Results 131 to 140 of about 14,068 (233)

Influence of O-GlcNAcylation on KGN cell function

Endocrine and Metabolic Science
O-GlcNAcylation is a unique form of post-translational glycosylation that affects a variety of cytoplasmic and nuclear proteins of cells. Aberrant O-GlcNAcylation is characteristic of many cancers, and impacts cell proliferation, tumorigenicity and ...
Abigail M. Maucieri, David H. Townson
doaj   +1 more source

O-GlcNAcase Fragment Discovery with Fluorescence Polarimetry [PDF]

, 2018
The attachment of the sugar N-acetyl-D-glucosamine (GlcNAc) to specific serine and threonine residues on proteins is referred to as protein O-GlcNAcylation.
Aristotelous, Tonia, Borodkin, Vladimir S., Ferenbach, Andrew T., Navratilova, Iva, Rafie, Karim, Selvan, Nithya, Van Aalten, Daan M.F.   +6 more
core   +3 more sources

The effects of O-GlcNAc alteration on Alzheimer-like neurodegeneration in SK-N-SH cells

Biomedical Papers, 2018
Background: O-GlcNAcylation is a highly dynamic post-translational modification that plays a key role in regulating phosphorylation of protein and cell survival.
Nan Ding, Peng Peng, Yu-Jing Chu, Jing-Jing Wang, Shu-Yi Chen, Renuka Arulthas, Yan-Qiu Deng   +6 more
doaj   +1 more source

O‐GlcNAcylation of the Human Kinome

The FASEB Journal, 2018
O‐GlcNAc, first characterized more than 30 years ago, is an O‐linked β‐N‐acetylglucosamine moiety attached to the side chain hydroxyl of a serine or threonine residue. O‐GlcNAc has been found on over 4,000 cytoplasmic and nuclear proteins. The addition of O‐GlcNAc to proteins is catalyzed by O‐GlcNAc transferase (OGT) while its removal is catalyzed by ...
Xin Liu, Guanghui Han, Santosh Renuse, Akhilesh Pandey, Heng Zhu, Gerald Hart   +5 more
openaire   +1 more source

O-GlcNAcylation in ovarian tumorigenesis and its therapeutic implications

Translational Oncology
Ovarian cancer is a prevalent malignancy among women, often associated with a poor prognosis. Post-translational modifications (PTMs), particularly O-GlcNAcylation, have been implicated in the progression of ovarian cancer.
Lu Xia, Jie Mei, Min Huang, Dandan Bao, Zhiwei Wang, Yizhe Chen   +5 more
doaj   +1 more source

Suppressed OGT expression inhibits cell proliferation and modulates EGFR expression in renal cell carcinoma

Cancer Management and Research, 2019
Longsheng Wang,1 Shaojun Chen,2 Junfeng Zhang,1 Shiyu Mao,1 Weipu Mao,1 Wentao Zhang,1 Yadong Guo,1 Yuan Wu,1 Ruiliang Wang,1 Yang Yan,1 Xudong Yao1 1Department of Urology, Shanghai Tenth People’s Hospital, Tongji University, School of Medicine ...
Wang L, Chen S, Zhang J, Mao S, Mao W, Zhang W, Guo Y, Wu Y, Wang R, Yan Y, Yao X   +10 more
doaj  

O-GlcNAcylation of NONO regulates paraspeckle component assembly and contributes to colon cancer cell proliferation

Cell Death Discovery
Non-POU domain-containing octamer-binding protein (NONO) is a multifunctional member of the Drosophila behavior/human splicing (DBHS) protein family with DNA- and RNA-binding activity.
Yeolhoe Kim, Kyung-Tae Lee, Han Byeol Kim, Hyeryeon Jung, Jeong Yeon Ko, Tae Hyun Kweon, Hari Chandana Yadavalli, Junghwa Seo, Suena Ji, Yun Ju Kim, Donghyuk Shin, Seong Wook Yang, Myeong Min Lee, Jin Won Cho, Eugene C. Yi, Jin-Wu Nam, Won Ho Yang   +16 more
doaj   +1 more source

Human Pulmonary Artery Endothelial Cells Increased Glycolysis and Decreased Nitric Oxide Synthase O-GlcNAcylation in Pulmonary Arterial Hypertension

International Journal of Translational Medicine
Pulmonary arterial hypertension (PAH) is a fatal disease that primarily affects women. In PAH, endothelial cells become dysfunctional, reducing production of the vasodilator nitric oxide while increasing proliferation.
Sarah E. Basehore, Alisa Morss Clyne
doaj   +1 more source

O-GlcNAcylation of METTL3 drives hepatocellular carcinoma progression by upregulating MCM10 expression in an m6A-IGF2BP3-dependent manner

Cell Death and Disease
The m6A methyltransferase METTL3 is a key regulator of RNA m6A modification, which plays a critical role in cancer development. Despite the significance of METTL3 in hepatocellular carcinoma (HCC), its post-translational modifications and their ...
Zhen Chen, Jiaxin Yin, Zhongqi Feng, Yanlai Zhang, Li Liang, Xiaojun Wang, Kai Wang, Ni Tang   +7 more
doaj   +1 more source

O‐GlcNAcylation of Kinases

The FASEB Journal, 2007
Wagner Barbosa Dias, Gerald W Hart
openaire   +1 more source