Results 121 to 130 of about 4,980,963 (235)

Dorsal ischaemic myelopathy in a dog: A case of unilateral, focal predominantly sensory loss

Veterinary Record Case Reports, Volume 14, Issue 4, November 2026.
Abstract A 3‐year‐3‐month‐old, neutered, male Great Dane was presented with peracute left hindlimb monoparesis. Although voluntary movement was present, the dog was effectively non‐ambulatory due to its size. Proprioception, nociception and spinal reflexes were absent in the left hindlimb, localising the lesion to a left L4–S1 myelopathy.
Alexandra Ayoub, Ana Maria Oliveira, Nicholas Goody, Aran Nagendran   +3 more
wiley   +1 more source

Minimal Sustainability of Dedifferentiation by ROCK Inhibitor on Rat Nucleus Pulposus Cells In Vitro

Spine Surgery and Related Research, 2019
Introduction: Intervertebral disc degeneration is strongly associated with low back pain. Cell transplantation has been extensively studied as a treatment option for intervertebral disc degeneration. It is often necessary to perform cell culture prior to
Tadashi Nukaga, Daisuke Sakai, Jordy Schol, Kaori Suyama, Tomoko Nakai, Akihiko Hiyama, Masahiko Watanabe   +6 more
doaj   +1 more source

Optical Detection of Cellular Signals at Material Interfaces

Advanced Healthcare Materials, Volume 15, Issue 37, 9 October 2026.
Emerging functional materials are transforming optical detection of cellular signals. This review highlights optical techniques that exploit the unique optical properties of diverse materials to detect and quantify cellular electrical, chemical, and mechanical signals, and discusses key opportunities and challenges.
Xuchen Ren, Jitong Ren, Zixin Zhang, Koney Eungkon Kim, Francis L. Hong, Yuecheng Peter Zhou   +5 more
wiley   +1 more source

Mitochondria‐Targeted Nanotherapeutics: A Promising Strategy in Modulating Mitochondrial Function, Transfer, and Transplantation

Advanced Science, Volume 13, Issue 58, 19 October 2026.
This review summarizes the pathogenic role of mitochondria in diseases and highlights mitochondrial transfer and transplantation as emerging therapeutic strategies. It systematically discusses how nanomaterials are engineered to facilitate these processes, and critically examines the current challenges and future perspectives for their clinical ...
Yuanyuan Su, Zhiyan Gong, Jiao Mu, Lili Huang, Pengfei Yang, Chenli Zhang, Lingshan Zhao, Liling Yang, Jun Deng, Xiaohui Liao   +9 more
wiley   +1 more source

Successful fishing for nucleus pulposus progenitor cells of the intervertebral disc across species [PDF]

, 2018
Background context: Recently, Tie2/TEK receptor tyrosine kinase (Tie2 or syn. Ang-1 angiopoetin-1 receptor) positive nucleus pulposus progenitor cells were detected in human, cattle and mouse.
Nakamura, Yoshihiko, Daniela A. Frauchiger, Rahel D. May, Gantenbein, Benjamin, Sakai, Daisuke, Grad, S., May, Rahel D, Creemers, L. B., Tryfonidou, Marianna A., Tomoko Nakai, Benjamin Gantenbein, Creemers, Laura B.; id_orcid, Bach, F. C., Laura B. Creemers, Bach, Frances C., Sakai, D., Frances C. Bach, Sagawa, Nobuho, Nakai, T., Nobuho Sagawa, Sagawa, N., Frauchiger, Daniela A, Watanabe, Masahiko, Sibylle Grad, Masahiko Watanabe, Chan, Samantha C.W., Orthopedie en neurochirurgie, Marianna A. Tryfonidou, May, Rahel D., Tryfonidou, Marianna A, Jordy Schol, Bach, Frances C, Tekari, A., Creemers, Laura B, Yoshihiko Nakamura, Schol, J., Tryfonidou, M. A., Daisuke Sakai, Frauchiger, Daniela A., Nakamura, Y., dCSCA RMSC-1, Samantha C.W. Chan, Chan, Samantha C W, Schol, Jordy, Tekari, Adel, Nakai, Tomoko, Grad, Sibylle, Adel Tekari, Chan, Samantha, Frauchiger, Daniela Angelika, May, Rahel Deborah, Tryfonidou MA, Creemers LB, Watanabe M, May RD, Sakai D, Nakamura Y, Schol J, Grad S, Chan SCW, Frauchiger DA, Gantenbein B, Sagawa N, Bach FC, Tekari A, Nakai T   +65 more
core   +2 more sources

