Results 41 to 50 of about 12,120 (223)

In Vitro Characterization of a Tissue Renin-Angiotensin System in Human Nucleus Pulposus Cells [PDF]

, 2022
Low back pain is a clinically highly relevant musculoskeletal burden and is associated with inflammatory as well as degenerative processes of the intervertebral disc.
Alini, Mauro, Gernot Lang, Saravi, Babak E., Li, Zhen, Peter Obid, Lang, Gernot, Albers, Christoph E., Mauro Alini, Albers, Christoph E, Zhen Li, Sibylle Grad, Häckel, Sonja, Christoph E. Albers, Valentina Basoli, Babak Saravi, Hagen Schmal, Saravi, Babak, Obid, Peter, Grad, Sibylle, Schmal, Hagen, Sonja Häckel, Basoli, Valentina   +21 more
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Conditioned medium derived from notochordal cell-rich nucleus pulposus tissue stimulates matrix production by canine nucleus pulposus cells and bone marrow-derived stromal cells. [PDF]

, 2015
Objectives: Conditioned medium derived from notochordal cell-rich nucleus pulposus tissue (NCCM) was previously shown to have a stimulatory effect on bone marrow stromal cells (BMSCs) and nucleus pulposus cells (NPCs) individually, in mixed species in ...
Potier, Esther, LS Algemene chirurgie, dCSCA AVR, Meij, Björn, Potier, E Esther, de Vries, Stefan A.H., Tryfonidou, M.A., Meij, Björn P, Vries, SAH Stefan de, de Vries, Stefan A H, Doeselaar, M van, dCSCA RMSC-1, Vries, de, S.A.H., Ito, K Keita, Applied Veterinary Research, Meij, B.P., Orthopedie en neurochirurgie, Ito, K., Ito, K, Potier, E., Ito, Keita, Tryfonidou, Marianna A, Doeselaar, van, M., Regenerative Medicine, Stem Cells & Cancer, van Doeselaar, Marina, Meij, BP, Tryfonidou, MA, Tryfonidou, Marianna   +27 more
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Influence of Age-Related Degeneration on Regenerative Potential of Human Nucleus Pulposus Cells

, 2011
Nucleus pulposus (NP) cells, sourced from herniation surgeries, may be used as a cell-based therapy for intervertebral disc (IVD) degeneration. But, both the regenerative potential of these degenerative adult NP cells and how to stimulate optimum matrix ...
楊曙華;林鎮江;胡名孝;施庭芳;孫元蕙;林峰輝, YANG, SHU-HUA;LIN, CHEN-CHIANG;HU, MING-HSIAO;SHIH, TIFFANY TING-FANG;SUN, YUAN-HUI;LIN, FENG- HUEI;LIN, FENG-HUEI   +1 more
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Effect of different cryopreservation media on human nucleus pulposus cells' viability and trilineage potential [PDF]

, 2021
Introduction: Low back pain (LBP) is a significant cause of disability in many countries, affecting more than half a billion people worldwide. In the past, progenitor cells have been found within the nucleus pulposus (NP) of the human intervertebral disc
Guerrero, Julien, Oswald, Katharina A. C., Katharina A. C. Oswald, Gantenbein, Benjamin, Albers, Christoph E., Albers, Christoph E, Häckel, Sonja, Christoph E. Albers, Benjamin Gantenbein, Croft, Andreas S., Oswald, Katharina A C, Andreas S. Croft, Sonja Häckel, Julien Guerrero   +13 more
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Hyperosmolar expansion medium improves nucleus pulposus cell phenotype

JOR SPINE, 2022
AbstractBackgroundRepopulating the degenerated intervertebral disc (IVD) with tissue‐specific nucleus pulposus cells (NPCs) has already been shown to promote regeneration in various species. Yet the applicability of NPCs as cell‐based therapy has been hampered by the low cell numbers that can be extracted from donor IVDs and their potentially limited ...
Laagland, Lisanne T., Bach, Frances C., Creemers, Laura B., Le Maitre, Christine L., Poramba‐Liyanage, Deepani W., Tryfonidou, Marianna A.   +5 more
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Successful fishing for nucleus pulposus progenitor cells of the intervertebral disc across species [PDF]

