Results 201 to 210 of about 12,120 (223)
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Tissue Engineering Part A, 2017
Recent studies suggested that notochordal cells (NCs) and NC-conditioned medium (NCCM) can stimulate cell viability and matrix production of nucleus pulposus cells (NPCs). However, the potential of notochordal cell-rich nucleus pulposus (NRNP) incorporating the native environment of the intervertebral disc (IVD) has not been evaluated. The objective of
Xue-Dong, Bai +7 more
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Recent studies suggested that notochordal cells (NCs) and NC-conditioned medium (NCCM) can stimulate cell viability and matrix production of nucleus pulposus cells (NPCs). However, the potential of notochordal cell-rich nucleus pulposus (NRNP) incorporating the native environment of the intervertebral disc (IVD) has not been evaluated. The objective of
Xue-Dong, Bai +7 more
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Tissue Engineering Part A, 2012
The aim of this study was to evaluate whether human Wharton's jelly cells (WJCs) could be differentiated into nucleus pulposus (NP)-like cells by coculturing with NP cells (NPCs) in vitro. WJCs were isolated from the human umbilical cord, and NPCs were isolated from healthy human intervertebral disc.
Dike, Ruan +10 more
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The aim of this study was to evaluate whether human Wharton's jelly cells (WJCs) could be differentiated into nucleus pulposus (NP)-like cells by coculturing with NP cells (NPCs) in vitro. WJCs were isolated from the human umbilical cord, and NPCs were isolated from healthy human intervertebral disc.
Dike, Ruan +10 more
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Cell Biology International, 2013
AbstractNucleus pulposus mesenchymal stem cells (NPMSCs) are a potential cell source for intervertebral disc (IVD) regeneration, but little is known about their response to IVD‐like high osmolarity (400 mOsm). This study was to investigate the viability, proliferation and protein biosynthesis of nucleus pulposus cells (NPCs), NPMSCs and co‐cultured ...
Yi-Qing, Tao +6 more
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AbstractNucleus pulposus mesenchymal stem cells (NPMSCs) are a potential cell source for intervertebral disc (IVD) regeneration, but little is known about their response to IVD‐like high osmolarity (400 mOsm). This study was to investigate the viability, proliferation and protein biosynthesis of nucleus pulposus cells (NPCs), NPMSCs and co‐cultured ...
Yi-Qing, Tao +6 more
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Differentiation of adipose stem cells by nucleus pulposus cells: Configuration effect
Biochemical and Biophysical Research Communications, 2007Degenerative disc disease (DDD) is a major cause of chronic low back pain. For mild/intermediate DDD, regeneration by injecting adipose stem cells (ASCs) into the nucleus pulposus (NP) may be considered. The goal of this study is to investigate whether NP cells can direct ASCs towards the NP phenotype.
Lu, Z. +4 more
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Mechanobiology of annulus fibrosus and nucleus pulposus cells in intervertebral discs
Cell and Tissue Research, 2019Low back pain (LBP) is a chronic condition that can affect up to 80% of the global population. It is the number one cause of disability worldwide and has enormous socioeconomic consequences. One of the main causes of this condition is intervertebral disc (IVD) degeneration.
Sara Molladavoodi +2 more
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Malignant Granular Cell Tumor Mimicking Herniated Nucleus Pulposus
Clinical Orthopaedics and Related Research, 1996Peripheral nerve tumors may arise in any nerve, large or small. Their presence is readily apparent when they are superficial, but when they are located in a deep nerve, symptoms can mimic+ the nerve root pain of herniated nucleus pulposus. This case of malignant granular cell tumor, probably of Schwann cell origin, involved the sciatic and tibial ...
A L, Saperstein +4 more
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Ultrastructure of the human intervertebral disc: II. Cells of the nucleus pulposus
The Anatomical Record, 1982AbstractThe cells of the intervertebral disc exist in a unique environment; not only are discs subject to large mechanical loads, they are the largest avascular structures in the body. To describe the ultrastructure and age changes in cells from human nucleus pulposus, we studied these cells in individuals ranging in age from the 26th week of fetal ...
J J, Trout, J A, Buckwalter, K C, Moore
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Active cell proliferation contributes to the enlargement of the nascent nucleus pulposus
Developmental DynamicsAbstractBackgroundThe notochord is an embryonic organ involved in forming and patterning the spinal column. The mechanism by which the notochord transforms from a continuous rod to a segmented structure excluded from the vertebrae and residing solely as the nucleus pulposus within the intervertebral disc is understudied.
Rose G. Long +2 more
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