Results 121 to 130 of about 12,120 (223)

Polyethylene microplastics promote nucleus pulposus cell senescence by inducing oxidative stress via TLR4/NOX2 axis

Ecotoxicology and Environmental Safety
This study aimed to detect and characterize microplastics in intervertebral disc and investigate their effects and molecular mechanism on intervertebral disc degeneration.
Weilin Zhang, Zhencong Li, Zhongwei Wang, Kuize Liu, Shengbang Huang, Jinguo Liang, Zhiwen Dai, Weixiong Guo, Chao Mao, Siyuan Chen, Jinsong Wei   +10 more
doaj   +1 more source

Biomimetic Hydrogels for In Vitro Modelling of Nucleus Pulposus Degeneration: Effects of Extracellular Matrix Compositional Change on Physicochemical Properties and Cell Phenotype

Journal of Functional Biomaterials
The intervertebral disc, an anatomical compartment interposed between vertebral bodies, plays a key role in spine flexibility and compression loading.
Narjes Rashidi, Nicholas Dowell, Derek Covill, John Shepperd, Matteo Santin   +4 more
doaj   +1 more source

Investigation of the HIF-PHD System in Nucleus Pulposus Cells of the Intervertebral Disc

, 2016
Low back pain is a taxing condition, both on the individual and on society. Although low back pain has several etiologies, intervertebral disc degeneration is considered a likely cause of a large percentage of cases.
Schoepflin, Zachary
core  

Role of tumor necrosis factor-alpha, interleukin-8, and dexamethasone in the focal adhesion kinase expression by human nucleus pulposus cells.

, 2007
STUDY DESIGN: Human nucleus pulposus cells from intervertebral disc specimens were cultured to study the effects of tumor necrosis factor (TNF)-alpha and interleukin (IL)-8 on the focal adhesion kinase (FAK) expression by these cells.
이운규
core   +1 more source

BIOCHEMICAL AND BIOMECHANICAL SUBSTANTIATION OF REPARATIVE REGENERATION OF INTERVERTEBRAL DISCS IN PATIENTS WITH DEGENERATIVE DISC DISEASES

Східноукраїнський медичний журнал, 2020
Degenerative disc diseases occupy the second place in the overall structure of morbidity with temporary disability. In 40% of patients with spinal osteochondrosis, diseases of the locomotor apparatus and connective tissue cause primary disability.
J. A. Bodnarchuk, M. V. Khyzhnjak, О. О. Potapov, N. G. Chopik   +3 more
doaj  

The Onset of Systemic Lupus Erythematosus Triggers Nucleus Pulposus Cell Pyroptosis to Exacerbate Intervertebral Disc Degeneration

Zhaobai Lao,1,* Xuliang Fang,1,* Shuchao Shen,1,* Yuliang Zhang,2,* Xin Chen,1 Helou Zhang,1 Yishan Bian,1 Chengcong Zhou,1 Ronghua Bao,2 Taotao Xu,3 Hongting Jin,1 Fangda Fu,1 Chengliang Wu,1 Changfeng Hu,4 Hongfeng Ruan1 1Institute of ...
Zhang H, Lao Z, Wu C, Bao R, Fang X, Hu C, Jin H, Ruan H, Fu F, Zhang Y, Zhou C, Bian Y, Xu T, Shen S, Chen X   +14 more
core  

GP014: Effect of different Cryopreservation Media on Human Nucleus Pulposus Cells' Viability and Trilineage Potential

, 2021
Introduction: Low back pain (LBP) is a significant cause of disability in many countries, affecting more than half a billion people worldwide. In the past, progenitor cells have been found within the nucleus pulposus (NP) of the human intervertebral disc
Guerrero, Julien, Oswald, Katharina A. C., Croft, Andreas S., Gantenbein, B., Albers, Christoph E., Häckel, Sonja   +5 more
core  

Characterization of the Nucleus Pulposus Progenitor Cells via Spatial Transcriptomics

Advanced Science
AbstractLoss of refreshment in nucleus pulposus (NP) cellularity leads to intervertebral disc (IVD) degeneration. Nevertheless, the cellular sequence of NP cell differentiation remains unclear, although an increasing body of literature has identified markers of NP progenitor cells (NPPCs).
Yu Chen, Long Zhang, Xueqing Shi, Jie Han, Jingyu Chen, Xinya Zhang, Danlin Xie, Zan Li, Xing Niu, Lijie Chen, Chaoyong Yang, Xiujie Sun, Taifeng Zhou, Peiqiang Su, Na Li, Matthew B. Greenblatt, Rongqin Ke, Jianming Huang, Zhe‐Sheng Chen, Ren Xu   +19 more
openaire   +3 more sources

Hybrid PVA-xanthan gum hydrogels as nucleus pulposus substitutes

, 2019
Hybrid hydrogels were synthesized mixing poly(vinyl alcohol) (PVA) and xanthan gum (XG) in different molar ratios and using trisodium trimetaphosphate, as crosslinking agent, to obtain potential nucleus pulposus substitutes.
Leone, Gemma, Bonechi, Claudia, Consumi, Marco, Lamponi, Stefania, Donati, Alessandro, Magnani, Agnese, Rossi, Claudio, Tamasi, Gabriella   +7 more
core   +1 more source

Palmitic acid induces lipid droplet accumulation and senescence in nucleus pulposus cells via ER-stress pathway

Communications Biology
Intervertebral disc degeneration (IDD) is a highly prevalent musculoskeletal disorder affecting millions of adults worldwide, but a poor understanding of its pathogenesis has limited the effectiveness of therapy.
Xi Chen, Kun Chen, Jun Hu, Yijun Dong, Menglong Zheng, Jiang Jiang, Qingsong Hu, Wenzhi Zhang   +7 more
doaj   +1 more source