Results 71 to 80 of about 858,764 (131)

Table_1_circKLF4 Upregulates Klf4 and Endoglin to Promote Odontoblastic Differentiation of Mouse Dental Papilla Cells via Sponging miRNA-1895 and miRNA-5046.xlsx

, 2022
circular RNAs (circRNAs) is a broad and diverse endogenous subfamily of non-coding RNAs, regulating the gene expression by acting as a microRNA (miRNA) sponge.
Yue Zhang (30585), Guobin Yang (420939), Guohua Yuan (420938), Hao Zhang (15339)   +3 more
core   +1 more source

Single‐Nucleotide Polymorphisms in Calcium and Vitamin D Maintenance Genes Association With Tooth Size

Clinical and Experimental Dental Research, Volume 12, Issue 5, October 2026.
ABSTRACT Objectives This study investigated the association between Single Nucleotide Polymorphisms (SNPs) in calcium and vitamin D maintenance genes and mesiodistal tooth size (MTS) of permanent teeth. Materials and Methods A total of 108 patients undergoing orthodontic treatment were recruited.
Lucas Cabral Rodrigues, Mirian Aiko Nakane Matsumoto, Maria Bernadete Sasso Stuani, Guido Artemio Marañón‐Vásquez, Fábio Lourenço Romano, Daniela Silva Barroso de Oliveira, Juliane Cora da Silva, Flares Baratto‐Filho, Christian Kirschneck, Erika Calvano Küchler, Caio Luiz Bitencourt Reis   +10 more
wiley   +1 more source

The Role of Neuropeptide Y in Dental Pulp: Balancing Neurogenic Inflammation and Pain Modulation

International Endodontic Journal, Volume 59, Issue 10, Page 2028-2045, October 2026.
ABSTRACT Background Dental pulp is a densely innervated, low‐compliance tissue in which neurogenic inflammation can rapidly escalate into oedema, raised intrapulpal pressure, microvascular compromise, and pain. While Substance P (SP) and Calcitonin gene‐related peptide (CGRP) are well‐established drivers of pulp vasodilation, the Neuroopeptide Y (NPY ...
Javier Caviedes‐Bucheli, Esteban Ulate, Hugo‐Roberto Munoz, Nestor Ríos‐Osorio   +3 more
wiley   +1 more source

Dentine Regeneration With Calcium Strontium Silicate: In Vitro Odontogenic Differentiation, Antimicrobial Activity, Immunomodulation and In Vivo Pulpotomy in Rat Molars

International Endodontic Journal, Volume 59, Issue 9, Page 1871-1886, September 2026.
ABSTRACT Aim This study examined the in vitro and in vivo performance of calcium strontium silicate (CSR) as a novel biomaterial for vital pulp therapy (VPT), assessing its odontogenic differentiation, antibacterial activity, immunomodulation, inflammatory response and dentine regeneration potential compared to calcium silicate (CS) and Mineral ...
Mohamed Mahmoud Abdalla, Vidhyashree Rajasekar, Heba Ahmed, Mengyu Huang, Cynthia Kar Yung Yiu   +4 more
wiley   +1 more source

Phenotyping of Human Pulp Cells After Cryopreservation

Journal of Cellular and Molecular Medicine, Volume 30, Issue 18, September 2026.
ABSTRACT This study aimed to compare cell viability, morphology, cell yield, and stem cell‐associated marker expression of cryopreserved human dental pulp cells (HDPCs) across different passages following thawing and serial in vitro expansion. HDPCs were isolated from three healthy donors, cryopreserved at −80°C for 3 months, and subsequently evaluated
Camila Maura Morais Lima dos Santos, Washington Henrique Themoteo da Silva, Fernanda Rodrigues Guedes, Milla Christian de Paula, Leslie Morse, Ricardo Battaglino, Marcelo José Barbosa Silva, Ana Paula Turrioni   +7 more
wiley   +1 more source

