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Oct4 pseudogenes are transcribed in cancers
Biochemical and Biophysical Research Communications, 2005Octamer-binding transcription factor 4 (Oct4) plays a critical role for maintaining pluripotent and the self-renewing state of stem cells. Recent studies demonstrated that Oct4 gene was expressed in human cancers. Six pseudogenes of Oct4 have been proposed by using bioinformatics approach to analyze the genomic nucleotide sequences.
Guangli, Suo +6 more
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Oct4 is required for primordial germ cell survival [PDF]
EMBO Reports, 2004 Previous studies have shown that Oct4 has an essential role in maintaining pluripotency of cells of the inner cell mass (ICM) and embryonic stem cells. However, Oct4 null homozygous embryos die around the time of implantation, thus precluding further analysis of gene function during development.
Elena Tolkunova +2 more
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Potential Role of OCT4 in Leukemogenesis
Stem Cells and Development, 2017Embryonic stem cells typically show properties of long-term self-renewal and lack of differentiation. When appropriately stimulated, they are able to differentiate into all cell lineages, and lose their self-renewal characteristics. These properties are controlled by a series of genes encoding several transcription factors, including OCT4, the product ...
Tiphanie, Picot +9 more
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Expression and significance of Oct4 in bladder cancer
Journal of Huazhong University of Science and Technology [Medical Sciences], 2007In order to detect the expression of Oct4 in bladder cancer tissue and cell line BIU-87, immunohistochemistry was used in 49 bladder cancer biopsy samples and immunofluorescence and reverse transcription-PCR were performed on bladder cancer cell line BIU-87.
Kai Xu +3 more
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PIAS Proteins as Repressors of Oct4 Function
Journal of Molecular Biology, 2007The POU domain transcription factor Oct4 plays essential functions in the maintenance of pluripotent embryonic and germ cells of mammals. Molecular mechanisms of Oct4 action remain poorly understood. To isolate modulators of Oct4 activity, we performed a yeast two-hybrid screen with the Oct4 POU domain as a bait and isolated PIASy as an Oct4 ...
Tolkunova, E. +5 more
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Establishment of oct4:egfp transgenic and oct4:egfp /β-actin:DsRed double transgenic medaka lines
In Vitro Cellular & Developmental Biology - Animal, 2016As a model to examine cellular multipotency in fish, we established a medaka transgenic (Tg) Tru.oct4:egfp line carrying the green fluorescence protein (GFP) cDNA under control of the Takifugu rubripes oct4 promoter. In this Tg line, GFP could be used to examine both maternal and zygotic oct4 expression during embryogenesis. In addition, while adult Tg
Shinpei, Yokota +6 more
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The International Journal of Biochemistry & Cell Biology, 2020
SALL4 and OCT4, along with other pluripotency-associated transcription factors, play critical roles in maintaining embryonic stem cell pluripotency and self-renewal. Ku80 is a component of the protein complex called DNA-dependent protein kinase, which mainly involved in DNA double-strand break repair.
Bixing Zhao +12 more
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SALL4 and OCT4, along with other pluripotency-associated transcription factors, play critical roles in maintaining embryonic stem cell pluripotency and self-renewal. Ku80 is a component of the protein complex called DNA-dependent protein kinase, which mainly involved in DNA double-strand break repair.
Bixing Zhao +12 more
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Prognostic significance of expression of myogenin and OCT4 in glioma
Minerva Pediatrics, 2018Glioma is the most common extracranial solid tumor of children. The malignant (cancer) cells form in neural crest cell of the adrenal gland. In this study we investigate the expressions of myogenin and OCT4 in Glioma which might be used as prognostic makers for this deteriorated disease.We used Quantitative Fluorescence PCR (QF-PCR), Enzyme-linked ...
Nuo, Zheng, Dongli, Zhang, Xiaoming, Liu
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Medecine sciences : M/S, 2010
OCT4 encoded by pou5f1 is one of the most ancient and early transcription factors identified in the embryo. It has been longwise recognized as a gatekeeper for pluripotency of embryonic stem (ES) cell. Uncovered twenty years ago, its fame was built up from its key role in maintaining embryonic stem cell pluripotency in 1998. Since, OCT4 was reported to
Sonia, Stefanovic, Michel, Pucéat
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OCT4 encoded by pou5f1 is one of the most ancient and early transcription factors identified in the embryo. It has been longwise recognized as a gatekeeper for pluripotency of embryonic stem (ES) cell. Uncovered twenty years ago, its fame was built up from its key role in maintaining embryonic stem cell pluripotency in 1998. Since, OCT4 was reported to
Sonia, Stefanovic, Michel, Pucéat
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A unique Oct4 interface is crucial for reprogramming to pluripotency
Nature Cell Biology, 2013Terminally differentiated cells can be reprogrammed to pluripotency by the forced expression of Oct4, Sox2, Klf4 and c-Myc. However, it remains unknown how this leads to the multitude of epigenetic changes observed during the reprogramming process. Interestingly, Oct4 is the only factor that cannot be replaced by other members of the same family to ...
Vom Bruch, Hermann +12 more
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