Results 111 to 120 of about 14,068 (233)
Frontiers in Endocrinology, 2018 The formation of intraneuronal fibrillar inclusions of tau protein is associated with several neurodegenerative diseases referred to as tauopathies including Alzheimer's disease (AD).
Gwendoline Bourré +5 more
doaj +1 more source
Mitochondrial Dynamics at the Interface of Immune Cell Metabolism and Function
, 2018 Immune cell differentiation and function are crucially dependent on specific metabolic programs dictated by mitochondria, including the generation of ATP from the oxidation of nutrients and supplying precursors for the synthesis of macromolecules and ...
Pearce, E., Rambold, A.
core +1 more source
Optimization of chemoenzymatic mass-tagging by strain-promoted cycloaddition (SPAAC) for the determination of O-GlcNAc stoichiometry by Western blotting [PDF]
, 2018 The dynamic modification of intracellular proteins by O-linked β-N-acetylglucosamine (O-GlcNAcylation) plays critical roles in many cellular processes.
Chuh, Kelly N. +4 more
core +3 more sources
T Cell O‐GlcNAcylation Increases in Patients With Allergic Rhinitis After the Natural Pollen Season
Clinical &Experimental Allergy, EarlyView.
Eduardo I. Cardenas +7 more
wiley +1 more source
Glucose metabolic reprogramming as a driver of immunosuppression in the tumour microenvironment
Clinical and Translational Medicine, Volume 16, Issue 5, May 2026.Glucose metabolic reprogramming is a central driver of immunosuppression in the tumour microenvironment, orchestrating immune dysfunction through multiple interconnected mechanisms. Glucose competition establishes a selective bioenergetic hierarchy that constrains antitumour immunity, whereas lactate accumulation and its reciprocal crosstalk with ...
Yang Wang +3 more
wiley +1 more source
O-GlcNAcylation levels remain stable regardless of the anaesthesia in healthy rats
Scientific ReportsAnaesthetics are used daily in human and veterinary medicine as well as in scientific research. Anaesthetics have an impact on cell homeostasis especially through modulation of protein post-translational modifications.
Thomas Dupas +16 more
doaj +1 more source
The dynamic metabolism of hyaluronan regulates the cytosolic concentration of UDP-GlcNAc [PDF]
, 2014 Hyaluronan, a macromolecular glycosaminoglycan, is normally synthesized by hyaluronan synthases at the plasma membrane using cytosolic UDP-GlcUA and UDP-GlcNAc substrates and extruding the elongating chain into the extracellular space.
Hanson, R.W. +8 more
core +1 more source
Diabetes/Metabolism Research and Reviews, Volume 42, Issue 4, May 2026.Central illustration: Pathophysiological mechanisms linking diabetes mellitus and cardiovascular disease. Chronic hyperglycaemia, insulin resistance, and low‐grade inflammation contribute to endothelial dysfunction, myocardial fibrosis, and cardiomyocyte apoptosis.
Lilian Anagnostopoulou +13 more
wiley +1 more source
Comprehensive mapping of O-GlcNAc modification sites using a chemically cleavable tag [PDF]
, 2016 The post-translational modification of serine or threonine residues of proteins with a single N-acetylglucosamine monosaccharide (O-GlcNAcylation) is essential for cell survival and function.
Griffin, Matthew E. +6 more
core +3 more sources
Journal of Cellular Physiology, Volume 241, Issue 5, May 2026.ABSTRACT Cancer cells rewire their metabolism to sustain a high proliferation rate. Sensing external cues is essential to match the metabolic fluxes of the cells to the external stimuli. As part of the glucose metabolism, the hexosamine biosynthesis pathway (HBP) is considered a nutrient‐sensing pathway. The HBP produces UDP‐GlcNAc, a key precursor for
Pegah Rahimizadeh +4 more
wiley +1 more source