Results 41 to 50 of about 18,586 (163)

Current status and future challenges of genotoxicity OECD Test Guidelines for nanomaterials: a workshop report. [PDF]

Mutagenesis, 2023
Doak SH, Andreoli C, Burgum MJ, Chaudhry Q, Bleeker EAJ, Bossa C, Domenech J, Drobne D, Fessard V, Jeliazkova N, Longhin E, Rundén-Pran E, Stępnik M, El Yamani N, Catalán J, Dusinska M.   +15 more
europepmc   +1 more source

Using irAOP for non-clinical safety evaluation of biotechnology-derived pharmaceuticals and ATMPs: a paradigm shift into a systematic and holistic framework

Journal of Immunotoxicology
The chances and opportunities in modern biology inspired devising new therapeutics are mind blowing. The promises reach from successfully treating so-far incurable diseases like cancer and certain infections, to modulating and fine tuning the immune ...
Armin Braun, Susann Dehmel
doaj   +1 more source

Simulation of mouse and rat spermatogenesis to inform genotoxicity testing using OECD test guideline 488

Mutation Research/Genetic Toxicology and Environmental Mutagenesis, 2018
The Organisation for Economic Co-operation and Development Test Guideline (TG) 488 for the transgenic rodent (TGR) mutation assay recommends two sampling times for assessing germ cell mutagenicity following the required 28-day exposure period: 28 + > 49 days for mouse sperm and 28 + >70 days for rat sperm from the cauda epididymis, or three days (i.e.,
Francesco Marchetti, Marilyn Aardema, Carol Beevers, Jan van Benthem, George R. Douglas, Roger Godschalk, Carole L. Yauk, Robert Young, Andrew Williams   +8 more
openaire   +5 more sources

Genotoxicity evaluation of alpha-linolenic acid-diacylglycerol oil

Toxicology Reports, 2016
The alpha-linolenic acid (ALA)-diacylglycerol (DAG) oil is an edible oil enriched with DAG (>80%) and ALA (>50%). Although DAG oil, which mainly consists of oleic and linoleic acids has no genotoxic concerns, the fatty acid composition could affect the ...
Hiroshi Honda, Yurika Fujita, Aya Hayashi, Naohiro Ikeda, Yuichi Ito, Osamu Morita   +5 more
doaj   +1 more source

Undetactable levels of genotoxicity of SiO2 nanoparticles in in vitro and in vivo tests

International Journal of Nanomedicine, 2014
Jee Young Kwon,1,* Hye Lim Kim,1,* Jong Yun Lee,2 Yo Han Ju,2 Ji Soo Kim,2 Seung Hun Kang,1 Yu-Ri Kim,3 Jong-Kwon Lee,4 Jayoung Jeong,4 Meyoung-Kon Kim,3 Eun Ho Maeng,2 Young Rok Seo1 1Department of Life Science, Institute of Environmental Medicine ...
Kwon JY, Kim HL, Lee JY, Ju YH, Kim JS, Kang SH, Kim YR, Lee JK, Jeong J, Kim MK, Maeng EH, Seo YR   +11 more
doaj  

A toxicity profile of the Pheroid® technology in rodents

Toxicology Reports, 2019
The Pheroid® drug delivery system is now on the threshold of progressing into human clinical trials for various patented pharmaceutical applications and a systematic investigation of its toxicological properties in vitro and in vivo is thus a priority ...
Janke Kleynhans, Dale Elgar, Thomas Ebenhan, Jan Rijn Zeevaart, Awie Kotzé, Anne Grobler   +5 more
doaj   +1 more source

Oral toxicity of small microplastic of polyamide assessed by a standardized guideline study

Microplastics and Nanoplastics
There is a dire lack of standardized in vivo studies investigating the human hazard by microplastics by OECD test guidelines. The lack of suitable test materials contributes to this situation.
Roland Buesen, Stefanie Vogel, Tizia Thoma, Volker Strauss, Sibylle Gröters, Kathrin Becker, Frank Müller, Till Gründling, Patrizia Pfohl, Amelie Vogel, Andrea Haase, Wendel Wohlleben   +11 more
doaj   +1 more source

Effect Of Environmental Load On The Toxicity Of Bottom Sediments

Nova Biotechnologica et Chimica, 2015
This study is devoted to Ecotoxicity tests, Terrestrial Plant Test (modification of OECD 208), Phytotoxkit microbiotest on Sinapis alba and chronic tests of Earthworm (Eisenia veneta), modification of OECD Guidelines for the testing of chemicals 317 ...
Šestinová Oľga, Findoráková Lenka, Dolinská Silvia, Hančuľák Jozef, Špaldon Tomislav, Fedorová Erika   +5 more
doaj   +1 more source

A new OECD test guideline for the predatory soil mite Hypoaspis aculeifer: Results of an international ring test

Ecotoxicology and Environmental Safety, 2012
Predatory mites are considered important biological indicators to assess potential effects of plant protection products. Toxicity testing of terrestrial mite species is required for authorisation of plant protection products in the European Union in cases where testing of leaf dwelling mites is not relevant, i.e.
Smit, CE, Moser, Th, Roembke, J
openaire   +3 more sources

Experimental data from the development of Lymnaea stagnalis embryo test for chemicals hazard assessment

Data in Brief
This study aimed to contribute to the development of an embryo-test using the gastropod Lymnaea stagnalis, identified by the Organization for Economic Co-operation and Development (OECD) as a potential invertebrate test animal model.
Ricardo Capela, Luís Filipe Castro, Miguel Machado Santos, Jeanne Garric   +3 more
doaj   +1 more source