Results 301 to 310 of about 67,898 (346)

Occludin: Structure, function and regulation

Advanced Drug Delivery Reviews, 2005
Epithelial and/or endothelial barriers play a critical role in animal, including human, life forms. The tight junction (TJ) is an essential component of these barriers. Occludin is a major component of the TJ. The structure of occludin, including its gene splice variants and protein essential components have been elucidated.
James M Mullin
exaly   +3 more sources

Claudin-1 and -2: Novel Integral Membrane Proteins Localizing at Tight Junctions with No Sequence Similarity to Occludin

Journal of Cell Biology, 1998
Occludin is the only known integral membrane protein localizing at tight junctions (TJ), but recent targeted disruption analysis of the occludin gene indicated the existence of as yet unidentified integral membrane proteins in TJ.
Mikio Furuse
exaly   +2 more sources

Occludin Phosphorylation in Regulation of Epithelial Tight Junctions [PDF]

Annals of the New York Academy of Sciences, 2009
Occludin is the first transmembrane protein of the tight junction to be discovered. While numerous studies emphasized the important role of occludin in assembly and maintenance of tight junctions, occludin knockout studies indicated that it was not required for tight junction assembly in different epithelia.
RadhaKrishna Rao
exaly   +3 more sources

IL1B Increases Intestinal Tight Junction Permeability by Upregulation of MIR200C-3p, Which Degrades Occludin mRNA.

Gastroenterology, 2020
BACKGROUND & AIMS Defects in the epithelial tight junction (TJ) barrier contribute to development of intestinal inflammation associated with diseases. Interleukin 1 beta (IL1B) increases intestinal permeability in mice. We investigated microRNAs that are
Manmeet Rawat, M. Nighot, Rana Al-Sadi, Y. Gupta, D. Viszwapriya, G. Yochum, W. Koltun, T. Ma   +7 more
semanticscholar   +1 more source

Tetrandrine attenuates intestinal epithelial barrier defects caused by colitis through promoting the expression of Occludin via the AhR‐miR‐429 pathway

The FASEB Journal, 2021
The elevated intestinal permeability due to mucosal barrier defects is not only secondary to inflammatory bowel disease but also precedes enteritis. Tetrandrine, a bisbenzyl isoquinoline alkaloid isolated from the dried roots of Stephamis tetlandra S ...
Yuyao Chu, Yanrong Zhu, Yajing Zhang, Xiaojing Liu, Yi-zhen Guo, Lan Chang, Xinming Yun, Zhifeng Wei, Yufeng Xia, Yue Dai   +9 more
semanticscholar   +1 more source

Redox-sensitivity of the dimerization of occludin

Cellular and Molecular Life Sciences, 2009
Occludin is a self-associating transmembrane tight junction protein affected in oxidative stress. However, its function is unknown. The cytosolic C-terminal tail contains a coiled coil-domain forming dimers contributing to the self-association. Studying the hypothesis that the self-association is redox-sensitive, we found that the dimerization of the ...
Walter, Juliane K., Castro, Victor Manuel, Voss, Martin, Gast, Klaus, Rueckert, Christine, Piontek, Jörg, Blasig, Ingolf E.   +6 more
openaire   +3 more sources

Arsenite-induced downregulation of occludin in mouse lungs and BEAS-2B cells via the ROS/ERK/ELK1/MLCK and ROS/p38 MAPK signaling pathways.

Toxicology Letters, 2020
Occludin is an important tight junction (TJ) protein in pulmonary epithelial cells. In this study, we identified changes in occludin in arsenic-induced lung injury in vivo and in vitro.
Yingqi Liu, Jing Tang, Jiaming Yuan, C. Yao, K. Hosoi, Yu Han, Shali Yu, Haiyan Wei, Gang Chen   +8 more
semanticscholar   +1 more source

Occludin confers adhesiveness when expressed in fibroblasts

Journal of Cell Science, 1997
ABSTRACT Occludin is an integral membrane protein specifically associated with tight junctions. Previous studies suggest it is likely to function in forming the intercellular seal. In the present study, we expressed occludin under an inducible promotor in occludin-null fibroblasts to determine whether this protein confers intercellular ...
C M, Van Itallie, J M, Anderson
openaire   +2 more sources

Shear stress regulates occludin content and phosphorylation

American Journal of Physiology-Heart and Circulatory Physiology, 2001
Previous studies determined that shear stress imposed on bovine aortic endothelial cell (BAEC) monolayers increased the hydraulic conductivity ( LP); however, the mechanism by which shear stress increases LPremains unknown. This study tested the hypothesis that shear stress regulates paracellular transport by altering the expression and phosphorylation
L, DeMaio, Y S, Chang, T W, Gardner, J M, Tarbell, D A, Antonetti   +4 more
openaire   +2 more sources