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Machine Learning-Driven Automated Culture Reveals Similar Performance of mTeSR+ and StemFlex in Human iP11N Pluripotent Stem Cells. [PDF]

Cells
Bogoniewski AA, Gonzalez MF, Reyes RE, Rivera SF, Taylor C, Schurr T, Damoiseaux R, Lipshutz GS.   +7 more
europepmc   +1 more source

The role of pluripotency regulators in triple-negative breast cancer immune response. [PDF]

Front Genet
López-Santana C, Mendez-Rivera F, Bernal-Estévez DA.   +2 more
europepmc   +1 more source

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G-quadruplex formation in the Oct4 promoter positively regulates Oct4 expression

Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms, 2017
The Oct4 gene codes for a transcription factor that plays a critical role in the maintenance of pluripotency in embryonic and cancer stem cells. Its expression thus has to be tightly regulated. We performed biophysical characterization of the promoter region using a combination of UV absorption, CD, and NMR spectroscopies, native PAGE and chemical ...
Daniel, Renčiuk, Jan, Ryneš, Iva, Kejnovská, Silvie, Foldynová-Trantírková, Michael, Andäng, Lukáš, Trantírek, Michaela, Vorlíčková   +6 more
openaire   +2 more sources

Oct4 pseudogenes are transcribed in cancers

Biochemical and Biophysical Research Communications, 2005
Octamer-binding transcription factor 4 (Oct4) plays a critical role for maintaining pluripotent and the self-renewing state of stem cells. Recent studies demonstrated that Oct4 gene was expressed in human cancers. Six pseudogenes of Oct4 have been proposed by using bioinformatics approach to analyze the genomic nucleotide sequences.
Guangli, Suo, Jin, Han, Xia, Wang, Jingyu, Zhang, Yannan, Zhao, Yanhong, Zhao, Jianwu, Dai   +6 more
openaire   +2 more sources

Oct4 is required for primordial germ cell survival [PDF]

EMBO Reports, 2004
Previous studies have shown that Oct4 has an essential role in maintaining pluripotency of cells of the inner cell mass (ICM) and embryonic stem cells. However, Oct4 null homozygous embryos die around the time of implantation, thus precluding further analysis of gene function during development.
Hilda Lomelí, Alexey Tomilin, Maurizio Pesce   +2 more
exaly   +3 more sources

Potential Role of OCT4 in Leukemogenesis

Stem Cells and Development, 2017
Embryonic stem cells typically show properties of long-term self-renewal and lack of differentiation. When appropriately stimulated, they are able to differentiate into all cell lineages, and lose their self-renewal characteristics. These properties are controlled by a series of genes encoding several transcription factors, including OCT4, the product ...
Tiphanie, Picot, Sanae, Kesr, Yuenv, Wu, Carmen Mariana, Aanei, Pascale, Flandrin-Gresta, Sylvie, Tondeur, Emmanuelle, Tavernier, Eric, Wattel, Denis, Guyotat, Lydia, Campos   +9 more
openaire   +2 more sources