Results 251 to 260 of about 2,759,679 (292)
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Nature Chemical Biology, 2017
The 'off-targets' of a drug are often poorly characterized yet could be harnessed in the treatment of complex diseases. A recent study used a small-molecule screening in non-small-cell lung cancer to repurpose an FDA-approved ALK/IGF1R inhibitor and uncover its mechanism of action.
Gaye Saginc +2 more
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The 'off-targets' of a drug are often poorly characterized yet could be harnessed in the treatment of complex diseases. A recent study used a small-molecule screening in non-small-cell lung cancer to repurpose an FDA-approved ALK/IGF1R inhibitor and uncover its mechanism of action.
Gaye Saginc +2 more
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Off-target effects and the solution
Nature Plants, 2019Adenine base editors (ABEs) and cytosine base editors (CBEs) are powerful tools for targeted base conversions, but their editing specificities are largely unknown. Now, two reports demonstrate that ABEs are highly specific, but BE3-type CBEs tend to generate genome-wide off-target single nucleotide variations.
Jintao, Tang +2 more
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Immunological off-target effects of imatinib
Nature Reviews Clinical Oncology, 2016Around 15 years ago, imatinib mesylate (Gleevec(®) or Glivec(®), Novartis, Switzerland) became the very first 'targeted' anticancer drug to be clinically approved. This drug constitutes the quintessential example of a successful precision medicine that has truly changed the fate of patients with Philadelphia-chromosome-positive chronic myeloid ...
Laurence Zitvogel +4 more
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Designing effective siRNAs with off-target control
Biochemical and Biophysical Research Communications, 2004Successful gene silencing by RNA interference requires a potent and specific depletion of the target mRNA. Target candidates must be chosen so that their corresponding short interfering RNAs are likely to be effective against that target and unlikely to accidentally silence other transcripts due to sequence similarity.
Ola, Snøve +6 more
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The Off-Target Effects of Torcetrapib
Endocrinology, 2009Cholesterol ester transfer protein (CETP) is responsible for the transfer of lipid from high-density lipoprotein (HDL; so-called good cholesterol) to low-density lipoprotein (LDL; socalled bad cholesterol). From a number of epidemiological studies, there is wide assent that subjects with high HDL are relatively protected in terms of cardiovascular risk,
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siRNA Design Principles and Off-Target Effects
2013Short interfering RNAs (siRNAs) are a major research tool that allows for knock-down of target genes via selective mRNA destruction in almost all eukaryotic organisms. siRNAs typically consist of a synthetic ∼21 nucleotide (nt) RNA-duplex where one strand is designed with perfect complementarity to the target mRNA.
Sebastian, Petri, Gunter, Meister
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Science Signaling, 2016
A drug developed to inhibit receptor tyrosine kinases also binds to an E3 ubiquitin ligase to promote the degradation of β-catenin.
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A drug developed to inhibit receptor tyrosine kinases also binds to an E3 ubiquitin ligase to promote the degradation of β-catenin.
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Acute off-target effects of neural circuit manipulations
Nature, 2015Rapid and reversible manipulations of neural activity in behaving animals are transforming our understanding of brain function. An important assumption underlying much of this work is that evoked behavioural changes reflect the function of the manipulated circuits.
Timothy M, Otchy +7 more
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DIRECT ROUTES TO OFF-TARGET EFFECTS
Chemical & Engineering News Archive, 2011RESEARCHERS HAVE devised the first techniques that directly assess “off-target effects” of gene-cutting zinc finger nucleases (ZFNs). The work could lead to ZFNs that more precisely target specific genes for use in gene therapy or as research tools.
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