Results 101 to 110 of about 14,068 (233)

Translating cardiovascular ion channel and Ca2+ signalling mechanisms into therapeutic insights

The Journal of Physiology, EarlyView.
Abstract figure legend This white paper integrates mechanistic discoveries across ion channel biology, Ca2+ signalling and multiscale cardiovascular physiology to highlight new opportunities for accelerating research and guiding next‐generation therapies. Printed with permission from ®Anita Impagliazzo Medical Illustration. [Correction added on 2 March
Silvia Marchianò, Miguel Martín‐Aragón Baudel, Charlotte E. R. Smith, Gonzalo Hernandez Hernandez, Donald M. Bers, Patrick M. Boyle, Dobromir Dobrev, Shanna Hamilton, Osama F. Harraz, Na Li, Thomas A. Longden, William E. Louch, Madeline Nieves‐Cintron, Matthew A. Nystoriak, Walter Lee Murfee, Przemysław B. Radwański, Swapnil K. Sonkusare, Manuel F. Navedo, Eleonora Grandi   +18 more
wiley   +1 more source

Deciphering the functions of O-GlcNAc glycosylation in the brain: The role of site-specific quantitative O-GlcNAcomics [PDF]

, 2018
The dynamic posttranslational modification O-linked β-N-acetylglucosamine glycosylation (O-GlcNAcylation) is present on thousands of intracellular proteins in the brain.
Hsieh-Wilson, Linda C., Sorum, Alexander W., Thompson, John W.   +2 more
core  

Effects of hypo O-GlcNAcylation on Drosophila development [PDF]

, 2018
Post-translational modification of serine/threonine residues in nucleocytoplasmic proteins with N-acetylglucosamine (OGlcNAcylation) is an essential regulatory mechanism in many cellular processes.
Andrew T. Ferenbach, Baena-Lopez, Barrangou, Bassett, Bassett, Biryukova, Bond, Bouazzi, Brennan, Buse, Capotosti, Capotosti, Chou, Chu, Culí, Daan M.F. van Aalten, Daniel Mariappa, Doudna, Douris, Dura, Erickson, Furrer, Gambetta, Gambetta, Gantz, García-Bellido, Gratz, Gratz, Guinez, Hart, Hart, Hartenstein, Hu, Huang, Hwang, Ingham, Jang, Jinek, Julien, Kazemi, Kenwrick, Kristie, Lim, Lin, Liu, Mao, Mariappa, Mariappa, Müller, Niranjan, O'Donnell, Olivier-Van Stichelen, Parker, Pfaffl, Prescott, Radermacher, Rodriguez-Jato, Romani, Ruan, Selvan, Shafi, Sheldon, Sinclair, Sohn, Swamy, Treisman, Tyagi, Vella, Wang, Webster, Yi, Yin, Yu, Zachara, Zachara, Zhu, Zimmer   +76 more
core   +3 more sources

Fatty Acid Metabolism in Health and Cancer: From Fundamental Mechanisms to Therapeutic Application

MedComm, Volume 7, Issue 6, June 2026.
The modulation of the TME by fatty acid metabolism primarily occurs through four key pathways: inflammation regulation, signal transduction, translation to TME, and oxidative stress. ABSTRACT Fatty acid metabolism (FAM) plays a vital role in maintaining health by supporting energy production, cellular structure, and signaling processes.
Na Hang, Runkang Zhao, Fan Zhang, Dandan Guo, Qing Li, Zhijun Shen, Ruiqing Gao, Chenyu Gao, Zhao Xie, Sentao Fu, Peng Luo, Bufu Tang, Ling Wang   +12 more
wiley   +1 more source

O-GlcNAcylation of core components of the translation initiation machinery regulates protein synthesis [PDF]

, 2019
Protein synthesis is essential for cell growth, proliferation, and survival. Protein synthesis is a tightly regulated process that involves multiple mechanisms.
Cheng, Yaxian, Chu, Jennifer, Duan, Xiaotao, Hsieh-Wilson, Linda C., Li, Sihui, Li, Xueliu, Li, Xuexia, Ni, Maowei, Pelletier, Jerry, Shi, Xiaoliu, Xu, Huan, Yi, Wen, Zheng, Zhiguo, Zhu, Qiang   +13 more
core  

Metabolic control of hyaluronan synthases [PDF]

, 2014
Hyaluronan (HA) is a glycosaminoglycan composed by repeating units of D-glucuronic acid (GlcUA) and N-acetylglucosamine (GlcNAc) that is ubiquitously present in the extracellular matrix (ECM) where it has a critical role in the physiology and pathology ...
De Luca G., Karousou E., Passi A., Vigetti D., Viola M.   +4 more
core   +1 more source

The Dual Role of Autophagy in Cancer: Mechanisms and Therapeutic Strategies

MedComm – Oncology, Volume 5, Issue 2, June 2026.
Autophagy is a conserved cellular process degrading dysfunctional organelles and protein aggregates to maintain cell homeostasis, and it exhibits context‐dependent duality in cancer. Autophagy functions as a critical tumor‐suppressive mechanism by preventing DNA damage and mutation during tumor initiation.
Xiang‐Zheng Gao, Yuheng Qin, Haoyu Wan, Guang Lu, Han‐Ming Shen   +4 more
wiley   +1 more source

The glycosyltransferase EOGT regulates adropin expression in decidualizing human endometrium [PDF]

, 2017
In pregnancy, resistance of endometrial decidual cells to stress signals is critical for the integrity of the feto-maternal interface and, by extension, survival of the conceptus. O-GlcNAcylation is an essential post-translational modification that links
Alam, Mohammad T., Aplin, John D., Barros, Flavio S. V., Brosens, Jan J., Ewington, Lauren J., Muter, Joanne, Ruane, Peter T., Vrljicak, Pavle, Westwood, Melissa   +8 more
core   +2 more sources

Engineered Microfluidic Organoid Systems: New Paradigms for Menopause Mechanism Research and Personalized Medicine

Advanced Materials Technologies, Volume 11, Issue 9, 6 May 2026.
This review explores the integration of microfluidic technology with organoid systems as an innovative platform for studying menopausea complex multi‐organ condition. By enabling precise simulation of inter‐organ communication and hormone responses, microfluidic organoids offer a physiologically relevant model for investigating menopausal syndrome and ...
Qianyi Zhang, He Huang, Hongliang Dong, Qiang Ma, Hongyan Jin   +4 more
wiley   +1 more source

O-GlcNAc of STING mediates antiviral innate immunity

Cell Communication and Signaling
Background O-GlcNAcylation modification affects multiple physiological and pathophysiolocal functions of cells. Altered O-GlcNAcylation was reported to participate in antivirus response.
Yujia Li, Wang An, Liyuan Lu, Jiali Yuan, Danhui Wu, Qi Yang, Jinrong Guo, Jingyu Yang, Mengjie Liu, Kaiyue He, Xinyuan Lei, Zhi-Xiang Xu   +11 more
doaj   +1 more source