, 2018
Background context: Recently, Tie2/TEK receptor tyrosine kinase (Tie2 or syn. Ang-1 angiopoetin-1 receptor) positive nucleus pulposus progenitor cells were detected in human, cattle and mouse.
Nakamura, Yoshihiko, Daniela A. Frauchiger, Rahel D. May, Gantenbein, Benjamin, Sakai, Daisuke, Grad, S., May, Rahel D, Creemers, L. B., Tryfonidou, Marianna A., Tomoko Nakai, Benjamin Gantenbein, Creemers, Laura B.; id_orcid, Bach, F. C., Laura B. Creemers, Bach, Frances C., Sakai, D., Frances C. Bach, Sagawa, Nobuho, Nakai, T., Nobuho Sagawa, Sagawa, N., Frauchiger, Daniela A, Watanabe, Masahiko, Sibylle Grad, Masahiko Watanabe, Chan, Samantha C.W., Orthopedie en neurochirurgie, Marianna A. Tryfonidou, May, Rahel D., Tryfonidou, Marianna A, Jordy Schol, Bach, Frances C, Tekari, A., Creemers, Laura B, Yoshihiko Nakamura, Schol, J., Tryfonidou, M. A., Daisuke Sakai, Frauchiger, Daniela A., Nakamura, Y., dCSCA RMSC-1, Samantha C.W. Chan, Chan, Samantha C W, Schol, Jordy, Tekari, Adel, Nakai, Tomoko, Grad, Sibylle, Adel Tekari, Chan, Samantha, Frauchiger, Daniela Angelika, May, Rahel Deborah   +50 more
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Role of Embinin in the reabsorption of nucleus pulposus in lumbar disc herniation: Promotion of nucleus pulposus neovascularization and apoptosis of nucleus pulposus cells

Open Life Sciences
Abstract Reabsorption of the nucleus pulposus (NP) in lumbar disc herniation (LDH) refers to the natural absorption or even complete disappearance of LDH. In order to better treat LDH, it is necessary to further study its mechanism and develop new therapeutic drugs.
Meng, Yingying, Liu, Wei, Liu, Haifeng, Yu, Chengwei   +3 more
openaire   +3 more sources

Exhaustion of nucleus pulposus progenitor cells with ageing and degeneration of the intervertebral disc. [PDF]

, 2012
Despite the high prevalence of intervertebral disc disease, little is known about changes in intervertebral disc cells and their regenerative potential with ageing and intervertebral disc degeneration.
Mishima, Taishi, Alini, Mauro, Nakamura, Yoshihiko, Cheah, Kathryn SE, Mochida, Joji, Sakai, Daisuke, Risbud, Makarand V, Kato, Shunichi, Nakai, Tomoko, Chan, Danny, Grad, Sibylle, Masuda, Koichi, Cheah, Kathryn S E, Yamamura, Ken-ichi, Ando, Kiyoshi, Okano, Hideyuki   +15 more
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The Stimulatory Effect of Notochordal-Cell Conditioned Medium in a Nucleus Pulposus Explant Culture [PDF]

, 2015
OBJECTIVES: Notochordal cell-conditioned medium (NCCM) has previously shown to have a stimulatory effect on nucleus pulposus cells (NPCs) and bone marrow stromal cells (BMSCs) in alginate and pellet cultures.
dCSCA RMSC-1, Doeselaar, Marina van, Sub Neuro/Tandheelkunde, de Vries, Stefan, Ito, Keita, dCSCA AVR, Meij, Björn, Tryfonidou, M, Regenerative Medicine, Stem Cells & Cancer, CSCA TR1   +9 more
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Single-cell RNA-seq analysis reveals the Wnt/Ca2+ signaling pathway with inflammation, apoptosis in nucleus pulposus degeneration

BMC Musculoskeletal Disorders
Background Increasing studies have shown degeneration of nucleus pulposus cells (NPCs) as an critical part of the progression of intervertebral disc degeneration (IVDD).
Peigeng Wang, Zhencong Li, Dongping Ye
doaj   +1 more source