Results 121 to 130 of about 89,427 (290)

TOPK Inhibition Promotes Anti‐Tumor Immunity Via eIF4F Complex Mediated STAT1 Translation in Gastric Cancer

Advanced Science, EarlyView.
This study identifies TOPK as a dual‐function target in gastric cancer: it drives tumor cell proliferation and migration, and under IFN‐γ stimulation, phosphorylates eIF4F complex component eIF4A1 to enhance STAT1 mRNA translation, thereby promoting PD‐L1/IDO1‐mediated tumor immunometabolic evasion.
Junbing Chen, Longtao Huangfu, Gangjian Wang, Xueying Wang, Huanbo Zhu, Qian Yao, Cong Chen, Xiaohuan Tang, Ting Guo, Biao Fan, Xingyang Liu, Qingda Li, Zining Liu, Ying Hu, Tianze Sun, Jiafu Ji, Xiaofang Xing   +16 more
wiley   +1 more source

AN ANALYSIS OF PRODUCERS' OPINIONS ON MANDATORY LABELING OF GM PRODUCTS [PDF]

This study evaluates producers' perceptions on mandatory labeling of GM food products. The analysis is based on a sample of 1,887 farmers in 10 southern states who claimed to be "somewhat knowledgeable" about biotechnology.
Chaverest, E'licia L., Chembezi, Duncan M., Kebede, Ellene, Wheelock, Gerald   +3 more
core   +1 more source

The Gut Commensal Butyricimonas Virosa Modulates Gut Microbiota‐Dependent Thiamine Metabolism and Attenuates Mouse Steatotic Liver Disease

Advanced Science, EarlyView.
This study reveals that dietary stachyose enriches Butyricimonas virosa, effectively attenuating metabolic dysfunction‐associated steatotic liver disease (MASLD). Mechanistically, B. virosa enhances gut thiamine monophosphate synthesis, which elevates hepatic thiamine pyrophosphate levels.
Ningning He, Haoyu Wang, Zizhen Yang, Hui Li, Bei Liu, Kaiwei Chen, Zhinan Wu, Xinnan Zhao, Hewei Liang, Mengmeng Wang, Xiaofang Li, Yiyi Zhong, Haifeng Zhang, Liang Xiao, Karsten Kristiansen, Jixing Peng, Yuanqiang Zou, Shangyong Li   +17 more
wiley   +1 more source

Multidimensional evaluation of nutritional security policies in the Republic of Moldova: gaps, progress, and alignment with international standards

Frontiers in Public Health
IntroductionNutritional security is increasingly recognized as a critical component of public health, particularly in addressing the growing burden of non-communicable diseases such as obesity, diabetes, and cardiovascular disease.
Rodica Siminiuc, Dinu Țurcanu, Sergiu Siminiuc   +2 more
doaj   +1 more source

Multi‐View Biomedical Foundation Models for Molecule‐Target and Property Prediction

Advanced Science, EarlyView.
Molecular foundation models can provide accurate predictions for a large set of downstream tasks. We develop MMELON, an approach that integrates pre‐trained graph, image, and text foundation models and validate our multi‐view model on over 120 tasks, including GPCR binding.
Parthasarathy Suryanarayanan, Yunguang Qiu, Shreyans Sethi, Diwakar Mahajan, Hongyang Li, Yuxin Yang, Elif Eyigoz, Aldo Guzmán‐Sáenz, Daniel E. Platt, Timothy H. Rumbell, Kenney Ng, Sanjoy Dey, Myson Burch, Bum Chul Kwon, Pablo Meyer, Feixiong Cheng, Jianying Hu, Joseph A. Morrone   +17 more
wiley   +1 more source

Barriers and facilitators to the implementation of a qualitative menu labeling in a self-service buffet restaurant: operators and employees perspectives

Demetra
Introduction: Eating out is associated with consuming lower-nutritional-quality foods. Restaurants can provide menu labeling for culinary preparations to assist consumers in their food choices.
Natalia Fogolari, Rossana Pacheco da Costa Proença, Camila Lunardi Mondadori Messaggi, Pauline Bitzer Rodrigues, Aline Nalon Zaghi, Renata Carvalho de Oliveira, Greyce Luci Bernardo, Paula Lazzarin Uggioni, Ana Carolina Fernandes   +8 more
doaj   +1 more source

CACLENS: A Multitask Deep Learning System for Enzyme Discovery

Advanced Science, EarlyView.
CACLENS, a multimodal and multi‐task deep learning framework integrating cross‐attention, contrastive learning, and customized gate control, enables reaction type classification, EC number prediction, and reaction feasibility assessment. CACLENS accelerates functional enzyme discovery and identifies efficient Zearalenone (ZEN)‐degrading enzymes.
Xilong Yi, Yingzhu Tan, Huikang Lin, Guoqing Zhang, Ye Tian, Aibo Wu   +5 more
wiley   +1 more source

INTEGRATION OF A PRODUCT CHOICE MODEL AND A LATENT VARIABLE MODEL OF NUTRITION INFORMATION [PDF]

We develop and estimate an integrated discrete choice model system of product choice and nutrition information for prepared frozen meals in the United States in the period from 1993 to 1998, when government regulation of nutrition labeling changed from ...
Mojduszka, Eliza M.
core   +1 more source

How Supermarkets Are Shaping Up and Growing Their Lower-Calorie Products [PDF]

, 2015
The Centers for Disease Control and Prevention (CDC) estimates that more than a third of adults and nearly 17 percent of children in the United States are obese.
Hank Cardello, Jeffrey Wolfson
core  

Synthetic Lethal Therapy Based on Dimorphism for Systemic Infection of Drug‐Resistant Candida albicans

Advanced Science, EarlyView.
To tackle the alarming mortality rate linked to Candida albicans infections, a synthetic lethal strategy precisely aimed at the two distinct forms of this fungus: yeast and hyphae is formulated. Ultimately, through the innovative use of macrophage membranes for drug delivery, the effectiveness of this strategy is substantially boosted while ...
Yang Gao, Jiahe Su, Jiawei Yuan, Qinyan Cao, Yue Wu, Yuyang Xiao, Guang Yang, Ruomu Xia, Jingpeng Yang, Yanan Li, Lina Wu, He Huang, Lingtong Meng   +12 more
wiley   +1 more source