Results 191 to 200 of about 12,120 (223)
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Acta Biomaterialia, 2018
Stem cell-based tissue engineering is a promising treatment for intervertebral disc (IVD) degeneration. A bio-scaffold that can maintain the function of transplanted cells and possesses favorable mechanical properties is needed in tissue engineering. Decellularized nucleus pulposus (dNP) has the potential to be a suitable bio-scaffold because it mimics
Xiaopeng Zhou +2 more
exaly +3 more sources
Stem cell-based tissue engineering is a promising treatment for intervertebral disc (IVD) degeneration. A bio-scaffold that can maintain the function of transplanted cells and possesses favorable mechanical properties is needed in tissue engineering. Decellularized nucleus pulposus (dNP) has the potential to be a suitable bio-scaffold because it mimics
Xiaopeng Zhou +2 more
exaly +3 more sources
Indian Journal of Cancer, 2015
To investigate the feasibility of inducing adipose-derived stem cells (ADSCs) to nucleus pulposus cells (NPCs).ADSCs were isolated from rabbit while NPCs were isolated from an allogeneic rabbit. NPCs were co-cultured with the 3rd generation ADSCs in co-cultured system. Only NPCs were cultured in single culturing group.
J, Xu, D L, Qi, X J, Pang, C W, Jing
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To investigate the feasibility of inducing adipose-derived stem cells (ADSCs) to nucleus pulposus cells (NPCs).ADSCs were isolated from rabbit while NPCs were isolated from an allogeneic rabbit. NPCs were co-cultured with the 3rd generation ADSCs in co-cultured system. Only NPCs were cultured in single culturing group.
J, Xu, D L, Qi, X J, Pang, C W, Jing
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Influence of intradiscal medication on nucleus pulposus cells
The Spine Journal, 2013Eugene Carragee was the first to prove that provocative discography may contribute to intervertebral disc degeneration. Disc degeneration can be induced either by mechanical trauma caused by the puncturing needle or as a pharmacological effect of the drugs instilled into the disc.The aim of this study was to test the influence of cortisone, lidocaine ...
Claudia, Eder +5 more
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Expression of cytokeratin and vimentin in nucleus pulposus cells
Differentiation, 1988With immunohistochemistry using monoclonal antibodies against intermediate filament proteins, nucleus pulposus cells were found to express cytokeratin(s) simultaneously with vimentin in fetal life and childhood. This finding adds to the series of human tissues showing coexpression of cytokeratins and vimentin.
P, Stosiek, M, Kasper, U, Karsten
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Nucleus pulposus degeneration alters properties of resident progenitor cells [PDF]
Spine Journal, 2013 The intervertebral disc (IVD) possesses a minimal capability for self-repair and regeneration. Changes in the differentiation of resident progenitor cells can represent diminished tissue regeneration and a loss of homeostasis. We previously showed that progenitor cells reside in the nucleus pulposus (NP). The effect of the degenerative process on these
Dmitriy Sheyn +2 more
exaly +3 more sources
Spine, 2014
Human stromal stem cells derived from menstrual blood (MenSCs) and nucleus pulposus (NP) cells were cocultured under normal or low oxygen (O2) condition.To assess the differentiation capability of MenSCs toward nucleus pulposus cells under normal or low oxygen condition.Given the proliferative capacity and pluripotentiality of mesenchymal stem cells ...
Xuqi, Hu +12 more
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Human stromal stem cells derived from menstrual blood (MenSCs) and nucleus pulposus (NP) cells were cocultured under normal or low oxygen (O2) condition.To assess the differentiation capability of MenSCs toward nucleus pulposus cells under normal or low oxygen condition.Given the proliferative capacity and pluripotentiality of mesenchymal stem cells ...
Xuqi, Hu +12 more
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A novel and efficient method for culturing mouse nucleus pulposus cells
Spine Journal, 2019As degeneration of the nucleus pulposus (NP) is a major cause of intervertebral disc degeneration, research directed toward nucleus pulposus cells (NPCs) is drawing increased attention. However, caused by the difficulties associated with their harvest and culture, there are few reports describing cultivation methods for mouse NP cells (mNPCs).To ...
Junichi Kushioka +2 more
exaly +3 more sources
Differentiation of mesenchymal stem cells into nucleus pulposus cells in vitro
Journal of Huazhong University of Science and Technology [Medical Sciences], 2008To find a new source of seed cells for constructing tissue-engineered intervertebral disc, nucleus pulposus (NP) cells and mesenchymal stem cells (MSCs) were isolated from New Zealand white rabbits. The nucleus pulposus cells population was fluorescence-laelled and co-cultured with MSCs with or without direct contact.
Fenghua, Tao +3 more
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Notochordal Cells Interact with Nucleus Pulposus Cells: Regulation of Proteoglycan Synthesis
Experimental Cell Research, 1999The disappearance of notochordal cells is correlated with early degenerative changes in the intervertebral disc. With increased disc degeneration there is a marked decrease in proteoglycan synthesis, resulting in loss of mechanical function. One possible mechanism for the decrease in proteoglycan synthesis is the loss of notochordal cells from the ...
Theodore R Oegema
exaly +3 more sources
An injectable vehicle for nucleus pulposus cell-based therapy
Biomaterials, 2011An injectable hydrogel, acting as a reservoir for cell delivery and mimicking the native environment, offers promise for nucleus pulposus (NP) repair and regeneration. Herein, the potential of a stabilised type II collagen hydrogel using poly(ethylene glycol) ether tetrasuccinimidyl glutarate (4S-StarPEG) cross-linker, enriched with hyaluronic acid (HA)
Estelle C, Collin +8 more
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