Results 181 to 190 of about 5,743 (215)

Role of organic anion transporter 1 (OAT1) in cephaloridine (CER)-induced nephrotoxicity [PDF]

Kidney International, 1999
Role of organic anion transporter 1 (OAT1) in cephaloridine (CER)-induced nephrotoxicity.Cephaloridine (CER) has been used to elucidate the mechanisms of cephalosporin antibiotic-induced nephrotoxicity. Organic anion transporters have been thought to mediate CER uptake by the proximal tubule.
Takeda, Michio, Tojo, Akihiro, Sekine, Takashi, Hosoyamada, Makoto, Kanai, Yoshikatsu, Endou, Hitoshi   +5 more
exaly   +3 more sources

Some of the next articles are maybe not open access.

Related searches:

Isoflavones from Camphorosma lessingii Inhibit the Organic Anion Transporters OAT1 and OAT3

Planta Medica, 2018
AbstractPhytochemical investigation of Camphorosma lessingii has resulted in the isolation of four previously unreported isoflavones (1–4) and eight known compounds (5–12). Nine of these compounds (1–6, 8–10) are reported for the first time from members of the family Amaranthaceae.
Xinhui, Wang, Dujuan, Wang, Xue, Wang, Manana, Khutsishvili, Kamilla, Tamanyan, George, Fayvush, Daniel, Atha, Youcai, Zhang, Robert P, Borris   +8 more
openaire   +2 more sources

Caffeic acid inhibits organic anion transporters OAT1 and OAT3 in rat kidney

dmdi, 2013
Abstract Background: Some food components influence drug elimination. Previously, we found that caffeic acid, present in coffee, fruits, and vegetables, strongly inhibited human homologs of organic anion transporters (OATs) OAT1 and OAT3, which are responsible for renal tubular secretion of anionic drugs. In this study,
Yuichi, Uwai, Tatsuya, Kawasaki, Tomohiro, Nabekura   +2 more
openaire   +2 more sources

Transport of Xanthurenic Acid by Rat/Human Organic Anion Transporters OAT1 and OAT3

Bioscience, Biotechnology, and Biochemistry, 2013
Kynurenic acid, a tryptophan metabolite, is involved in psychiatric disease. Our laboratory previously described its transport by rat/human organic anion transporters rOAT1, hOAT1, rOAT3 and hOAT3, which are involved in drug disposition. In this study, we performed an uptake experiment using Xenopus laevis oocytes to examine the transport of ...
Yuichi, Uwai, Emi, Honjo
openaire   +2 more sources

Renal Expression and Function of Oat1 and Oat3 in Rats with Vascular Calcification

Pharmacology, 2012
Calcium overload in vascular smooth muscle is a highly pathogenic event, which progresses with advancing age. Old patients are polymedicated, and several pharmacotherapeutic agents circulate in the plasma as organic anions. The organic anion transporters 1 and 3 (Oat1 and Oat3) are present in renal basolateral membranes, which transport organic anions ...
Romina, Bulacio, María Herminia, Hazelhoff, Adriana Mónica, Torres   +2 more
openaire   +2 more sources

Environmental contaminants modulate transport activity of zebrafish organic anion transporters Oat1 and Oat3

Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology, 2020
Organic anion transporters (OATs) are transmembrane proteins which belong to SLC22 subfamily. They are responsible for the uptake of various endo- and xenobiotics into the cells of different organs and tissues. Following our previous work on characterization of zebrafish Oat1 and Oat3, in this study we analyzed interaction of various classes of ...
Dragojević, Jelena, Marić, Petra, Lončar, Jovica, Popović, Marta, Mihaljević, Ivan, Smital, Tvrtko   +5 more
openaire   +4 more sources

Zebrafish (Danio rerio) Oat1 and Oat3 transporters and their interaction with physiological compounds

Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology, 2019
Organic anion transporters (OATs) are membrane proteins within the Solute carrier family 22 (SLC22). They play important roles in cellular uptake of various organic compounds, and due to their expression in barrier tissues of major excretory and non-excretory organs are considered as crucial elements in absorption and distribution of a wide range of ...
Dragojević, Jelena, Mihaljević, Ivan, Popović, Marta, Smital, Tvrtko   +3 more
openaire   +5 more sources

OAT1 and OAT3 also mediate the drug-drug interaction between piperacillin and tazobactam

International Journal of Pharmaceutics, 2018
This study aimed to demonstrate that organic anion transporters (OATs) mediate the drug-drug interaction (DDI) between piperacillin and tazobactam. After co-administration with piperacillin in rats, the AUC of tazobactam in plasma was significantly increased, and t1/2β was prolonged with significant reduction in plasma clearance, renal clearance and ...
Shijie, Wen, Changyuan, Wang, Yingjie, Duan, Xiaokui, Huo, Qiang, Meng, Zhihao, Liu, Shilei, Yang, Yanna, Zhu, Huijun, Sun, Xiaodong, Ma, Siyun, Yang, Kexin, Liu   +11 more
openaire   +2 more sources

[Tubular transporters OAT1 and MRP2 and clearance of adefovir].

Nephrologie & therapeutique, 2006
Adefovir is transported by the organic anion transporter (OAT1) and the multidrug resistant protein (MRP2, 4 and 5). We studied adefovir clearance in rat after inhibition of transporters by probenecid and in TR- rats, in which MRP2 is lacking. After treatment by probenecid or placebo, pharmacokinetics of adefovir 10 mg/kg was studied via population ...
Aude, Servais, Philippe, Lechat, Noël, Zahr, Saik, Urien, Guy, Aymard, Marie Chantal, Jaudon, Gilbert, Deray, Corinne, Isnard Bagnis   +7 more
openaire   +1 more source

MDR1 and OAT1/OAT3 Mediate the Drug-Drug Interaction between Puerarin and Methotrexate

Pharmaceutical Research, 2013
To conduct in vivo and in vitro experiments to investigate puerarin (PUR), an isoflavone C-glyoside, and elucidate its ability to alter methotrexate (MTX) transport and pharmacokinetics.In vivo absorption studies, in vitro everted intestinal sac preparation, kidney slices in rats and bi-directional transport assay with mock-/MDCK-MDR1 cells, uptake ...
Qi, Liu, Changyuan, Wang, Qiang, Meng, Xiaokui, Huo, Huijun, Sun, Jinyong, Peng, Xiaochi, Ma, Pengyuan, Sun, Kexin, Liu   +8 more
openaire   +2 more sources