Quantification of atropine sulphate monohydrate and obidoxime dichloride in two‐chamber autoinjectors for accessing uniformity of dosage [PDF]
Analytical Science Advances, 2022 In the treatment of organophosphate poisoning atropine sulphate monohydrate (AT) and obidoxime dichloride (OB) play a vital role. Currently, the Austrian Armed Forces use the DOUBLEPEN OA two‐chamber autoinjector (ChemProtect) to administer these two ...
Iva Spreitzer +4 more
doaj +3 more sources
Pyridinium-2-carbaldoximes with quinolinium carboxamide moiety are simultaneous reactivators of acetylcholinesterase and butyrylcholinesterase inhibited by nerve agent surrogates [PDF]
Journal of Enzyme Inhibition and Medicinal Chemistry, 2021 The pyridinium-2-carbaldoximes with quinolinium carboxamide moiety were designed and synthesised as cholinesterase reactivators. The prepared compounds showed intermediate-to-high inhibition of both cholinesterases when compared to standard oximes. Their
Hyun Myung Lee +13 more
doaj +4 more sources
Cholinergic syndrome: a case report of acute organophosphate and carbamate poisoning [PDF]
Arhiv za Higijenu Rada i Toksikologiju, 2020 Cholinergic syndrome is a common topic at western medical universities yet rarely observed in clinical practice. The treatment involves muscarinic antagonists, acetylcholinesterase reactivation, seizure control, and supportive measures.
Petreski Tadej +4 more
doaj +4 more sources
The Experimental Oxime K027—A Promising Protector From Organophosphate Pesticide Poisoning. A Review Comparing K027, K048, Pralidoxime, and Obidoxime [PDF]
Frontiers in Neuroscience, 2019 Poisoning with organophosphorus compounds (OPCs) is a major problem worldwide. Standard therapy with atropine and established oxime-type enzyme reactivators (pralidoxime, obidoxime) is unsatisfactory.
Dietrich E. Lorke +2 more
doaj +5 more sources
A case report of severe pirimiphos-methyl intoxication: Clinical findings and cholinesterase status [PDF]
Frontiers in Pharmacology, 2022 A 63-year-old male was admitted to a district hospital after ingesting ethanol and pirimiphos-methyl (PM) with suicidal intentions. History included alcoholic cirrhosis with alcoholism, adiposity, diabetes with cerebral microangiopathy, chronic renal ...
Tobias Zellner +6 more
doaj +2 more sources
Broad-Spectrum Antidote Discovery by Untangling the Reactivation Mechanism of Nerve-Agent-Inhibited Acetylcholinesterase. [PDF]
Chemistry, 2022 Rational design of efficient antidotes to organophosphorus nerve agent (OPNA) intoxication needs to account for the complexity of the molecular system. A fragment with broad‐spectrum binding profile was transformed into a multi‐active reactivator of OPNAs‐inhibited acetylcholinesterases.
Lindgren C +9 more
europepmc +2 more sources
FDA-Approved Oximes and Their Significance in Medicinal Chemistry [PDF]
Pharmaceuticals, 2022 Despite the scientific advancements, organophosphate (OP) poisoning continues to be a major threat to humans, accounting for nearly one million poisoning cases every year leading to at least 20,000 deaths worldwide.
Jyothi Dhuguru +2 more
doaj +2 more sources
Organophosphate Poisoning: Insights From a Case Report of Acute Cholinergic Syndrome. [PDF]
Clin Case RepABSTRACT Organophosphate (OP) pesticides are widely used in agriculture and can cause acute cholinergic toxicity by inhibiting the enzyme acetylcholinesterase, leading to an accumulation of acetylcholine. A 45‐year‐old male plumber was admitted to the emergency department 4 h after ingesting an unknown quantity of a 50% emulsifiable concentration of ...
Bereda G.
europepmc +2 more sources
Molecular Modeling Studies on the Multistep Reactivation Process of Organophosphate-Inhibited Acetylcholinesterase and Butyrylcholinesterase. [PDF]
Biomolecules, 2021 Poisoning with organophosphorus compounds used as pesticides or misused as chemical weapons remains a serious threat to human health and life.
Jończyk J +6 more
europepmc +3 more sources
Synthesis, in vitro screening and molecular docking of isoquinolinium-5-carbaldoximes as acetylcholinesterase and butyrylcholinesterase reactivators [PDF]
Journal of Enzyme Inhibition and Medicinal Chemistry, 2020 The series of symmetrical and unsymmetrical isoquinolinium-5-carbaldoximes was designed and prepared for cholinesterase reactivation purposes. The novel compounds were evaluated for intrinsic acetylcholinesterase (AChE) or butyrylcholinesterase (BChE ...
David Malinak +13 more
doaj +2 more sources