Results 171 to 180 of about 5,743 (215)

Oat1/3 restoration protects against renal damage after ischemic AKI

American Journal of Physiology-Renal Physiology, 2015
Expression of proximal tubular organic anion transporters Oat1 and Oat3 is reduced by PGE2after renal ischemia and reperfusion (I/R) injury. We hypothesized that impaired expression of Oat1/3 is decisively involved in the deterioration of renal function after I/R injury.
R, Schneider, M, Meusel, B, Betz, C, Held, K, Möller-Ehrlich, M, Büttner-Herold, C, Wanner, M, Gekle, C, Sauvant   +8 more
openaire   +2 more sources

Organic anion transporter OAT1 is involved in renal handling of citrulline

American Journal of Physiology-Renal Physiology, 2009
Because citrulline plasma concentration is elevated in kidney failure, citrulline could be a biomarker of renal insufficiency, although the mechanism regulating its disposition in the kidney has not been clarified. In rat kidney slices, citrulline uptake was apparently Na+dependent, saturable with Km556 μM, and significantly inhibited by anionic (PAH ...
Masanori, Nakakariya, Yoichiro, Shima, Yoshiyuki, Shirasaka, Keisuke, Mitsuoka, Takeo, Nakanishi, Ikumi, Tamai   +5 more
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Flavonoids Are Inhibitors of Human Organic Anion Transporter 1 (OAT1)–Mediated Transport [PDF]

Drug Metabolism and Disposition, 2014
Organic anion transporter 1 (OAT1) has been reported to be involved in the nephrotoxicity of many anionic xenobiotics. As current clinically used OAT1 inhibitors are often associated with safety issues, identifying potent OAT1 inhibitors with little toxicity is of great value in reducing OAT1-mediated drug nephrotoxicity.
Guohua An, Marilyn E Morris
exaly   +3 more sources

Functional analysis of polymorphisms in the organic anion transporter, SLC22A6 (OAT1)

Pharmacogenetics and Genomics, 2005
The organic anion transporter, OAT1 (SLC22A6), plays a role in the renal elimination of many drugs and environmental toxins. The goal of this study was to identify and functionally characterize OAT1 variants as a first step towards understanding whether genetic variation in OAT1 may contribute to interindividual differences in renal elimination of ...
Tomoe, Fujita, Chaline, Brown, Elaine J, Carlson, Travis, Taylor, Melanie, de la Cruz, Susan J, Johns, Doug, Stryke, Michiko, Kawamoto, Kazumi, Fujita, Richard, Castro, Chung-Wen, Chen, Emil T, Lin, Claire M, Brett, Esteban Gonzalez, Burchard, Thomas E, Ferrin, Conrad C, Huang, Maya K, Leabman, Kathleen M, Giacomini   +17 more
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Dihydrophenanthrenes from Juncus effusus as Inhibitors of OAT1 and OAT3

Journal of Natural Products, 2019
Organic anion transporters 1 (OAT1) and 3 (OAT3) play important roles in the renal elimination of a range of substrate molecules. Little is known about natural products that can modulate OAT1 and OAT3 activities. The medullae of Juncus effusus is often used for the treatment of dysuria in traditional Chinese medicine.
Xue Li, Yilin Qiao, Xue Wang, Ruicong Ma, Tianxiang Li, Youcai Zhang, Robert P. Borris   +6 more
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Benzylpenicillin inhibits the renal excretion of acyclovir by OAT1 and OAT3

Pharmacological Reports, 2013
Acyclovir is acyclic guanosine derivative. Benzylpenicillin (PCG) is a β-lactam antibiotic. The purpose of this study was to investigate the pharmacokinetic drug-drug interaction (DDI) between PCG and acyclovir.When acyclovir and PCG were co-administered, plasma concentration of acyclovir, urinary excretion of acyclovir in vivo, uptake of acyclovir in ...
Jianghao, Ye, Qi, Liu, Changyuan, Wang, Qiang, Meng, Huijun, Sun, Jinyong, Peng, Xiaochi, Ma, Kexin, Liu   +7 more
openaire   +2 more sources

Gender differences in expression of rat renal OAT1

Pflügers Archiv, 2003
The gender differences (GD) in the renal secretion of organic anions may be due to different expression levels of the organic anion transporter 1 (OAT1) in the basolateral membrane (BLM) of the S2 proximal tubule segment. By using immunofluorescence cytochemistry in cryosections of fixed renal tissue and immunoblotting of isolated renal cortical BLM ...
Herak-Kramberger, Carol Mirna, Ljubojević, Marija, Sabolić, Ivan   +2 more
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Chlorothiazide is a Substrate for the Human Uptake Transporters OAT1 and OAT3

Journal of Pharmaceutical Sciences, 2013
The thiazide diuretic chlorothiazide is poorly metabolized, and is predominantly excreted via the kidneys. We have previously shown that chlorothiazide is transported by ATP-binding cassette transporter G2, suggesting a potential role for this transporter in apical efflux of chlorothiazide in the kidney.
Viktória, Juhász, Erzsébet, Beéry, Zoltán, Nagy, Annamária, Bui, Eva, Molnár, Joseph Krisjanis, Zolnerciks, Rémi, Magnan, Márton, Jani, Peter, Krajcsi   +8 more
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Abstract 5471: Identification of OAT1/OAT3 as contributors to cisplatin nephrotoxicity

Cancer Research, 2015
Abstract Cisplatin is among the most widely used anticancer drugs and known to cause dose-limiting nephrotoxicity. We previously reported that renal organic cation transporters (OCT2 in humans, Oct1/Oct2 in mice) are involved in the etiology of this side effect (Filipski et al, CPT 2009), but the tubular damage is not completely ...
Shuiying Hu, Navjotsingh Pabla, Laura J. Janke, Lie Li, Aksana Vasilyeva, Jason A. Sprowl, Alex Sparreboom   +6 more
openaire   +1 more source