRNAs have important regulatory characteristics and appear to be significant for maintenance of cell identity and information processing.
Yulin Huang, Jiaming Yang, Xizhe Liu, Xiaoshuai Wang, Kai Zhu, Zemin Ling, Baozhu Zeng, Ningning Chen, Shaoyu Liu, Fuxin Wei   +9 more
doaj   +1 more source

Inhibition of the P53/P21 Pathway Attenuates the Effects of Senescent Nucleus Pulposus Cell‐Derived Exosomes on the Senescence of Nucleus Pulposus Cells [PDF]

Orthopaedic Surgery, 2020
ObjectiveThe purpose of this paper is to investigate the effects of senescent nucleus pulposus cell (NPC)‐derived exosomes (SNPC‐Exo) and the roles of the P53/P21 pathway on the senescence of NPC.MethodsThe senescent phenotypes of NPC were induced by interleukin‐1β treatment.
Chang‐chun Chen, Jing Chen, Wen‐liang Wang, Liang Xie, Chuan‐qiang Shao, Yan‐xiang Zhang   +5 more
openaire   +3 more sources

Supplementary Material for: Lentivirus-shRNA mediated prolyl hydroxylase 2 knockdown increases HIF-1α and inhibits nucleus pulposus cells degeneration

, 2021
Hypoxia-inducible factor (HIF) plays a crucial role in regulating the hypoxia-inducible state of nucleus pulposus cells in the intervertebral disc. In addition, the oxygen-dependent conversion of HIF-1α in nucleus pulposus cells is controlled by the ...
Shi F. (11705888), Mao G. (11705891), Yang X. (3341028), Yang C. (4140691), Zhou C. (3333507), Chen Q. (3335055), Liu L. (2945928), Song Y. (3137490)   +7 more
core   +2 more sources

The evolutionary importance of cell ratio between notochordal and nucleus pulposus cells: an experimental 3-D co-culture study [PDF]

, 2011
Notochordal cells and nucleus pulposus cells are co-existing in the intervertebral disc at various ratios among different mammalians. This fact rises the question about the interactions and the evolutionary relevance of this phenomenon.
Chan, Samantha C W, Benjamin Gantenbein-Ritter, Gantenbein-Ritter, Benjamin, Samantha C. W. Chan, Gantenbein-Ritter B, Chan SC   +5 more
core   +2 more sources

Angiopoietin-1 receptor Tie2 distinguishes multipotent differentiation capability in bovine coccygeal nucleus pulposus cells. [PDF]

, 2016
BACKGROUND The intervertebral disc (IVD) has limited self-healing potential and disc repair strategies require an appropriate cell source such as progenitor cells that could regenerate the damaged cells and tissues.
Daisuke Sakai, Benjamin Gantenbein, Grad, Sibylle, Adel Tekari, Gantenbein, Benjamin, Sakai, Daisuke, Samantha C. W. Chan, Tekari, Adel, Sibylle Grad, Chan, Samantha C.W., Chan SCW, Tekari A, Chan, Samantha C. W. (author), Gantenbein B, Sakai D, Tekari, Adel (author), Sakai, Daisuke (author), Grad, Sibylle (author), Gantenbein, Benjamin (author), Grad S   +19 more
core   +2 more sources

Hemeoxygenase-1 Suppresses IL-1β-Induced Apoptosis Through the NF-κB Pathway in Human Degenerative Nucleus Pulposus Cells

Cellular Physiology and Biochemistry, 2018
Background/Aims: Nucleus pulposus cell (NPC) apoptosis is the main factor in intervertebral disc degeneration (IDD); thus, inhibiting the excessive apoptosis of nucleus pulposus cells may be a potential way to alleviate IDD. The effect of Hemeoxygenase-1
Chaoying Zhu, Wei Jiang, Qiang Cheng, Zhenming Hu, Jie Hao   +4 more
doaj   +1 more source

Hypoxic Regulation of Nucleus Pulposus Cell Survival [PDF]

The American Journal of Pathology, 2010
This minireview examines the role of hypoxia, and hypoxia inducible factors (HIF-1 and HIF-2), in regulating the metabolism, function, and fate of cells of the nucleus pulposus in the intervertebral disk. We focus on the mechanisms by which both these hypoxia-sensitive transcription factors influence energy metabolism, radical dismutation, and ...
Makarand V, Risbud, Ernestina, Schipani, Irving M, Shapiro   +2 more
openaire   +2 more sources

Role of Embinin in the reabsorption of nucleus pulposus in lumbar disc herniation: Promotion of nucleus pulposus neovascularization and apoptosis of nucleus pulposus cells

Open Life Sciences
Abstract Reabsorption of the nucleus pulposus (NP) in lumbar disc herniation (LDH) refers to the natural absorption or even complete disappearance of LDH. In order to better treat LDH, it is necessary to further study its mechanism and develop new therapeutic drugs.
Meng, Yingying, Liu, Wei, Liu, Haifeng, Yu, Chengwei   +3 more
openaire   +3 more sources