Identification and Experimental Validation of PANoptosis Key Genes for Constructing a PANoptosis Risk Diagnostic Model in Intervertebral Disc Degeneration

The Journal of Gene Medicine, Volume 28, Issue 10, October 2026.
This study identified seven PANoptosis key genes (ACSBG1, FXYD1, APCS, CEACAM1, ERAP2, ABL1, and FZD3) in intervertebral disc degeneration (IDD) through integrated bioinformatics analysis of GEO datasets. Using machine learning algorithms (RF, SVM, XGB, and GLM), a PANoptosis risk diagnostic model was constructed and validated.
Kui Deng, Xia Lan, WenZhao Chen, LiuXue Du, JiangWei Chen   +4 more
wiley   +1 more source

Co-culturing nucleus pulposus mesenchymal stem cells with notochordal cell-rich nucleus pulposus explants attenuates tumor necrosis factor-α-induced senescence

Stem Cell Research & Therapy, 2018
Background Cell therapy for the treatment of intervertebral disc degeneration (IDD) faces serious barriers since tissue-specific adult cells such as nucleus pulposus cells (NPCs) have limited proliferative ability and poor regenerative potential; in ...
Xiao-Chuan Li, Mao-Sheng Wang, Wei Liu, Cheng-Fan Zhong, Gui-Bin Deng, Shao-Jian Luo, Chun-Ming Huang   +6 more
doaj   +1 more source

Hippo Pathway–YAP/TAZ Signaling: Molecular Mechanisms, Biological Function, Diseases, and Therapeutic Targets

MedComm, Volume 7, Issue 10, October 2026.
The Hippo–YAP/TAZ–TEAD pathway integrates mechanical and biochemical cues to govern organ growth, regeneration, cancer, and fibrosis. This review dissects pathway physiology, TEAD structural pharmacology and ligandable pockets, and therapeutic strategies spanning palmitoylation‐pocket inhibitors, PROTAC degraders, and gene/RNA therapies, highlighting ...
Xiaodan Qu, Zhan‐you Wang
wiley   +1 more source

Small Proteoglycans, Big Impact: Decorin, Biglycan, and Asporin in Musculoskeletal Tissue Health and Disease

Proteoglycan Research, Volume 4, Issue 4, October 2026.
ABSTRACT The extracellular matrix (ECM) is a dynamic and information‐rich network that integrates structural support with biochemical and mechanical signaling. Among its key regulatory components are the Small Leucine‐Rich Proteoglycans (SLRPs), a family of matrix molecules that coordinate extracellular architecture with cell signaling.
Alessandra Leone, Zsuzsa Jenei‐Lanzl, Frank Zaucke   +2 more
wiley   +1 more source

SIRT6 Activation Improves Intervertebral Disc Health in the Aging Spine

Aging Cell, Volume 25, Issue 10, October 2026.
Our studies for the first time underscore the feasibility of long‐term SIRT6 activation as a pharmacological strategy to maintain the health of the intervertebral disc in the aging spine. ABSTRACT Aging is a critical risk factor for intervertebral disc degeneration, a major contributor to chronic low back pain.
Pranay Ramteke, Bahiyah Watson, Sanjana Jagannath, Sarah E. Bell, Mallory Toci, Olivia Ottone, Qinglin Wu, Oliver Abinader, Ramkrishna Mitra, John A. Collins, Ruteja A. Barve, Makarand V. Risbud   +11 more
wiley   +1 more source