Results 141 to 150 of about 14,685,807 (300)
〈PAPERS and REPORTS〉Chemical Modification of siRNA Eliminating Off-target Effect by the Sense Strand [PDF]
For clinical applications of small interfering RNA (siRNA), chemical structure of siRNA should be optimized to be taken up into cells effectively, be resistant against nuclease digestion, be loaded onto RNA induced silencing complex (RISC) rapidly and ...
塩浜, 康雄 +11 more
core +1 more source
Biophysical approaches for studying viral entry
FEBS Letters, EarlyView.Viruses infect all living organisms and have been responsible for major epidemics and pandemics. Their ongoing evolutionary battle with host defenses creates a constant need for improved tools to study viral behavior. Advancing methods to probe viral attachment, fusion, and genome release deepen our understanding of how infections begin and support the
Inbar Yosibash, Raya Sorkin
wiley +1 more source
A Potential Off-Target Effect of the Wnt/β-Catenin Inhibitor KYA1797K: PD-L1 Binding and Checkpoint Inhibition. [PDF]
Biomed Hub, 2023 Thuru X, Magnez R, Vergoten G, Bailly C.
europepmc +1 more source
The human gut microbiome across the life course
FEBS Letters, EarlyView.Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero +4 more
wiley +1 more source
Off-Target Effect of Activation of NF-κB by HIV Latency Reversal Agents on Transposable Elements Expression. [PDF]
Viruses, 2022 Curty G +4 more
europepmc +1 more source
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
Dual-gRNA approach with limited off-target effect corrects C9ORF72 repeat expansion in vivo. [PDF]
Sci Rep, 2022 Piao X +5 more
europepmc +1 more source
FEBS Letters, EarlyView.We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace +6 more
wiley +1 more source
FEBS Letters, EarlyView.Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley +1 more source
Mechanistic mathematical modeling of abscopal effect reveals mechanisms of off-target tumor response
Frontiers in ImmunologyIntroductionLocal radiotherapy rarely triggers regression of distant, non-irradiated tumors (the “abscopal” effect), but this outcome is unpredictable because it depends on interacting processes, such as antigen release, antigen presentation, T-cell ...
Andreas G. Hadjigeorgiou +5 more
doaj +1 more source