Results 31 to 40 of about 4,980,963 (235)

The Regenerative Potential of Notochordal Cells in a Nucleus Pulposus Explant [PDF]

Global Spine Journal, 2017
Study Design In vitro disk explant culture. Objective Notochordal cells (NCs) have been shown to upregulate matrix production by nucleus pulposus (NP) cells in coculture.
Arkesteijn, Irene, Potier, Esther, Ito, Keita   +2 more
openaire   +2 more sources

Hypoxia-induced expression of zinc finger protein A20 inhibits apoptosis and attenuates inflammation in nucleus pulposus cells

陆军军医大学学报, 2023
Objective To explore the effect and mechanism of zinc finger protein A20 in the nucleus pulposus cells of intervertebral disc with hypoxic conditions.
GUO Shuaichi, LIU Hao, HAN Zhenghan, LIU Wenjun, LIU Bo   +4 more
doaj   +1 more source

Study on the effeets of hypoxia on the level of OCN in nucleus pulposus cells

上海师范大学学报. 自然科学版, 2015
In order to studing the effects of hypoxia on the level of OCN in nucleus pulposus cells.Human nucleus pulposus cell were line cultured in vitro.The growth morphological of nucleus pulposus cells were observed under a microscope.Two groups of cells were ...
WU Yuanmin, XU Yuanjun, WANG Shanjin, TAN Jun   +3 more
doaj   +1 more source

Increased hemoglobin and heme in MALDI-TOF MS analysis induce ferroptosis and promote degeneration of herniated human nucleus pulposus

Molecular Medicine, 2021
Background Neovasculogenesis is characteristic of herniated lumbar discs, in which extruded nucleus pulposus is prone to heme iron-induced cytotoxicity (increased oxidative stress causing ferroptosis).
Liang Shan, Ximing Xu, Jing Zhang, Peng Cai, Han Gao, Yingjie Lu, Jiangang Shi, Yinlong Guo, Yue Su   +8 more
doaj   +1 more source

Gene expression profiling in nucleus pulposus of human ruptured lumbar disc herniation

Frontiers in Pharmacology, 2022
Purpose: To examine the differences in gene expression between ruptured and non-ruptured nucleus pulposus tissues of the intervertebral discs using gene chip technology.Methods: A total of 8 patients with nucleus pulposus from a lumbar disc herniation ...
Xiaochun Li, Xiaochun Li, Xueqiang Shen, Xueqiang Shen, Zhiqiang Wang, Zhiqiang Wang, Hong Jiang, Hong Jiang, Zhijia Ma, Zhijia Ma, Pengfei Yu, Pengfei Yu, Zhenhan Yu, Zhenhan Yu, Xiang Qian, Xiang Qian, Jintao Liu, Jintao Liu   +17 more
doaj   +1 more source

Nucleus pulposus cell-matrix interactions with laminins

European Cells and Materials, 2011
The cells of the nucleus pulposus (NP) region of the intervertebral disc play a critical role in this tissue's generation and maintenance, and alterations in NP cell viability, metabolism, and phenotype with aging may be key contributors to progressive disc degeneration.
CL Gilchrist, AT Francisco, GE Plopper, J Chen, LA Setton   +4 more
openaire   +3 more sources

LncRNA NEAT1 promotes nucleus pulposus cell matrix degradation through regulating Nrf2/ARE axis

European Journal of Medical Research, 2021
Background This study aimed to assess the role and mechanism of lncRNA NEAT1 in intervertebral disc degeneration (IVD). Methods LncRNA profile (GSE56081) between IVD and healthy control was downloaded from the Gene Expression Omnibus (GEO) database and ...
Cheng Li, Xinjian Ma, Chenfei Ni, Jingyan Xu, Yinfei Xie, Junwei Kan, Xiaoli Wei   +6 more
doaj   +1 more source

Expression files of healthy human nucleus pulposus and annulus fibrosus data

, 2022
Five human nucleus pulposus were subjected to 10x Genomics platform for scRNA-seq, related to GSE160756. Expression data were recorded as UMI matrix, of which rownames are genes and colnames are cells (nucleus pulposus), or cellranger output matrics ...
Jian He (12326264)
core   +1 more source

Effect of hydrogel stiffness on nucleus pulposus cell phenotypes in vitro and its repairment of intervertebral disc in vivo

Shanghai Jiaotong Daxue xuebao. Yixue ban, 2023
Objective·To investigate the effect of hydrogel stiffness on nucleus pulposus cell phenotype and its function in repairing intervertebral disc degeneration in rats.Methods·Methacrylate gelatin (GelMA) hydrogels with different concentrations were ...
CHEN Zehao, LÜ Zhendong, ZHANG Zhen, CUI Wenguo, ZHANG Yuhui   +4 more
doaj   +1 more source

Expansion of FGFR3-positive nucleus pulposus cells plays important roles in postnatal nucleus pulposus growth and regeneration

Stem Cell Research & Therapy, 2022
AbstractBackgroundIntervertebral disc degeneration (IVDD) can cause low back pain, a major public health concern. IVDD is characterized with loss of cells especially those in nucleus pulposus (NP), due to the limited proliferative potential and regenerative ability.
Meng Xu, Junlan Huang, Min Jin, Wanling Jiang, Fengtao Luo, Qiaoyan Tan, Ruobin Zhang, Xiaoqing Luo, Liang Kuang, Dali Zhang, Sen Liang, Huabing Qi, Hangang Chen, Zhenhong Ni, Nan Su, Jing Yang, Xiaolan Du, Bo Chen, Chuxia Deng, Yangli Xie, Lin Chen   +20 more
openaire   +3 more sources