Results 61 to 70 of about 6,765 (166)

Optimal Hypoxia Mimetic Small Molecules for Enhancing Angiogenic Properties of Stem Cells From Human Exfoliated Deciduous Teeth

International Endodontic Journal, Volume 59, Issue 10, Page 2122-2142, October 2026.
ABSTRACT Aim Hypoxic preconditioning of cells holds promise for regenerative therapies, yet identifying effective and safe methods for clinical application remains challenging. We aimed to determine optimal hypoxia‐mimetic small molecules (SMs) that stabilize hypoxia‐inducible factor‐1α (HIF‐1α) and their dosages for hypoxic preconditioning in stem ...
Hong Wang, Jiawei Liu, Xintao Yang, Mohamad Koohi‐Moghadam, Shuting Gao, Yuanyuan Han, Dineshi Sewvandi Thalakiriyawa, James Kit Hon Tsoi, Yanqi Yang, Waruna Lakmal Dissanayaka   +9 more
wiley   +1 more source

Cathepsin K‐Positive Cell Lineage Promotes In Situ Dentin Formation Controlled by Nociceptive Sonic Hedgehog

Advanced Science
Oral diseases affect nearly half of the global population throughout their lifetime causing pain, as estimated by the World Health Organization. Preservation of vital pulp is the therapeutic core as well as a challenge to protect natural teeth.
Ruoshi Xu, Xiaohan Zhang, Weimin Lin, Yushun Wang, Danting Zhang, Shuang Jiang, Linfeng Liu, Jiaying Wang, Xutao Luo, Xiao Zhang, Junjun Jing, Quan Yuan, Chenchen Zhou   +12 more
doaj   +1 more source

Regulators of Collagen Fibrillogenesis during Molar Development in the Mouse

Frontiers in Physiology, 2017
Development of mammalian teeth and surrounding tissues includes time–space changes in the extracellular matrix composition and organization. This requires complex control mechanisms to regulate its synthesis and remodeling.
Ivana Zvackova, Eva Matalova, Eva Matalova, Herve Lesot, Herve Lesot   +4 more
doaj   +1 more source

Radiographic Screening of Wild and Semi‐Wild Cape Ground Squirrels (Geosciurus inauris) for the Presence of Peri‐Apical Masses Associated With Elodont Incisor Teeth

Zoo Biology, Volume 45, Issue 5, Page 627-637, September/October 2026.
Peri‐apical masses were absent in both wild and semi‐wild Cape ground squirrels, despite dietary differences and minor incisor trauma. These findings suggest such lesions are rare outside captivity and not induced by low‐fiber diets alone, adding to the literature on environmental and dietary risk factors in elodont tooth pathology.
Quintin Norval, Adrian Tordiffe, Gerhard Steenkamp   +2 more
wiley   +1 more source

Effects of diet and fluoride on early phases of odontogenesis in rats [PDF]

, 2000
The influence of diet and fluoride on odontogenesis in rats was investigated. 20 foetuses, 20 days old, were divided into four groups. The control group was fed with the standard diet and drank water with 0.16 mg F/l.
Adamowicz-Klepalska, Barbara, Maciejewska, Izabela; Department of Pedodontic Dentistry, Medical University of Gdańsk, Poland   +1 more
core  

Molecular mediators of odontogenesis at ectopic sites

, 1998
Odontogenesis is a well characterized model of instructive epithelial-mesenchymal interactions. Previous tissue recombinations indicate that mouse mandibular epithelium prior to E12 has odontogenic potential and can elicit tooth formation at variety of ...
Wang, Yu-Hsiung
core   +1 more source

Dental Pulp Cells Isolated from Teeth with Superficial Caries Retain an Inflammatory Phenotype and Display an Enhanced Matrix Mineralization Potential

Frontiers in Physiology, 2017
We have isolated dental pulp cells (DPCs) from three healthy (hDPCs) and three carious (cDPCs) donors and shown that compared to hDPCs cells isolated from superficial carious lesions show higher clonogenic potential; show an equivalent proportion of ...
Reem El-Gendy, Reem El-Gendy, Hanaa Alkharobi, Hanaa Alkharobi, James Beattie, Josie Meade, Deirdre Devine   +6 more
doaj   +1 more source

In Vivo Base Editing Partially Rescues Bone Dysplasia in a Mouse Model of Hutchinson‐Gilford Progeria Syndrome

Aging Cell, Volume 25, Issue 9, September 2026.
Hutchinson‐Gilford progeria syndrome (HGPS) is a premature aging disorder caused by a mutation in LMNA that produces the toxic progerin protein. In this study, an adenine base editor delivered via AAV9 achieved partial gene correction in HGPS mice when given at two weeks of age, partially rescuing bone structural and gene expression parameters and ...
Wayne A. Cabral, Caleb M. Grenko, Diana Yeritsyan, Indeevar Beeram, Shubham Laiwala, Lukas R. Johnson, Urraca L. Tavarez, Tingfen Yan, Stephen M. Wincovitch, Luke W. Koblan, Xin D. Gao, Meirui An, Narisu Narisu, Leslie G. Biesecker, David R. Liu, Ara Nazarian, Francis S. Collins, Michael R. Erdos   +17 more
wiley   +1 more source

Excess NF-κB induces ectopic odontogenesis in embryonic incisor epithelium

, 2015
Nuclear factor κB (NF-κB) signaling plays critical roles in many physiological and pathological processes, including regulating organogenesis. Down-regulation of NF-κB signaling during development results in hypohidrotic ectodermal dysplasia.
Oommen, S., Hishinuma, M., Harada, F., Ohazama, A., Lesot, H., Miake, Y., Porntaveetus, T., Inoue, J., Liu, B., Ghafoor, S., Watanabe, M., Peterkova, R., Sharpe, P. T., Nozawa-Inoue, K., Akiyama, T., Ramirez, A., Sharpe, P.T., Schmidt-Ullrich, R., Ramírez, Nomoto, T., Otsuka-Tanaka, Y., Maeda, T., Page, A., Ota, M.S., Hu, Y., Ota, M. S., Kawasaki, K., Kawasaki, M., Blackburn, J.   +28 more
core   +1 more source

FasL induces expression of Mmp13 and Osterix in bone cells

Bone Reports, 2021
Adéla Kratochvílová, Barbora Veselá, Eva Švandová, Reinhard Gruber, Eva Matalová   +4 more
doaj   +1 more source