Results 21 to 30 of about 12,120 (223)

Nucleus Pulposus Cell Conditioned Medium Promotes Mesenchymal Stem Cell Differentiation into Nucleus Pulposus-Like Cells under Hypoxic Conditions [PDF]

Stem Cells International, 2020
Low back pain (LBP) is a major physical and socioeconomic challenge worldwide. Nucleus pulposus (NP) is directly associated with LBP due to intervertebral disc (IVD) degeneration. IVD degeneration is mainly caused by structural and matrix-related changes within the IVD occurring during aging and degeneration.
Arjun Sinkemani, Feng Wang, Zhiyang Xie, Lu Chen, Cong Zhang, Xiaotao Wu   +5 more
openaire   +3 more sources

The responses of nucleus pulposus cells to pressure and ultrasound stimulation [PDF]

The Journal of the Acoustical Society of America, 2020
A cellular stimulation device with a pressurized chamber is developed to investigate the effect of ultrasound and pressure fluctuation on nucleus pulposus (NP) cells. The pressurized chamber is designed to emulate the in vivo environment of intervertebral discs, which are under dynamic pressure, and to emulate impact during sports and exercise.
Ya-Cherng Chu, Jormay Lim, Mu-Cyun Tseng, Jaw-Lin Wang   +3 more
openaire   +2 more sources

Supplementary Material for: Lentivirus-shRNA mediated prolyl hydroxylase 2 knockdown increases HIF-1α and inhibits nucleus pulposus cells degeneration

, 2021
Hypoxia-inducible factor (HIF) plays a crucial role in regulating the hypoxia-inducible state of nucleus pulposus cells in the intervertebral disc. In addition, the oxygen-dependent conversion of HIF-1α in nucleus pulposus cells is controlled by the ...
Shi F. (11705888), Mao G. (11705891), Yang X. (3341028), Yang C. (4140691), Zhou C. (3333507), Chen Q. (3335055), Liu L. (2945928), Song Y. (3137490)   +7 more
core   +2 more sources

The Regenerative Potential of Notochordal Cells in a Nucleus Pulposus Explant [PDF]

Global Spine Journal, 2017
Study Design In vitro disk explant culture. Objective Notochordal cells (NCs) have been shown to upregulate matrix production by nucleus pulposus (NP) cells in coculture.
Arkesteijn, Irene, Potier, Esther, Ito, Keita   +2 more
openaire   +2 more sources

Towards Tissue-Specific Stem Cell Therapy for the Intervertebral Disc: PPARδ Agonist Increases the Yield of Human Nucleus Pulposus Progenitor Cells in Expansion [PDF]

, 2021
(1) Background: Low back pain (LBP) is often associated with intervertebral disc degeneration (IVDD). Autochthonous progenitor cells isolated from the center, i.e., the nucleus pulposus, of the IVD (so-called nucleus pulposus progenitor cells (NPPCs ...
Guerrero, Julien, Croft, Andreas, Gantenbein, Benjamin, Albers, Christoph E., Andreas Croft, Albers, Christoph, Zhang, Xingshuo, Häckel, Sonja, Christoph Albers, Oswald, Katharina, Benjamin Gantenbein, Croft, Andreas S., Xingshuo Zhang, Katharina Oswald, Sonja Häckel, Julien Guerrero, Oswald, Katharina A.C.   +16 more
core   +1 more source

Increased hemoglobin and heme in MALDI-TOF MS analysis induce ferroptosis and promote degeneration of herniated human nucleus pulposus

Molecular Medicine, 2021
Background Neovasculogenesis is characteristic of herniated lumbar discs, in which extruded nucleus pulposus is prone to heme iron-induced cytotoxicity (increased oxidative stress causing ferroptosis).
Liang Shan, Ximing Xu, Jing Zhang, Peng Cai, Han Gao, Yingjie Lu, Jiangang Shi, Yinlong Guo, Yue Su   +8 more
doaj   +1 more source

Gene expression profiling in nucleus pulposus of human ruptured lumbar disc herniation

Frontiers in Pharmacology, 2022
Purpose: To examine the differences in gene expression between ruptured and non-ruptured nucleus pulposus tissues of the intervertebral discs using gene chip technology.Methods: A total of 8 patients with nucleus pulposus from a lumbar disc herniation ...
Xiaochun Li, Xiaochun Li, Xueqiang Shen, Xueqiang Shen, Zhiqiang Wang, Zhiqiang Wang, Hong Jiang, Hong Jiang, Zhijia Ma, Zhijia Ma, Pengfei Yu, Pengfei Yu, Zhenhan Yu, Zhenhan Yu, Xiang Qian, Xiang Qian, Jintao Liu, Jintao Liu   +17 more
doaj   +1 more source

LncRNA NEAT1 promotes nucleus pulposus cell matrix degradation through regulating Nrf2/ARE axis

European Journal of Medical Research, 2021
Background This study aimed to assess the role and mechanism of lncRNA NEAT1 in intervertebral disc degeneration (IVD). Methods LncRNA profile (GSE56081) between IVD and healthy control was downloaded from the Gene Expression Omnibus (GEO) database and ...
Cheng Li, Xinjian Ma, Chenfei Ni, Jingyan Xu, Yinfei Xie, Junwei Kan, Xiaoli Wei   +6 more
doaj   +1 more source

Effect of hydrogel stiffness on nucleus pulposus cell phenotypes in vitro and its repairment of intervertebral disc in vivo

Shanghai Jiaotong Daxue xuebao. Yixue ban, 2023
Objective·To investigate the effect of hydrogel stiffness on nucleus pulposus cell phenotype and its function in repairing intervertebral disc degeneration in rats.Methods·Methacrylate gelatin (GelMA) hydrogels with different concentrations were ...
CHEN Zehao, LÜ Zhendong, ZHANG Zhen, CUI Wenguo, ZHANG Yuhui   +4 more
doaj   +1 more source

Angiopoietin-1 receptor Tie2 distinguishes multipotent differentiation capability in bovine coccygeal nucleus pulposus cells. [PDF]

, 2016
BACKGROUND The intervertebral disc (IVD) has limited self-healing potential and disc repair strategies require an appropriate cell source such as progenitor cells that could regenerate the damaged cells and tissues.
Daisuke Sakai, Benjamin Gantenbein, Grad, Sibylle, Adel Tekari, Gantenbein, Benjamin, Sakai, Daisuke, Samantha C. W. Chan, Tekari, Adel, Sibylle Grad, Chan, Samantha C.W.   +9 more
core   +1 more source