Results 121 to 130 of about 14,068 (233)

Liver Stiffness Characterization of OGTLKO Mouse Model of Progressive Liver Fibrosis

Journal of Ultrasound in Medicine, Volume 45, Issue 5, Page 1069-1082, May 2026.
Objectives O‐GlcNAcylation plays a key regulatory role in hepatic physiology, and its disruption leads to fibrosis in liver‐specific OGT knockout mice (OGTLKO), making this model valuable for studying advanced metabolic dysfunction‐associated steatohepatitis (MASH).
Gilles Renault, Lenin Chinchilla, Lourdes Massengo, Pierre Monbernard, Fadila Benhamed, Marion Regnier, Raphael Denis, Catherine Postic, Anthony Novell, Jean‐Luc Gennisson   +9 more
wiley   +1 more source

Thio-linked UDP-peptide conjugates as O-GlcNAc transferase inhibitors [PDF]

, 2018
O-GlcNAc transferase (OGT) is an essential glycosyltransferase that installs the O-GlcNAc post-translational modification on the nucleocytoplasmic proteome. We report the development of S-linked UDP–peptide conjugates as potent bisubstrate OGT inhibitors.
Andrii Gorelik, Bogachev V. S., Daan M. F. van Aalten, Derossi D., Dong D. L., Karim Rafie, Riccardo Trapannone, Torres C. R., Vladimir S. Borodkin   +8 more
core   +3 more sources

Interplay of RNA m6A/m1A/m5C/m7G/ψ Regulators Predicting the Prognosis of Pancreatic Cancer

FASEB BioAdvances, Volume 8, Issue 5, May 2026.
In this study, we comprehensively analyze the 64 RNA modification regulators, including 24 m6A regulators, 13 m1A regulators, 12 m5C regulators, 9 m7G regulators, and 12 pseudouridine regulators in pancreatic cancer in TCGA, GTEx, and HPA databases. We investigate their RNA and protein expression, their association with patients' clinical significance,
Shiyin Chen, Jiawei Mao, Lin Xu, Linbei Lu, Yajuan Hao   +4 more
wiley   +1 more source

High fat diet attenuates the anticontractile activity of aortic PVAT via a mechanism involving AMPK and reduced adiponectin secretion [PDF]

, 2018
Background and aim: Perivascular adipose tissue (PVAT) positively regulates vascular function through production of factors such as adiponectin but this effect is attenuated in obesity.
Alganga, Husam, Almabrouk, Tarek A.M., Guzik, Tomasz J., Katwan, Omar J., Kennedy, Simon, Salt, Ian P., Skiba, Dominik S., Touyz, Rhian M., Ugusman, Azizah B., White, Anna D.   +9 more
core   +2 more sources

Mitochondrial Homeostasis in Pancreatic β Cell Function: Mechanisms and Therapeutic Targets for Diabetes

Journal of Diabetes, Volume 18, Issue 5, May 2026.
This review highlights mitochondrial dysfunction as a central driver of pancreatic β cell failure in diabetes, caused by disrupted mitochondrial quality control (MQC), oxidative stress, and impaired organelle communication. Emerging therapies, such as DRAK2 inhibitors and metabolic reprogramming agents, show promise in restoring β cell function by ...
Ruihan Li, Bingqian Zhang, Yuxin Zhang, Yang Yang, Yuting Lu, Jingya Li   +5 more
wiley   +1 more source

Hcfc1 and Ogt Mediate Zebrafish CNS Regeneration Through Hippo/Yap Signalling

Cell Proliferation, Volume 59, Issue 5, May 2026.
This work identifies Hcfc1 and Ogt as key regulators of zebrafish CNS regeneration through modulation of Hippo/Yap signalling. Loss of Hcfc1 or Ogt activity inhibition impairs regeneration, which is restored by Yap overexpression, revealing a new regulatory axis that enhances CNS regenerative capacity.
Priyanka P. Srivastava, Sidharth Bhasin, Poonam Sharma, Omkar Mahadeo Desai, Kshitiz Yadav, Ayushma, Rohan Chakraborty, Suhel Parvez, Rajesh Ramachandran, Shilpi Minocha   +9 more
wiley   +1 more source

Suppressed OGT expression inhibits cell proliferation while inducing cell apoptosis in bladder cancer

