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OAT1/3 regulate the absorption of CP-25 in the rat synovium
Toxicology and Applied PharmacologyPaeoniflorin-6'-O-benzene sulfonate (CP-25) is a new ester derivative formed by esterification of paeoniflorin. We found that CP-25 inhibits the abnormal proliferation and migration of inflammatory fibroblast-like synoviocytes (FLS). However, the mechanism by which CP-25 is absorbed by FLS remains unclear.
Jinzhang, Gao +8 more
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Characterization of zebrafish (Danio rerio) organic anion transporters Oat1 and Oat3
2018OATS/Oats are transmembrane proteins that transport a variety of compounds including drugs, environmental toxins and endogenous metabolites into the cell. Human OAT1 and OAT3 are primarily expressed in the kidney where their physiological role is uptake of urate into the kidneys, thus representing the first step in urate excretion.
Dragojević, Jelena +2 more
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OAT1 structures reveal insights into drug transport in the kidney
Nature Structural & Molecular Biology, 2023openaire +2 more sources
Altered expression of rat renal cortical OAT1 and OAT3 in response to bilateral ureteral obstruction
Kidney International, 2005Anabel Brandoni +2 more
exaly