Results 81 to 90 of about 858,764 (131)

MARCH2 suppresses odontoblast differentiation by polyubiquitinating PTPRD

International Journal of Oral Science
Dentin, the main component of dental hard tissues, is produced by differentiated odontoblasts. How odontoblast differentiation is regulated remains understudied. Here, we screen that the expression of membrane-associated RING finger protein 2 (March2) is
Hao Feng, Jiaxin Niu, Zhi Chen, Guobin Yang, Guohua Yuan   +4 more
doaj   +1 more source

Erk1/2-Nf-Κb Crosstalk Mediates Mechanoregulation Of Dpscs

International Dental Journal
Aim or purpose: To elucidate how dynamic hydrostatic pressure regulates dental pulp stem cells(DPSCs) behavior and the response mechanisms of ERK1/2 and NF-κB signaling pathways.
Yuting Sun, Jian Zhang, Jiayuan Wu
doaj   +1 more source

Tβ4 mRNA and protein expression during odontoblastic differentiation of HDPCs.

, 2013
Cells were cultured in OM containing 10 mM β-glycerophosphate, 50 µg/ml ascorbic acid, and 100 nM dexamethasone for 0, 1, 3, 7 or 14 days. (A) Tβ4 mRNA expression was followed by RT-PCR relative to GAPDH expression (top) and by Western blotting relative ...
Sang-Im Lee (403297), Eun-Cheol Kim (36621), Hwa-Jeong Lee (36617), Duck-Su Kim (403298), Hee-Jae Cha (247076)   +4 more
core   +1 more source

VPA Enhances Pulp Regeneration by Regulating LPS-Induced Human Dental Pulp Stem Cells Odontogenic Differentiation

International Dental Journal
Aim: This study aimed to investigate the effect of valproic acid (VPA) exposure on pulp inflammation and regeneration. Methods: The effects of VPA on pulp regeneration and reparative dentin formation were examined using cone-beam computed tomography ...
Zhihua Wang, Minghao Wang, Zhirong Luo, Yi Fu, Xiaomiao Zhu, Dongyu Li, Wenkai Jiang, Xiaogang Cheng, Chengxiong Cai, Xiaoru Zhu, Paul R. Cooper, Shengchao Wang, Wenxi He   +12 more
doaj   +1 more source

LPS promote the odontoblastic differentiation of human dental pulp stem cells via MAPK signaling pathway

, 2015
Human dental pulp stem cells (hDPSCs) show significant potential for exploitation in novel regeneration strategies, although lack of understanding of their responses to bacterial challenge constrains their application.
Yu, Qing, Zeyuan Zhou, Wang, Zhihua, Qing Yu, Yaqing Zhang, Zhou, Zeyuan, Zhirong Luo, Jiang, Yong, Smith, Tony, Wenxi He, Zhang, Yaqing, Zhihua Wang, Paul R. Cooper, He, Wenxi, Yong Jiang, Cooper, Paul, Luo, Zhirong, Anthony J. Smith   +17 more
core   +1 more source

Knockdown of β-catenin inhibits odontoblastic differentiation of DPCs.

, 2014
(A) DPCs transfected with shRNA-NT or shRNA-β-cat on day 14 after transfection (EGFP positive). (B, C, D, E, F, G) Effects of shRNA-β-cat on the mRNA expression of β-catenin, DSPP, DMP1, ALP, BSP and OCN after odontoblastic induction, respectively. GAPDH
Yong Zheng (420246), Yun Niu (85792), Nana Han (521517), Ran Li (57928), Xianyu Li (492675), Qi Zhang (28502), Mi Zhou (9884)   +6 more
core   +1 more source

Circ-AARS plays an important role during the odontogenic differentiation of dental pulp stem cells by modulating miR-24-3p/KLF6 expression

Stem Cell Research & Therapy
Background Circular RNAs (circRNAs) play a crucial role in stem cell-based tooth regeneration. However, the functions and underlying mechanisms of circRNAs in tooth regeneration from human dental pulp stem cells (DPSCs) remain largely unclear. Methods In
Meizhi Sui, Jiaxuan Lyu, Jiaxin Zhou, Qian Liao, Zexu Xiao, Mingming Jin, Jiang Tao   +6 more
doaj   +1 more source

The Influence Of MYDGF On The Osteogenic Differentiation Of DPSCs

International Dental Journal
Aim or purpose: Bone marrow-derived growth factors, as positive regulators of bone homeostasis, can participate in the regulation of bone metabolism.
Mangnan Liu
doaj   +1 more source

Odontoblastic differentiation of iPS cells on CS/BMP-4.

, 2013
(A) Immunofluorescence staining for the odontoblastic cell marker, dentin sialoprotein (DSP). Images show iPS cells (a, b) and E14Tg2a cells (c, d) that are undifferentiated (a, c) or differentiated using CS/BMP-4 (b, d). Scale bars = 25 μm.
Rie Kawai (482379), Hiroshi Nakamura (8789), Hideyuki Yamaguchi (482380), Makio Mogi (482378), Kazuhiko Nakata (482382), Nobuaki Ozeki (482377), Taiki Hiyama (482381)   +6 more
core   +1 more source

H19 Promotes Odontogenic Differentiation of Human Dental Pulp Cells via miR-103a-3p-Mediated PIK3R1/AKT and KLF4 Pathways

International Dental Journal
Background: The regeneration of functional dentin is a critical clinical goal for preserving tooth vitality after injury, with odontoblastic differentiation of human dental pulp stem cells (hDPSCs) being central to this reparative process. While the long
Jingkun Zhang, Li Lin, Huixian Dong, Bingtao Wang, Xiaoshi Chen, Chenhao Wang, Liecong Lin, Jialin Zhong, Guocong Zheng, Qianzhou Jiang   +9 more
doaj   +1 more source