Results 41 to 50 of about 37,080 (198)

Automated GMP compliant production of [18F]AlF-NOTA-octreotide

EJNMMI Radiopharmacy and Chemistry, 2020
Background Gallium-68 labeled synthetic somatostatin analogs for PET/CT imaging are the current gold standard for somatostatin receptor imaging in neuroendocrine tumor patients.
Térence Tshibangu, Christopher Cawthorne, Kim Serdons, Elin Pauwels, Willy Gsell, Guy Bormans, Christophe M. Deroose, Frederik Cleeren   +7 more
doaj   +1 more source

Phase 3 Trial of 177Lu-Dotatate for Midgut Neuroendocrine Tumors [PDF]

, 2017
Background Patients with advanced midgut neuroendocrine tumors who have had disease progression during first-line somatostatin analogue therapy have limited therapeutic options.
Al‐nahhas, A, Ansquer, C, Anthony, L, Azevedo, I, Baudin, E, Baum, Rp, Baum, Rp, Benson, A, Benson, Ab, Berlin, J, Berlin, J, Bodei, L, Brianzoni, E, Bushnell, D, Bushnell, D, Caplin, M, Caplin, M, Chasen, B, Chiara Grana, M, Courbon, F, DELLE FAVE, Gianfranco, Delpassand, E, Delpassand, E, El Haddad, G, Erion, Jl, Freemantle, N, Garbus, S, Giammarile, F, Grande, E, Grande, E, Grossman, A, Hendifar, A, Hendifar, A, Hobday, T, Hobday, T, Jacene, H, Krenning, E, Kulkarni, Hr, Kulke, M, Kulke, Mh, Kunz, Pl, Kvols, L, Kwekkeboom, D, Lebtahi, R, Lopera Sierra, M, Manoharan, P, Mariani, G, Metz, D, Mittra, E, Mittra, E, Mora, J, Mora, J, Morse, M, O'Dorisio, Tm, Pavel, M, Pavel, M, Reed, N, Reed, N, Rindi, G, Ruszniewski, P, Ruszniewski, P, Santoro, P, Scheidhauer, K, Schipper, M, Seregni, E, Seregni, E, Severi, S, Srirajaskanthan, R, Srirajaskanthan, R, Strosberg, J, Strosberg, J, Sundin, A, Taieb, D, Thevenet, T, Van Cutsem, E, Van Cutsem, E, Weber, M, Wolin, E, Wolin, E, Yao, J, Yao, J., Öberg, K, Öberg, K   +82 more
core   +1 more source

Circuit dissection of the role of somatostatin in itch and pain [PDF]

, 2018
Stimuli that elicit itch are detected by sensory neurons that innervate the skin. This information is processed by the spinal cord; however, the way in which this occurs is still poorly understood.
AJ Christensen, AJ Todd, Allen C. Dickie, AM Bell, Andrew J. Todd, AP Kardon, B Duan, BL Roth, BN Armbruster, C Peirs, C Solorzano, CE Pichon Le, CL Li, D Bröhl, D Usoskin, DM Bautista, DP Roberson, DR Simmons, E Foster, E Polgár, E Vasyutina, Erika Polgár, F Cevikbas, F Proudlock, GR Dressler, H Petitjean, H Taniguchi, Hanns Ulrich Zeilhofer, Hans Jürgen Solinski, Hendrik Wildner, I Bencivinni, IM Chiu, J Braz, J Chrubasik, Jing Huang, JL Hylden, John S. Riddell, KA Boyle, Kieran A. Boyle, KK Stantcheva, L Cui, L Han, L Li, L Madisen, L Madisen, M Gutierrez-Mecinas, M Gutierrez-Mecinas, M Gutierrez-Mecinas, Mark A. Hoon, Masahiko Watanabe, Mette C. Kriegbaum, MJ Krashes, MQ Nguyen, Noboru Iwagaki, P Taurà, Pang-Yen Tseng, PS Danielian, RJ Mullen, S Sun, Santosh K. Mishra, SE Ross, SK Mishra, SK Mishra, SK Mishra, SM Carlton, SM Carlton, SR Chaplan, T Akiyama, T Hökfelt, T Hökfelt, T Lee, T Yasaka, T Zeyda, V Chapman, VE Abraira, VS Seybold, Y Lu, YG Sun, YG Sun, Z Wiesenfeld-Hallin   +79 more
core   +1 more source

