Results 51 to 60 of about 18,586 (163)

Summarized data of genotoxicity tests for designated food additives in Japan

Genes and Environment, 2018
The Ministry of Health, Labour and Welfare has carried out genotoxicity tests for food additives used in Japan in cooperation with the Japan Food Additives Association since 1979. Hayashi et al.
Masami Yamada, Masamitsu Honma
doaj   +1 more source

Genotoxic assessment of a Cannabis sativa L. extract

Pharmaceutical Biology
Context As a naturally occurring terpenoid found in Cannabis sativa L. (Cannabaceae), cannabidiol (CBD) has gained public and industry interest for the purposes of personal well-being as a foodstuff and pharmaceutical. Despite a number of publications on
Mark J. Tallon, Robert B. Child, Jason L. Blum   +2 more
doaj   +1 more source

Diversifying endpoints in biodegradation testing of microplastics

Environmental Sciences Europe
To counteract microplastic (MP) pollution the European Commission adopted a restriction of intentionally adding synthetic polymer microparticles to products, such as detergents, rinse-off cosmetics, controlled-release fertilizers or pesticides.
Eva-Maria Teggers, Jonas Hardebusch, Boris Meisterjahn, Markus Simon, Dieter Hennecke, Roman Heumann, Holger Egger, Philipp Dalkmann, Andreas Schäffer, Annika Jahnke   +9 more
doaj   +1 more source

Considerations and Challenges for Acute Inhalation Toxicity Testing and Classification of Zinc Sulphide Under REACH

Toxics
Zinc sulphide is a widely used inorganic powder, and its production has reached quantities greater than 1000 t/year. Therefore, in accordance with OECD guideline 436, an acute inhalation test was implemented to provide more accurate data.
Gustav Gerd Bruer, Noömi Lombaert, Arne Burzlaff, Christine Spirlet, Daria Gödecke, Mehmet Ramazanoglu, Otto Creutzenberg   +6 more
doaj   +1 more source

Safety evaluation of ethanol extract from Artocarpus altilis leaves as a herbal medicine candidate: Studies in acute and subchronic toxicity

Phytomedicine Plus
Background: Artocarpus altilis is a traditional medicine proven to be efficacious in several pharmacological tests using animal models. However, there have been no reports regarding its safety so far.
Fitrya Fitrya, Elfita Elfita, Ferlinahayati, Salma Fayzah Septami, Umi Tsalsa Sabrina, Fatma Sri Wahyuni, Annisa Amriani, Rennie Puspa Novita   +7 more
doaj   +1 more source

A Review On Updates To OECD Guidelines On The Testing Of Chemicals

The OECD Guidelines for the Testing of Chemicals (TGs) are regularly reviewed in light of evolving assessment techniques, scientific advancements, and animal welfare issues. The TG 451 update has conducted concurrently with the Test Guidelines 452, Chronic Toxicity Studies (TG 452), and 453, Studies of combined chronic toxicity/carcinogenicity, with ...
openaire   +1 more source

Toxicity evaluation of metsulfuron-methyl, nicosulfuron, and methoxyfenozide as pesticides in Indonesia

Open Agriculture
Pesticides are substances widely used to control or eliminate pests, including weeds, insects, and other harmful organisms. Agricultural pesticides, in particular, must meet specific safety and quality standards before being marketed.
Natawigena Wahyu Daradjat, Rifasta Muhammad Ilfadry, Susanto Agus, Wilar Gofarana, Suhandi Cecep   +4 more
doaj   +1 more source

Advancing Endocrine Disruptors via In Vitro Evaluation: Recognizing the Significance of the Organization for Economic Co-Operation and Development and United States Environmental Protection Agency Guidelines, Embracing New Assessment Methods, and the Urgent Need for a Comprehensive Battery of Tests

Toxics
Efforts are being made globally to improve the evaluation and understanding of endocrine-disrupting chemicals. Recognition of their impact on human health and the environment has stimulated attention and research in this field.
Sophie Fouyet, Marie-Caroline Ferger, Pascale Leproux, Patrice Rat, Mélody Dutot   +4 more
doaj   +1 more source

Graphene-Based Materials are Not Skin Sensitizers: Adoption of the in Chemico/In Vitro OECD Test Guidelines

Nanoscale
Graphene-based materials skin sensitization property was evaluated through the adoptable OECD test guidelines: OECD TG 442D and E indicate that they are not skin sensitizers. Image created in BioRender. Pelin, M.
Michela Carlin, Marc Morant-Giner, Marina Garrido, Silvio Sosa, Alberto Bianco, Aurelia Tubaro, Maurizio Prato, Marco Pelin   +7 more
openaire   +6 more sources

A Statistical Approach for Comparative Assessment of the Effect of Smoke Exposure in In Vivo Experiments: A Case Study of an OECD 90-Day Inhalation Study Including 3R4F and 1R6F Reference Cigarettes

Contributions to Tobacco and Nicotine Research
In vivo testing is a crucial part of product development. Most in vivo toxicology studies are conducted in a heavily regulated environment, in accordance with sound scientific principles, and in an ethical manner.
Kondylis Athanasios, Kogel Ulrike, Ho Jenny, Wong EeTsin, Phillips Blaine, Hoeng Julia, Vanscheeuwijck Patrick   +6 more
doaj   +1 more source