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Molecular basis of dental sensitivity: The odontoblasts are multisensory cells and express multifunctional ion channels

open access: yesAnnals of Anatomy, 2018
Odontoblasts are the dental pulp cells responsible for the formation of dentin. In addition, accumulating data strongly suggest that they can also function as sensory cells that mediate the early steps of mechanical, thermic, and chemical dental ...
J Cobo, JOSÉ A Vega
exaly   +3 more sources
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Expression of amelogenin in odontoblasts

Bone, 2003
Amelogenin is the major enamel protein produced by ameloblasts. Its expression has been shown to be down-regulated in ameloblasts of vitamin-D-deficient (-D) rats. The potential expression and localization of amelogenin in odontoblasts and its regulation by vitamin D were investigated in this study.
Mary Macdougall   +2 more
exaly   +3 more sources

PIEZO1 Ion Channels Mediate Mechanotransduction in Odontoblasts

open access: yesJournal of Endodontics, 2022
INTRODUCTION Odontoblasts, terminally differentiated dentin-forming cells with their processes that penetrate into dentin, have been considered potential sensory cells.
Liuyan Meng, Zhuan Bian
exaly   +2 more sources

S100A4 is expressed in human odontoblasts and odontoblast-like cells

Tissue and Cell, 2022
The calcium-binding protein S100A4 has been found in fibroblasts in many tissues. It has been well studied in the regulating process of inflammation and tumor metastasis. However, as a calcium regulating protein, its expression in the dental pulp has not yet been elucidated.
Xue, Cai, Lu, Zhang, Xiaoyan, Wang
openaire   +2 more sources

Fam20C overexpression in odontoblasts regulates dentin formation and odontoblast differentiation

Journal of Molecular Histology, 2023
FAM20C phosphorylates secretory proteins at S-x-E/pS motifs, and previous studies of Fam20C-dificient mice revealed that FAM20C played essential roles in bone and tooth formation. Inactivation of FAM20C in mice led to hypophosphatemia that masks direct effect of FAM20C in these tissues, and consequently the direct role of FAM20C remains unknown.
Kohei Naniwa   +7 more
openaire   +2 more sources

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