H3K9me2 is a determinant for the mitosis-to-meiosis transition in female germ cells. [PDF]
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Spatial heterogeneity of lactylation: insights into gene expression, metabolism, and lactate transport in human embryonic stem cells. [PDF]
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Synergistic increase in anti-cancer stemness activity and pro-apoptotic effects in human glioblastoma cancer stem-like cells by combination treatment with temozolomide and corosolic acid. [PDF]
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SPP1 promotes cancer stemness and reduces osimertinib sensitivity in non-small cell lung cancer through interactions with CD44. [PDF]
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Quantifying human pluripotent stem cell attributes with population balance modeling. [PDF]
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Oct4 clusters promote DNA accessibility by enhancing chromatin plasticity
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G-quadruplex formation in the Oct4 promoter positively regulates Oct4 expression
Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms, 2017The Oct4 gene codes for a transcription factor that plays a critical role in the maintenance of pluripotency in embryonic and cancer stem cells. Its expression thus has to be tightly regulated. We performed biophysical characterization of the promoter region using a combination of UV absorption, CD, and NMR spectroscopies, native PAGE and chemical ...
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