Results 11 to 20 of about 4,980,963 (235)

MiR-27a regulates apoptosis in nucleus pulposus cells by targeting PI3K. [PDF]

PLoS ONE, 2013
The precise role of apoptosis in the pathogenesis of intervertebral disc degeneration (IDD) remains to be elucidated. We analyzed degenerative nucleus pulposus (NP) cells and found that the expression of miR-27a was increased.
Gang Liu, Peng Cao, Huajiang Chen, Wen Yuan, Jianxi Wang, Xianye Tang   +5 more
doaj   +2 more sources

Cell sources for nucleus pulposus regeneration

European Spine Journal, 2016
Purpose: There is increasing interest in the development of cell therapy as a possible approach for the treatment of degenerative disc disease. To regenerate nucleus pulposus tissue, the cells must produce an appropriate proteoglycan-rich matrix, as this
Kregar Velikonja, N, Urban, J, Fröhlich, M, Neidlinger-Wilke, C, Kletsas, D, Potocar, U, Turner, S, Roberts, S   +7 more
core   +4 more sources

Scutellarin reduces apoptosis of nucleus pulposus cells in intervertebral disc degeneration of rat models [PDF]

Jichu yixue yu linchuang
Objective To investigate the effects of scutellarin (SCU) on apoptosis of nucleus pulposus cells and the Janus kinas 2/signal transducer and activator of transcription 3 (JAK2/STAT3) signaling pathway in intervertebral disc degeneration (IVDD) model rats.
LI Na, ZHANG Peng, ZHANG Nan, LIN Wei, LIU Defeng, ZHENG Jihui
doaj   +2 more sources

Directed Differentiation of Notochord-like and Nucleus Pulposus-like Cells Using Human Pluripotent Stem Cells

Cell Reports, 2020
Summary: Intervertebral disc degeneration might be amenable to stem cell therapy, but the required cells are scarce. Here, we report the development of a protocol for directed in vitro differentiation of human pluripotent stem cells (hPSCs) into ...
Yuelin Zhang, Zhao Zhang, Peikai Chen, Chui Yan Ma, Cheng Li, Tiffany Y.K. Au, Vivian Tam, Yan Peng, Ron Wu, Kenneth Man Chee Cheung, Pak C. Sham, Hung-fat Tse, Danny Chan, Victor Y. Leung, Kathryn S.E. Cheah, Qizhou Lian   +15 more
doaj   +3 more sources

IL-1β increases asporin expression via the NF-κB p65 pathway in nucleus pulposus cells during intervertebral disc degeneration

Scientific Reports, 2017
Disc degeneration (DD) is a multifaceted chronic process that alters the structure and function of intervertebral discs. The pathophysiology of degeneration is not completely understood, but the consensus is that changes in genes encoding extracellular ...
Shengjie Wang, Chao Liu, Zhongyi Sun, Peng Yan, He Liang, Kai Huang, Changwei Li, Jiwei Tian   +7 more
doaj   +2 more sources

Versatile Microgel Platform for Intervertebral Disc Degeneration Therapy: Targeting Pericyte-Mediated Fibrosis and Protecting Nucleus Pulposus Cells. [PDF]

Adv Sci (Weinh)
The engineered MMS@TRP microgel enables targeted, acid‐responsive delivery of a miR‐21 inhibitor to pericytes. It effectively suppresses disc fibrosis by inhibiting TGF‐β signaling while protecting nucleus pulposus cells via sustained, antioxidant tannic acid release.
Ma F, Zhao Z, Guo C, Liu Y, Wang Y, Yao D, Lan W, Zhong D, Fan C, He Y, Zhang M, Kong Q, Lin Y.   +12 more
europepmc   +2 more sources

Cell sources proposed for nucleus pulposus regeneration [PDF]

JOR SPINE, 2021
AbstractLower back pain (LBP) occurs in 80% of adults in their lifetime; resulting in LBP being one of the biggest causes of disability worldwide. Chronic LBP has been linked to the degeneration of the intervertebral disc (IVD). The current treatments for chronic back pain only provide alleviation of symptoms through pain relief, tissue removal, or ...
Williams, Rebecca J., Tryfonidou, Marianna A., Snuggs, Joseph Wiliam, Le Maitre, Christine Lyn   +3 more
openaire   +7 more sources

Alterations of bovine nucleus pulposus cells with aging

Aging Cell, 2023
AbstractAging is one of the major etiological factors driving intervertebral disc (IVD) degeneration, the main cause of low back pain. The nucleus pulposus (NP) includes a heterogeneous cell population, which is still poorly characterized. Here, we aimed to uncover main alterations in NP cells with aging. For that, bovine coccygeal discs from young (12 
Maria Molinos, Morena F. Fiordalisi, Joana Caldeira, Catarina R. Almeida, Mário A. Barbosa, Raquel M. Gonçalves   +5 more
openaire   +3 more sources

The Poisson’s ratio of the nucleus pulposus is strain dependent [PDF]

, 2012
Part of the Soft Tissue Biomechanics Session this presentation is to characterise the true Poisson’s ratio of the nucleus pulposus is strain ...
Farrell, Mark, Riches, Philip
core   +4 more sources

Vitamin D inhibits TNF-α induced apoptosis of human nucleus pulposus cells through regulation of NF-kB signaling pathway

Journal of Orthopaedic Surgery and Research, 2021
Background To observe the effects of vitamin D on the apoptotic human nucleus pulposus cells under tumor necrosis factor-α (TNF-α) treatment. Methods The gene expression data was downloaded from the NCBI Gene Expression Omnibus (GEO) database ( https ...
Cun Zhang, Tong Tong, De-chao Miao, Lin-feng Wang   +3 more
doaj   +1 more source