Results 21 to 30 of about 18,586 (163)

Toxicological Screening of Four Bioactive Citroflavonoids: In Vitro, In Vivo, and In Silico Approaches

Molecules, 2020
Many studies describe different pharmacological effects of flavonoids on experimental animals and humans. Nevertheless, few ones are confirming the safety of these compounds for therapeutic purposes. This study aimed to investigate the preclinical safety
Rolffy Ortiz-Andrade, Jesús Alfredo Araujo-León, Amanda Sánchez-Recillas, Gabriel Navarrete-Vazquez, Avel Adolfo González-Sánchez, Sergio Hidalgo-Figueroa, Ángel Josabad Alonso-Castro, Irma Aranda-González, Emanuel Hernández-Núñez, Tania Isolina Coral-Martínez, Juan Carlos Sánchez-Salgado, Victor Yáñez-Pérez, M. A. Lucio-Garcia   +12 more
doaj   +1 more source

The Status of OECD guidelines regarding regulatory compliance of 2D materials: a case study of graphene

Mundo Nano
The regulatory testing of graphene and other two-dimensional (2D) materials presents significant challenges due to the unique physicochemical properties of these materials.
Blanca Suarez-Merino, Luis Mauricio Ortiz Galvez   +1 more
doaj   +1 more source

Updating of OECD Guidelines for the Testing of Chemicals

Water Science and Technology, 1992
OECD's activity for the safety evaluation of chemicals is presented with its purpose and strategy. The Updating of OECD guidelines for the ecotoxicological effect assessment is discussed in detail. OECD's approach for ecotoxicological effect assessment is also discussed.
openaire   +1 more source

Technical challenges of testing polymer materials in OECD test guideline methods addressing effects on human health, biotic systems and analytics

NAM Journal
Polymers are substances composed of molecules containing repeating monomer units and exhibiting a distribution of molecular weights due to differences in chain length.
Susanne N. Kolle, Friederike Lünne, Denis Botin, Nora Melchin, Naveed Honarvar, Simon Lüderwald, Dorothee Funk-Weyer, David Schaffert, Robert Landsiedel   +8 more
doaj   +1 more source

In vitro Alternatives to Acute Inhalation Toxicity Studies in Animal Models—A Perspective

Frontiers in Bioengineering and Biotechnology, 2020
When assessing the risk and hazard of a non-pharmaceutical compound, the first step is determining acute toxicity, including toxicity following inhalation.
Dania Movia, Solene Bruni-Favier, Adriele Prina-Mello, Adriele Prina-Mello   +3 more
doaj   +1 more source

In vitro genotoxicity testing strategy for nanomaterials and the adaptation of current OECD guidelines

Mutation Research/Genetic Toxicology and Environmental Mutagenesis, 2012
There is a pressing requirement to define a hazard identification and risk management strategy for nanomaterials due to the rapid growth in the nanotechnology industry and their promise of life-style revolutions through the development of wide-ranging nano-containing consumer products.
Doak, S.H., Manshian, Bella, Jenkins, G.JS., Singh, N.   +3 more
openaire   +5 more sources

Testing the Aquatic Toxicity of 2D Few-Layer Graphene Inks Using Rainbow Trout (Oncorhynchus mykiss): In Vivo and In Vitro Approaches to Support an SSbD Assessment

Toxics
Graphene-based conductive inks offer attractive possibilities in many printing technology applications. Often, these inks contain a mixture of compounds, such as solvents and stabilizers. For the safe(r) and sustainable use of such materials in products,
Gregorio Molés, Mona Connolly, Ana Valdehita, Gerardo Pulido-Reyes, Maria L. Fernandez-Cruz, Emmanuel Flahaut, José M. Navas   +6 more
doaj   +1 more source

In vivo Genotoxicity of Silver Nanoparticles after 90-day Silver Nanoparticle Inhalation Exposure

Safety and Health at Work, 2011
Objectives: The antimicrobial activity of silver nanoparticles has resulted in their widespread use in many consumer products. Yet, despite their many advantages, it is also important to determine whether silver nanoparticles may represent a hazard to ...
Jin Sik Kim, Jae Hyuck Sung, Jun Ho Ji, Kyung Seuk Song, Ji Hyun Lee, Chang Soo Kang, Il Je Yu   +6 more
doaj   +1 more source

In vitro endocrine-disrupting effects of Enniatins and Beauvericin: assessment of estrogen and androgen receptor transcriptional activities and gene expression of enzymes of the steroid synthesis pathway

Emerging Contaminants
Mycotoxins Enniatins (ENNs) and Beauvericin (BEA) are emerging contaminants of concern due to increasing occurrence in cereals, because of climate change favouring their production by fungi.
Irene Masciola, Anastasia Repouskou, Mylène Lorcin, Alexandra Nestora, Anastasia Spyropoulou, Ioannis Theologidis, Sabrina Tait, Laurent Gaté   +7 more
doaj   +1 more source

The OECD’s micronucleus test guideline for single exposure to an agent and the genotox-kinetic alternative [PDF]

Mutagenesis, 2017
The 'Organization for Economic Co-operation and Development (OECD) guidelines for the Testing of Chemicals' aims to identify whether a chemical is a genotoxic hazard, and these guidelines 'are periodically reviewed in the light of scientific progress, changing regulatory needs and animal welfare considerations'.
Pedro, Morales-Ramírez, Teresita, Vallarino-Kelly, Virginia Leticia, Cruz-Vallejo   +2 more
openaire   +2 more sources