Results 31 to 40 of about 12,120 (223)

The evolutionary importance of cell ratio between notochordal and nucleus pulposus cells: an experimental 3-D co-culture study [PDF]

, 2011
Notochordal cells and nucleus pulposus cells are co-existing in the intervertebral disc at various ratios among different mammalians. This fact rises the question about the interactions and the evolutionary relevance of this phenomenon.
Chan, Samantha C W, Benjamin Gantenbein-Ritter, Gantenbein-Ritter, Benjamin, Samantha C. W. Chan   +3 more
core   +1 more source

MiR-532 downregulation of the Wnt/β-catenin signaling via targeting Bcl-9 and induced human intervertebral disc nucleus pulposus cells apoptosis

Journal of Pharmacological Sciences, 2018
Objective: Intervertebral disc degeneration was characterized with aberrant intervertebral disc nucleus pulposus cells apoptosis. MiR-532 was reported to be up-regulated in the patients with intervertebral disc degeneration.
Zeyu Sun, Yuekui Jian, Hongying Fu, Bo Li   +3 more
doaj   +1 more source

Expansion of FGFR3-positive nucleus pulposus cells plays important roles in postnatal nucleus pulposus growth and regeneration

Stem Cell Research & Therapy, 2022
AbstractBackgroundIntervertebral disc degeneration (IVDD) can cause low back pain, a major public health concern. IVDD is characterized with loss of cells especially those in nucleus pulposus (NP), due to the limited proliferative potential and regenerative ability.
Meng Xu, Junlan Huang, Min Jin, Wanling Jiang, Fengtao Luo, Qiaoyan Tan, Ruobin Zhang, Xiaoqing Luo, Liang Kuang, Dali Zhang, Sen Liang, Huabing Qi, Hangang Chen, Zhenhong Ni, Nan Su, Jing Yang, Xiaolan Du, Bo Chen, Chuxia Deng, Yangli Xie, Lin Chen   +20 more
openaire   +3 more sources

Influence of different commercial scaffolds on the in vitro differentiation of human mesenchymal stem cells to nucleus pulposus-like cells [PDF]

, 2011
Introduction Cell-based therapies for regeneration of the degenerated intervertebral disc (IVD) are an alternative to current surgical intervention. Mesenchymal stem cells (MSCs), in combination with a scaffold, might be ideal candidates for regenerating
Baur, Martin, Niklaus Aebli, Martin Baur, Stoyanov, Jivko V, V. Stoyanov, Jivko, Bertolo, Alessandro, Jivko V. Stoyanov, Ferguson, Stephen J, Ferguson, Stephen J., Ferguson, Stephen John, Stephen J. Ferguson, Stoyanov, Jivko V., J. Ferguson, Stephen, Mehr, Marco, Aebli, Nikolaus, Aebli, Niklaus, Alessandro Bertolo, Marco Mehr   +17 more
core   +1 more source

Effect of electroacupuncture at “Jiaji” （EX-B2） on senescence of nucleus pulposus cells of degenerated lumbar intervertebral disc in rabbits

针刺研究, 2023
ObjectiveTo observe the effect of electroacupuncture （EA） at “Jiaji”（EX-B2） on body mass， motor function， expression of caveolin-1 （Cav-1） in nucleus pulposus cells and annulus fibrosus tissue， telomerase activi-ty， relative telomere length and different
ZHANG Yan-lin, ZOU Jing, WANG Min, WANG Kun-xiu, HUANG Guo-fu   +4 more
doaj  

Cationic Polymer Brush-Modified Carbon Nanotube-Meditated eRNA LINC02569 Silencing Attenuates Nucleus Pulposus Degeneration by Blocking NF-κB Signaling Pathway and Alleviate Cell Senescence

Frontiers in Cell and Developmental Biology, 2022
Enhancer RNAs (eRNAs) are noncoding RNAs that synthesized at active enhancers. eRNAs have important regulatory characteristics and appear to be significant for maintenance of cell identity and information processing.
Yulin Huang, Jiaming Yang, Xizhe Liu, Xiaoshuai Wang, Kai Zhu, Zemin Ling, Baozhu Zeng, Ningning Chen, Shaoyu Liu, Fuxin Wei   +9 more
doaj   +1 more source

Nucleus pulposus cell-matrix interactions with laminins

European Cells and Materials, 2011
The cells of the nucleus pulposus (NP) region of the intervertebral disc play a critical role in this tissue's generation and maintenance, and alterations in NP cell viability, metabolism, and phenotype with aging may be key contributors to progressive disc degeneration.
CL Gilchrist, AT Francisco, GE Plopper, J Chen, LA Setton   +4 more
openaire   +3 more sources

Inhibition of the P53/P21 Pathway Attenuates the Effects of Senescent Nucleus Pulposus Cell‐Derived Exosomes on the Senescence of Nucleus Pulposus Cells [PDF]

Orthopaedic Surgery, 2020
ObjectiveThe purpose of this paper is to investigate the effects of senescent nucleus pulposus cell (NPC)‐derived exosomes (SNPC‐Exo) and the roles of the P53/P21 pathway on the senescence of NPC.MethodsThe senescent phenotypes of NPC were induced by interleukin‐1β treatment.
Chang‐chun Chen, Jing Chen, Wen‐liang Wang, Liang Xie, Chuan‐qiang Shao, Yan‐xiang Zhang   +5 more
openaire   +3 more sources

Inhibition of the extracellular signal-regulated kinase pathway reduces the inflammatory component in nucleus pulposus cells. [PDF]

, 2022
Intervertebral disc (IVD) degeneration is a spinal disorder that triggers an inflammatory response and subsequent development of spinal pseudoarthrosis.
Crump, Katherine, Bermudez-Lekerika, Paola, Katherine Crump, Benjamin Gantenbein, Marazza|, Adel Tekari, Gantenbein, Benjamin, Marazza, Alessandro, Alessandro Marazza, Bermudez‐Lekerika, Paola, Tekari, Adel, Paola Bermudez‐Lekerika   +11 more
core   +1 more source

Role of PI3K/AKT Signaling Pathway in Nucleus Pulposus Cells [PDF]

BioMed Research International, 2021
Objective. To investigate the role of PI3K/AKT signaling pathway in nucleus pulposus (NP) cells. Methods. Nucleus pulposus (NP) cells were isolated from SD rat, and thereafter, passage three (P3) NP cells were divided into the following experimental groups: control, PI3K/AKT agonist IGF‐1 (25 ng/ml, 50 ng/ml, and 100 ng/ml), and PI3K/AKT inhibitor ...
Quan Xiao, Yun Teng, Changming Xu, Wei Pan, Hanshi Yang, Jiali Zhao, Quan Zhou   +6 more
openaire   +2 more sources