Results 171 to 180 of about 4,120 (207)

Benzylpenicillin inhibits the renal excretion of acyclovir by OAT1 and OAT3

Pharmacological Reports, 2013
Acyclovir is acyclic guanosine derivative. Benzylpenicillin (PCG) is a β-lactam antibiotic. The purpose of this study was to investigate the pharmacokinetic drug-drug interaction (DDI) between PCG and acyclovir.When acyclovir and PCG were co-administered, plasma concentration of acyclovir, urinary excretion of acyclovir in vivo, uptake of acyclovir in ...
Jianghao, Ye, Qi, Liu, Changyuan, Wang, Qiang, Meng, Huijun, Sun, Jinyong, Peng, Xiaochi, Ma, Kexin, Liu   +7 more
openaire   +2 more sources

Expression and Function of Oat1 and Oat3 in Rat Kidney Exposed to Mercuric Chloride

Archives of Toxicology, 2009
This study was designed to evaluate the expression and function of the organic anion transporters, Oat1 and Oat3, in rats exposed to a nephrotoxic dose of HgCl(2). Oat1 protein expression increased in renal homogenates and decreased in renal basolateral membranes from HgCl(2) rats, while Oat3 protein abundance decreased in both kidney homogenates and ...
Gisela Di Giusto, Adriana Mónica Torres, Naohiko Anzai   +2 more
exaly   +3 more sources

Chlorothiazide is a Substrate for the Human Uptake Transporters OAT1 and OAT3

Journal of Pharmaceutical Sciences, 2013
The thiazide diuretic chlorothiazide is poorly metabolized, and is predominantly excreted via the kidneys. We have previously shown that chlorothiazide is transported by ATP-binding cassette transporter G2, suggesting a potential role for this transporter in apical efflux of chlorothiazide in the kidney.
Viktória, Juhász, Erzsébet, Beéry, Zoltán, Nagy, Annamária, Bui, Eva, Molnár, Joseph Krisjanis, Zolnerciks, Rémi, Magnan, Márton, Jani, Peter, Krajcsi   +8 more
openaire   +2 more sources

Developmentally Regulated Expression of Organic Ion Transporters NKT (OAT1), OCT1, NLT (OAT2), and Roct

American Journal of Physiology - Renal Physiology, 2000
Several xenobiotic (organic cation and anion) transporters have recently been identified, although their endogenous substrates, if such exist, remain unknown.
David R Beier, Alan Yu, Sanjay Nigam
exaly   +2 more sources

Organic anion transporter OAT1 is involved in renal handling of citrulline

American Journal of Physiology-Renal Physiology, 2009
Because citrulline plasma concentration is elevated in kidney failure, citrulline could be a biomarker of renal insufficiency, although the mechanism regulating its disposition in the kidney has not been clarified. In rat kidney slices, citrulline uptake was apparently Na+dependent, saturable with Km556 μM, and significantly inhibited by anionic (PAH ...
Masanori, Nakakariya, Yoichiro, Shima, Yoshiyuki, Shirasaka, Keisuke, Mitsuoka, Takeo, Nakanishi, Ikumi, Tamai   +5 more
openaire   +2 more sources

In vitro interaction of clopidogrel and its hydrolysate with OCT1, OCT2 and OAT1

International Journal of Pharmaceutics, 2014
Clopidogrel (CP) is metabolized by CYPs to the active metabolite, or hydrolyzed by esterase to clopidogrel carboxylate (CPC) in liver, and CPC is partly excreted from urine. Therefore, the objective of the present study was to evaluate the interactions of CP and CPC with organic cation transporter 1 (OCT1) (in liver), and CPC with organic cation ...
Liping, Li, Feifeng, Song, Meijuan, Tu, Kai, Wang, Lei, Zhao, Xiaodan, Wu, Hui, Zhou, Zongling, Xia, Huidi, Jiang   +8 more
openaire   +2 more sources

Functional analysis of polymorphisms in the organic anion transporter, SLC22A6 (OAT1)

Pharmacogenetics and Genomics, 2005
The organic anion transporter, OAT1 (SLC22A6), plays a role in the renal elimination of many drugs and environmental toxins. The goal of this study was to identify and functionally characterize OAT1 variants as a first step towards understanding whether genetic variation in OAT1 may contribute to interindividual differences in renal elimination of ...
Tomoe, Fujita, Chaline, Brown, Elaine J, Carlson, Travis, Taylor, Melanie, de la Cruz, Susan J, Johns, Doug, Stryke, Michiko, Kawamoto, Kazumi, Fujita, Richard, Castro, Chung-Wen, Chen, Emil T, Lin, Claire M, Brett, Esteban Gonzalez, Burchard, Thomas E, Ferrin, Conrad C, Huang, Maya K, Leabman, Kathleen M, Giacomini   +17 more
openaire   +2 more sources

Renal Expression and Function of Oat1 and Oat3 in Rats with Vascular Calcification

Pharmacology, 2012
Calcium overload in vascular smooth muscle is a highly pathogenic event, which progresses with advancing age. Old patients are polymedicated, and several pharmacotherapeutic agents circulate in the plasma as organic anions. The organic anion transporters 1 and 3 (Oat1 and Oat3) are present in renal basolateral membranes, which transport organic anions ...
Romina, Bulacio, María Herminia, Hazelhoff, Adriana Mónica, Torres   +2 more
openaire   +2 more sources

Zebrafish (Danio Rerio) Oat1 and Oat3 Transporters and Their Interaction With Physiological Compounds

Comparative Biochemistry and Physiology - B Biochemistry and Molecular Biology, 2019
Organic anion transporters (OATs) are membrane proteins within the Solute carrier family 22 (SLC22). They play important roles in cellular uptake of various organic compounds, and due to their expression in barrier tissues of major excretory and non-excretory organs are considered as crucial elements in absorption and distribution of a wide range of ...
Ivan Mihaljevic, Marta Popovic, Tvrtko Smital   +2 more
exaly   +6 more sources

Gender differences in expression of rat renal OAT1

Pflügers Archiv, 2003
The gender differences (GD) in the renal secretion of organic anions may be due to different expression levels of the organic anion transporter 1 (OAT1) in the basolateral membrane (BLM) of the S2 proximal tubule segment. By using immunofluorescence cytochemistry in cryosections of fixed renal tissue and immunoblotting of isolated renal cortical BLM ...
Burckhardt, Gerhard, Ljubojević, Marija, Herak-Kramberger, Carol M., Hagos, Yohannes, Bahn, Andrew, Endou, Hitoshi, Sabolić, Ivan   +6 more
openaire   +2 more sources