Liquid Crystalline Inverted Lipid Phases and Reverse Micelles in Drug Delivery: From Molecular Design to Therapeutic Potential

Advanced Functional Materials, EarlyView.
Liquid crystalline inverted lipid phases and reverse micelles are self‐assembled lipid nanostructures that enhance the solubility, stability, and delivery of diverse therapeutics. This review integrates their physicochemical principles, formulation strategies, drug loading mechanisms, and biomedical applications, highlighting their growing ...
Numan Eczacioglu, Mulazim Hussain Asim, Soheil Haddadzadegan, Andreas Bernkop‐Schnürch   +3 more
wiley   +1 more source

Acromegaly: pathogenesis & treatment [PDF]

, 2019
Acromegaly is a multi-system disorder whose etiology is most often traced back to a growth hormone-secreting pituitary adenoma (PA). Growth hormone (GH) secretion promotes insulin-like growth factor 1 (IGF-1) release from peripheral tissues, leading to ...
Tilvawala, Megha
core  

Strategies for Loading and Releasing Peptide Therapeutics in Biodegradable Carriers

Advanced Functional Materials, EarlyView.
A biodegradable carrier‐based peptide delivery system is a powerful treatment platform for diverse diseases, owing to its superior therapeutic efficacy and low toxicity. This review examines the conventional peptide‐loaded carrier fabrication process and its current limitations.
Wookyoung Jang, Ki Wan Bong
wiley   +1 more source

Calcium Channel Blockers Inhibit Pancreatic Neuroendocrine Neoplasms Progression via Cav1.2‐Epigenetic Circuit

Advanced Science, EarlyView.
Our study reveals a novel mechanism of a positive regulatory circuit between Cav1.2 and H3K27ac for pancreatic neuroendocrine neoplasms (pNENs) progression. Cav1.2 is identified as a crucial target for promoting disease progression and correlates with malignant behaviors, which are remarkably inhibited by the administration of calcium channel blockers (
Yangyinhui Yu, Qiongcong Xu, Jinzhao Xie, Mingjian Ma, Xitai Huang, Yinhao Shi, Jiawei Zhou, Enliang Zhu, Ziyi Zhao, Ning Zhang, Zhide Liu, Jingyuan Ye, Xiaoyu Yin   +12 more
wiley   +1 more source

Role of octreotide and instillation of povidone-iodine in the treatment of lymphorrhea in renal transplantation: A comparative study

Indian Journal of Transplantation
Background: Lymphorrhea is a minor complication after kidney transplantation but may develop into a lymphocele and prolong hospital stay. Treatment is conservative based on percutaneous drainage until lymphatic leakage cessation.
Vaibhav Kant Baderiya, Dilip Kumar Pal, Atanu Pal   +2 more
doaj   +1 more source

Elevated miR-16-5p induces somatostatin receptor 2 expression in neuroendocrine tumor cells.

PLoS ONE, 2020
Somatostatin analogs, which are used to treat neuroendocrine tumors, inhibit hormone secretion or promote tumor shrinkage; however, their efficacy varies between patients, possibly because of differential expression of somatostatin receptors (SSTRs) in ...
HanHee Jo, Yusun Park, Jisu Kim, Hyeonjeong Kwon, Taehun Kim, JongSook Lee, Jae-Chul Pyun, Misu Lee, Mijin Yun   +8 more
doaj   +1 more source

Synchronous primary papillary breast cancer, medullary thyroid carcinoma and neuroendocrine tumor in postmenopausal woman. [PDF]

, 2016
Multiple endocrine neoplasia are syndromes involving two or more endocrine tissues, often correlated to RET proto-oncogene mutations. We herein present the first reported case of a 57-years-old woman with three synchronous primary cancers of breast ...
DE IULIIS, Francesca, Lanza, Rosina, Lunardi, Gianluigi, Menghi, Antonello, Pecorella, Irene, Rossi, Lorena, Scarpa, Susanna, Sini, Valentina   +7 more
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