BMC Cancer, 2018
Background This study aimed to explore hyper-O-linked N-acetylglucosaminylation (O-GlcNAcylation) with an elevation of the expression of O-linked-β-N-acetylglucosamine transferase (OGT) in human bladder cancer.
Longsheng Wang, Shaojun Chen, Ziwei Zhang, Junfeng Zhang, Shiyu Mao, Jiayi Zheng, Yang Xuan, Mengnan Liu, Keke Cai, Wentao Zhang, Yadong Guo, Wei Zhai, Xudong Yao   +12 more
doaj   +1 more source

Liver X receptor regulates hepatic nuclear O-GlcNAc signaling and carbohydrate responsive element-binding protein activity [PDF]

, 2015
Liver X receptor (LXR)α and LXRβ play key roles in hepatic de novo lipogenesis through their regulation of lipogenic genes, including sterol regulatory element-binding protein (SREBP)-1c and carbohydrate responsive element-binding protein (ChREBP).
Bindesbøll, Christian, Fan, Qiong, Grønning-Wang, Line M, MacPherson, Laura, Mandrup, Susanne, Matthews, Jason, Nebb, Hilde I, Nørgaard, Rikke C, Pedersen, Thomas Å, Ruan, Hai-Bin, Steffensen, Knut R, Wu, Jing, Yang, Xiaoyong   +12 more
core   +2 more sources

Nutrient sensing, signal transduction and immune responses [PDF]

, 2016
Most cells in the body have a constant supply of nutrients, which are required to sustain cellular metabolism and functions. In contrast, cells of the immune system can encounter conditions with a limited nutrient supply during the course of an immune ...
Alvarez-Curto, Alvarez-Curto, Ananieva, Ananieva, Andersen, Arpaia, Atarashi, Bah, Balmer, Bar-Peled, Bauman, Benhamed, Bensinger, Bertolotti, Bharadwaj, Blagih, Bond, Briscoe, Brown, Brown, Carr, Chang, Chang, Chang, Chantranupong, Chen, Chou, Cobbold, Cui, Cummins, David Finlay, Delgoffe, Delgoffe, Diczfalusy, Donnelly, Donohoe, Fallarino, Feng, Fossati, Furusawa, Garcia-Navas, Glozak, Gold, Golks, Gonzalez, Grallert, Grebe, Hannedouche, Harig, Hart, Hart, Hayashi, Heine, Hirayama, Ho, Hockel, Hong, Horton, Hou, Hu, Huang, Ichimura, Im, Jabara, Jessica Walls, Kanai, Keil, Kidani, Kim, Kneass, Kneass, Le Poul, Linda Sinclair, Liu, Liu, Liu, Maciejewski-Lenoir, Macintyre, MacIver, Maianski, Mangalam, Maslowski, Mayer, Mukhopadhyay, Munger, Munn, Murakami, Nakaya, Nath, Nicklin, Noman, O'Neill, Oh, Orsini, Pallett, Piccoli, Pollizzi, Powell, Preston, Radhakrishnan, Ramakrishnan, Ravindran, Ravindran, Rawson, Rebsamen, Ripoli, Rodriguez, Rodriguez-Espinosa, Rolf, Rose, Ryu, Santori, Schaub, Scheppach, Sheedy, Sinclair, Singh, Smith, Soroosh, Spann, Steffensen, Su, Suzuki, Swamy, Talukdar, Tamune, Tang, Tarhda, Taylor, Thai, Thangaraju, Tremaroli, Urasaki, van Baren, Verbist, Vinolo, Vitko, Wang, Wang, Wang, Wang, Wang, Weichhart, Wolfson, Xing, Xu, Yan, Yang, Yang, York, York, Yu, Zeng, Zhong   +153 more
core   +2 more sources

O-Glcnacylation Is Essential for Erythropoiesis

Blood, 2019
Understanding the molecular mechanisms of erythropoiesis is critical for treating anemia and other hematopoietic diseases, which affect roughly 3 million Americans and 28% of the global population. The role of post-translational modification (PTM) of proteins in regulating developmental and differentiation processes is understudied, but recently we ...
Matthew P Parker, Halyna Fedosyuk, Lesya V Novikova, Zhen Zhang, Chad Slawson, Kenneth R Peterson   +5 more
openaire   +1 more source