Results 181 to 190 of about 4,120 (207)

The Contribution of Organic Anion Transporters OAT1 and OAT3 to the Renal Uptake of Rosuvastatin

The Journal of Pharmacology and Experimental Therapeutics, 2007
No description ...
Windass A, Lowes S, Wang Y, Brown C
openaire   +3 more sources

[Tubular transporters OAT1 and MRP2 and clearance of adefovir].

Nephrologie & therapeutique, 2006
Adefovir is transported by the organic anion transporter (OAT1) and the multidrug resistant protein (MRP2, 4 and 5). We studied adefovir clearance in rat after inhibition of transporters by probenecid and in TR- rats, in which MRP2 is lacking. After treatment by probenecid or placebo, pharmacokinetics of adefovir 10 mg/kg was studied via population ...
Aude, Servais, Philippe, Lechat, Noël, Zahr, Saik, Urien, Guy, Aymard, Marie Chantal, Jaudon, Gilbert, Deray, Corinne, Isnard Bagnis   +7 more
openaire   +1 more source

Abstract 5471: Identification of OAT1/OAT3 as contributors to cisplatin nephrotoxicity

Cancer Research, 2015
Abstract Cisplatin is among the most widely used anticancer drugs and known to cause dose-limiting nephrotoxicity. We previously reported that renal organic cation transporters (OCT2 in humans, Oct1/Oct2 in mice) are involved in the etiology of this side effect (Filipski et al, CPT 2009), but the tubular damage is not completely ...
Shuiying Hu, Navjotsingh Pabla, Laura J. Janke, Lie Li, Aksana Vasilyeva, Jason A. Sprowl, Alex Sparreboom   +6 more
openaire   +1 more source

OAT1/3 regulate the absorption of CP-25 in the rat synovium

Toxicology and Applied Pharmacology
Paeoniflorin-6'-O-benzene sulfonate (CP-25) is a new ester derivative formed by esterification of paeoniflorin. We found that CP-25 inhibits the abnormal proliferation and migration of inflammatory fibroblast-like synoviocytes (FLS). However, the mechanism by which CP-25 is absorbed by FLS remains unclear.
Jinzhang, Gao, Wei, Sun, Lei, Ni, Qingqing, Sun, Jiangrui, Cheng, Ning, Xiao, Feng, Xiao, Wei, Wei, Chun, Wang   +8 more
openaire   +2 more sources

Oat1/3 restoration protects against renal damage after ischemic AKI

American Journal of Physiology-Renal Physiology, 2015
Expression of proximal tubular organic anion transporters Oat1 and Oat3 is reduced by PGE2after renal ischemia and reperfusion (I/R) injury. We hypothesized that impaired expression of Oat1/3 is decisively involved in the deterioration of renal function after I/R injury.
R, Schneider, M, Meusel, B, Betz, C, Held, K, Möller-Ehrlich, M, Büttner-Herold, C, Wanner, M, Gekle, C, Sauvant   +8 more
openaire   +2 more sources

OAT1 structures reveal insights into drug transport in the kidney

Nature Structural & Molecular Biology, 2023
openaire   +2 more sources

OAT1

2022
openaire   +1 more source

Estimation of Ontogeny Functions for Renal Transporters Using a Combined Population Pharmacokinetic and Physiology-Based Pharmacokinetic Approach: Application to OAT1,3

AAPS Journal, 2021
Elke H J Krekels, Peter De Paepe, Pieter De Cock   +2 more
exaly  

OAT1, Organic Anion Transporter 1

2007
Yohannes Hagos, Gerhard Burckhardt
openaire   +1 more source

Interaction of the Main Active Components in Shengmai Formula Mediated by Organic Anion Transporter 1 (OAT1)

Journal of Ethnopharmacology, 2022
Fanglan Liu, Chunhua Xia, Jianming Liu
exaly