Fabrication and Characterization of a Trans‐Activator of Transcription Peptide–Functionalized Collagen–Mineral Trioxide Aggregate Nanofiber Scaffold: Physicochemical Properties and Fibroblast Response

Clinical and Experimental Dental Research, Volume 12, Issue 4, August 2026.
ABSTRACT Objectives Electrospun nanofibrous scaffolds that mimic extracellular matrix (ECM) architecture are promising for endodontic and craniofacial tissue engineering. This study aimed to fabricate a composite electrospun scaffold comprising poly(ε‐caprolactone) (PCL), collagen, mineral trioxide aggregate (MTA), and a TAT cell‐penetrating peptide ...
Mehdi Sheikharabi, Javad Delkabadi, Ayyoob Khosravi, Ezatolah Kazeminejad   +3 more
wiley   +1 more source

Single‐Cell Virtual Perturbation Screening Identifies STAT3 as a Key Regulator of Dentinogenesis

Cell Proliferation, Volume 59, Issue 8, August 2026.
STAT3 promotes odontoblast differentiation in dental mesenchymal cells by transcriptionally regulating WNT2B via the canonical Wnt/β‐catenin signalling pathway. These findings elucidate a mechanism underlying dentine development. ABSTRACT Dentine formation constitutes a physiological process precisely regulated by signal transduction modules governing ...
Yanfei Zhu, Hongyuan Xu, Zijian Zhang, Siyuan Sun, Zihan Huang, Xin Gao, Houwen Pan, Xiangru Huang, Yuanqi Liu, Xinyu Wang, Hanbin Jia, Qinggang Dai, Lingyong Jiang   +12 more
wiley   +1 more source

Human Dental Pulp Stem Cells via the NF-κB Pathway

Cellular Physiology and Biochemistry, 2015
Background/Aims: Odontogenic differentiation of human dental pulp stem cells (HDPSCs) is regulated by multiple factors and signaling molecules. However, their regulatory mechanisms are not completely understood. In this study, we investigated the role of
Shensheng Gu, Shujun Ran, Feng Qin, Dong Cao, Jia Wang, Bin Liu, Jingping Liang   +6 more
doaj   +1 more source

Molecular Signatures of Peripheral and Central Dental Pulp Subpopulations in Response to Streptococcus mutans: A Bulk RNA‐Seq Analysis

International Endodontic Journal, Volume 59, Issue 7, Page 1402-1415, July 2026.
ABSTRACT Aim The dental pulp is an immunologically active tissue that responds dynamically to cariogenic challenge. Peripheral pulp cells adjacent to dentine encounter bacterial stimuli earlier than cells located in the central pulp. To investigate signalling and immune interactions, this study profiled the transcriptomes of dentine‐adherent cells ...
Sandra Pohl, Maximilian L. Huber, Tobias Akamp, Andreas Rosendahl, Melanie Linnebank, Lea Schreiber, Claudia Gebhard, Nicholas Strieder, Michael Rehli, Wolfgang Buchalla, Matthias Widbiller   +10 more
wiley   +1 more source

In Vitro Evaluation of Novel Calcium Silicate‐Based and Resin‐Modified Calcium Silicate Materials: Cytocompatibility and Mineralization Potential on Human Dental Pulp Stem Cells for Pulp Repair

Microscopy Research and Technique, Volume 89, Issue 6, Page 932-947, June 2026.
This study demonstrates that Biodentine XP exhibits superior cytocompatibility, promotes odontogenic differentiation, and enhances mineralization in human dental pulp stem cells, supporting its use in regenerative endodontics. Resin‐modified materials showed lower bioactivity, highlighting the importance of material composition in pulp therapy outcomes.
Francisco Javier Rodríguez‐Lozano, Nuria Pérez‐Guzmán, Paula García‐Rios, David García‐Bernal, Adrián Lozano, Sergio López‐García   +5 more
wiley   +1 more source