Results 11 to 20 of about 18,586 (163)

Aqueous extract from Chrysophyllum cainito bark exhibits embryonic toxicity in Danio rerio and negligible acute toxicity in adult wistar rats [PDF]

Archives of Biological Sciences, 2021
Chrysophyllum cainito has been used as a traditional medicine to treat a wide range of diseases, but the toxicity profile of this plant remains unknown. This study aimed to evaluate the acute toxicity of the aqueous extract of C.
Doan Hau Van, Sritangos Pishyaporn, Weeranantanapan Oratai, Chudapongse Nuannoi   +3 more
doaj   +1 more source

Biodegradability and ecotoxicity of bio-insulating oils in aqueous and soil environments in Douala, Cameroon

Scientific African, 2022
This work focuses on the analysis of the deleterious effects in case of spills in aqueous and soil environments of palm kernel oil methyl esters (PKOME) and castor oil methyl esters (COME) prototyped to substitute mineral oils in power transformers.
G. Mengata Mengounou, A. Moukengue Imano, O.T. Sosso Mayi, Y.Y. Abomo Beyeme, C.F. Bekele Massako, E. Tchamdjio Nkouetcha   +5 more
doaj   +1 more source

Toward a Better Testing Paradigm for Developmental Neurotoxicity: OECD Efforts and Regulatory Considerations

Biology, 2021
Characterization of potential chemical-induced developmental neurotoxicity (DNT) hazard is considered for risk assessment purposes by many regulatory sectors.
Magdalini Sachana, Timothy J. Shafer, Andrea Terron   +2 more
doaj   +1 more source

Guidance on the assessment of pesticide residues in rotational crops

EFSA Journal, 2023
EFSA has prepared a guidance document on the assessment of studies on the nature and magnitude of pesticide residues in rotational crop studies as defined in Section 6.6 of the Annex to Regulation (EU) No 283/2013.
European Food Safety Authority (EFSA), Luna Greco, Judit Janossy, Samira Jarrah, Aija Kazocina, José Oriol Magrans, Hermine Reich   +6 more
doaj   +1 more source

Assessment of acute and sub-chronic neurotoxicity of Morus alba L. fruits in rodents

Future Journal of Pharmaceutical Sciences, 2020
Background Morus alba L. fruits are consumed since long for their nutritional and medicinal values. Although there were studies on the neuroprotective activity of the fruit extract, safety profile of the fruit extract is not yet explored as per the ...
Arpita Paul, Anshul Shakya, Md Kamaruz Zaman   +2 more
doaj   +1 more source

In vitro genotoxicity studies: n-Butyl acrylate L5178Y mouse lymphoma (TK+/− locus assay), 2-Ethylhexyl acrylate gene mutation assay in Chinese hamster V79 cells, and 2-Ethylhexyl acrylate micronucleus test in human lymphocytes

Data in Brief, 2018
Available point mutation tests have shown inconsistent results with various acrylates. Most of those tests were performed prior to OECD guidelines and appropriate data regarding cytotoxicity are not given. Data from three current OECD guideline compliant
Sandra Murphy, Robert Ellis-Hutchings, Lavorgie Finch, Stefanie Welz, Karin Wiench   +4 more
doaj   +1 more source

Data collection on the use of embryo bioassays with aquatic animals for toxicity testing and hazard assessment of emerging pollutants

Data in Brief, 2020
A thorough bibliographic survey on the use of embryo-tests with aquatic animals for toxicity testing was performed. The data regarding to the compounds sensitivity (NOEC, LOEC, EC50 and LC50), the available resources for the different animal models ...
Ricardo Capela, Jeanne Garric, Luís Filipe Costa Castro, Miguel Machado Santos   +3 more
doaj   +1 more source

Nanopharmaceuticals (Au-NPs) after use: Experiences with a complex higher tier test design simulating environmental fate and effect

Ecotoxicology and Environmental Safety, 2021
The current environmental hazard assessment is based on the testing of the pristine substance. However, it cannot be excluded that (nano)pharmaceuticals are excreted into sewage during the use phase followed by entry into wastewater treatment plants ...
Kerstin Hund-Rinke, Cecilia Diaz, Anne Jurack, Judith Klein, Burkhard Knopf, Karsten Schlich, María Luisa Fernández-Cruz, David Hernández-Moreno, Nicolas Manier, Pascal Pandard, Susana I.L. Gomes, Bruno Guimarães, Janeck J. Scott-Fordsmand, Mónica J.B. Amorim   +13 more
doaj   +1 more source

Acute and Repeated Dose 28-Day Oral Toxicity Study of the Aqueous Extracts from the Leafy Stem and Fruit of Pedalium murex D.Royen EX.L in Wistar Rats

Journal of Toxicology, 2023
Background. Pedalium murex (P. murex) is used in folk medicine for treatment of male infertility. However, scientific data on its safety are limited. Objective.
Gérard Bessan Dossou-Agoin, Maxime Machioud Sangaré-Oumar, Téniola Isabelle Sacramento, Mariette Sindété, Egnon Jacques Hougbénou-Houngla, Nounagnon Darius Tossavi, Simon Azonbakin, Adam Gbankoto   +7 more
doaj   +1 more source

Setting off on the right path: make your research regulatory relevant

Frontiers in Research Metrics and Analytics
Scientifically well-established methods do not automatically get used in regulations. Even when there is an urgent need for regulatory relevant test methods, methods need to pass through a so-called standardization process.
Anna Pohl, Elise Morel, Elise Morel, Eric A. J. Bleeker, Sean Kelly, Rachel Smith, Claus Svendsen, Thomas A. J. Kuhlbusch, Thomas A. J. Kuhlbusch, Thomas A. J. Kuhlbusch, Elisabeth Heunisch   +10 more
doaj   +1 more source