Results 91 to 100 of about 287 (117)

Genotoxicity and cytotoxicity evaluation of oenothein B and its protective effect against mitomycin C-induced mutagenic action

Mutation Research/Genetic Toxicology and Environmental Mutagenesis, 2014
The natural product oenothein B (OeB), a dimeric macrocyclic ellagitannin, has a wide range of biological activities, such as antioxidant, anti-inflammatory, anti-viral, antifungal, and antitumor. However, investigations concerning its genotoxicity have not been carried out.
Cinthia Aparecida, Silva, Carolina Ribeiro, Silva, Jefferson Hollanda, Véras, Lee, Chen-Chen, Pedro Henrique, Ferri, Suzana da Costa, Santos   +5 more
openaire   +4 more sources

Induction of neutral endopeptidase activity in PC-3 cells by an aqueous extract of Epilobium angustifolium L. and oenothein B

Phytomedicine, 2006
An aqueous extract of Epilobium angustifolium and its main compound oenothein B (OeB), a dimeric macrocyclic ellagitannin, are specifically able to induce the neutral endopeptidase (NEP) in prostate cancer cells. The angiotensin-converting enzyme (ACE) is not influenced.
A, Kiss, J, Kowalski, M F, Melzig
openaire   +4 more sources

Inhibition of 5α-Reductase and Aromatase by the Ellagitannins Oenothein A and Oenothein B fromEpilobiumSpecies

Planta Medica, 1997
Species of the genus Epilobium (Onagraceae) have been investigated for their activity against 5 alpha-reductase and aromatase, two enzymes which are involved in the aetiology of benign prostatic hyperplasia (BPH). Activity-guided fractionation has led to the identification of two macrocyclic ellagitannins, oenothein A (1) and oenothein B (2), as the ...
B, Ducrey, A, Marston, S, Göhring, R W, Hartmann, K, Hostettmann   +4 more
openaire   +2 more sources

Oenothein B, dimeric hydrolysable tannin inhibiting HCV invasion from Oenothera erythrosepala

Journal of Natural Medicines, 2018
The envelope proteins of the hepatitis C virus (HCV), E1 and E2, have been revealed to be essential for invasion of HCV. Thus, we were engaged in the search for the inhibitors against HCV invasion through the assay system using the model virus expressing recombinant HCV envelopes, E1 and E2. Now, we disclosed dimeric hydrolysable tannin oenothein B (1)
Satoru Tamura, Gang-Ming Yang, Teruaki Koitabashi, Yoshiharu Matsuura, Yasumasa Komoda, Tomikazu Kawano, Nobutoshi Murakami   +6 more
openaire   +2 more sources

Stimulation and priming of innate lymphocytes by oenothein B (89.59)

The Journal of Immunology, 2010
Abstract Oenothein B is an immunomodulatory tannin isolated from the Epilobium angustifolium plant. This compound is known to affect myeloid cells and these effects include enhanced chemotaxis, NF-κB activation, and production of proinflammatory cytokines, including TNFα and IL-6.
Andrew Ramstead, Igor Schepetkin, Mark Quinn, Mark Jutila   +3 more
openaire   +1 more source

Regulatory Effect and Mechanism of Oenothein B in Reducing Fat Accumulation in Caenorhabditis Elegans

European Journal of Lipid Science and Technology, 2023
AbstractOenothein B (OEB) displays various biological activities, including immunomodulatory, antioxidant, and anticancer effects. However, the underlying mechanisms remain unclear. Therefore, in this study, the effect of OEB isolated from Eucalyptus leaves on fat deposition and its underlying mechanism are explored in Caenorhabditis elegans （C.elegans)
Xiaoying Zhang, Qiaoxing Liu, Yun Chen, Wei Li, Konglong Feng, Jie Xiao, Yong Cao, Zuanxian Su, Guang Wang, Yunjiao Chen   +9 more
openaire   +1 more source

[Oenothein B inhibits proliferation and migration of breast cancer cells by regulating P53].

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 2023
The effects of oenothein B(OEB) on the proliferation, apoptosis, invasion, and migration of breast cancer MCF-7 and MDA-MB-231 cells were investigated by cell culture in vitro, network pharmacology, and molecular docking. In vitro cell experiments revealed that OEB inhibited the proliferation and colony formation ability, and promoted the apoptosis and
Mao-Hong, Luo, Ya, He, Hong, Li, Teng-Xiang, Chen, Shan, Lei, Jin-Juan, Zhang, Lu, Wang   +6 more
openaire   +1 more source

Age influences the lymphocyte response to the ellagitannin oenothein B and acai polysaccharides. (VET2P.1040)

The Journal of Immunology, 2014
Abstract The effects of nutritional supplements on immunity are still not well understood. For example, although aging affects immune cell responsiveness, it is not well known if immune stimulation by some nutritional supplements is also affected by aging.
Andrew Ramstead, Igor Schepetkin, Mark Quinn, Mark Jutila   +3 more
openaire   +1 more source

Oenothein B boosts antioxidant capacity and supports metabolic pathways that regulate antioxidant defense inCaenorhabditis elegans

Food & Function, 2020
This study provides new insights into the effects of OEB treatment on antioxidant capacity and metabolism that suggest that OEB could be used as a good source of natural antioxidants.
Wei Li, Ziyin Li, Ming-Jun Peng, Xiaoying Zhang, Yunjiao Chen, Yu-Yu Yang, Xiao-Xiang Zhai, Guo Liu, Yong Cao   +8 more
openaire   +2 more sources

Oenothein B inhibits the expression ofPbFKS1transcript and induces morphological changes inParacoccidioides brasiliensis

Medical Mycology, 2007
The fungus Paracoccidioides brasiliensis is the causative agent of paracoccidioidomycosis (PCM), the most prevalent human systemic mycosis in Latin America. Drug toxicity and the appearance of resistant strains have created the need to search for new therapeutic approaches.
Glaciane D, Santos, Pedro H, Ferri, Suzana C, Santos, Sônia N, Bao, Célia M A, Soares, Maristela, Pereira   +5 more
openaire   +2 more sources