Results 51 to 60 of about 259,805 (253)

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Mechanisms of parasite‐mediated disruption of brain vessels

FEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira, Sílvia Arroz‐Madeira, Cláudio A. Franco, Sara Silva Pereira   +3 more
wiley   +1 more source

Responses of Semi-Scavenging F1 Crossbred (Rhode Island Red Male ×Fayoumi Female) Grower and Pre-Layer Chickens to Diets of Different Nutrient Density Formulated with Locally Available Feed Ingredients

The Journal of Poultry Science, 2007
Two experiments were conducted to investigate the birds’ responses to diets of varying nutrient concentrations, one with 126 eight-week old F1 crossbred (Rhode Island Red male×Fayoumi female) birds up to 20 weeks of age (growing stage) and ...
Manotosh Dhar, Sachchidananda D. Chowdhury, Md. A. Ali, Md. J. Khan, Md. A.H. Pramanik   +4 more
doaj   +1 more source

Energy density, nutrient density and nutrient-to-price ratio of Indonesian foods

Food Research
Understanding the concepts of energy density (ED), nutrient density (ND), and nutrient-to -price ratio (NPR) in foods is crucial in making food selections to overcome the triple burden of malnutrition in Indonesia. This study aimed to examine the ED, ND and NPR values of Indonesian foods. A cross-sectional study was conducted to collect mostly consumed
W. Rahmawati, N.N. Wirawan, I. Fahmi, A.R. Cempaka, S. Andarini   +4 more
openaire   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Interactive effects of dietary energy levels with amino acid density on growth performance and optimal digestible Lys to energy ratio of male broiler chickens

Poultry Science
: A total of 2,400 day-old off-sex male Ross 308 chicks were used in a 4 × 3 factorial array (8 replicates with 25 birds per replicate) to determine the interactive effects of dietary metabolizable energy (ME) and amino acid (AA) densities on productive ...
Mehdi Toghyani, Shemil MacElline, Peter H. Selle, Sonia Y. Liu   +3 more
doaj   +1 more source