Results 261 to 270 of about 13,860,386 (295)
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Science Signaling, 2016
A drug developed to inhibit receptor tyrosine kinases also binds to an E3 ubiquitin ligase to promote the degradation of β-catenin.
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A drug developed to inhibit receptor tyrosine kinases also binds to an E3 ubiquitin ligase to promote the degradation of β-catenin.
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siRNA Design Principles and Off-Target Effects
2013Short interfering RNAs (siRNAs) are a major research tool that allows for knock-down of target genes via selective mRNA destruction in almost all eukaryotic organisms. siRNAs typically consist of a synthetic ∼21 nucleotide (nt) RNA-duplex where one strand is designed with perfect complementarity to the target mRNA.
Sebastian, Petri, Gunter, Meister
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SGLT2 inhibitors, sodium and off-target effects: an overview
Journal of Nephrology, 2020Sodium-glucose cotransporter 2 inhibitors (SGLT2i) are a relatively new class of antidiabetic drugs that in addition to emerging as an effective antihyperglycemic treatment have been shown to improve, in several trials, both renal and cardiovascular outcomes.
De Pascalis A. +4 more
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Acute off-target effects of neural circuit manipulations
Nature, 2015Rapid and reversible manipulations of neural activity in behaving animals are transforming our understanding of brain function. An important assumption underlying much of this work is that evoked behavioural changes reflect the function of the manipulated circuits.
Timothy M, Otchy +7 more
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DIRECT ROUTES TO OFF-TARGET EFFECTS
Chemical & Engineering News Archive, 2011RESEARCHERS HAVE devised the first techniques that directly assess “off-target effects” of gene-cutting zinc finger nucleases (ZFNs). The work could lead to ZFNs that more precisely target specific genes for use in gene therapy or as research tools.
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Designing Functional siRNA with Reduced Off-Target Effects
2012RNA interference (RNAi) mediated by small interfering RNA (siRNA) is now widely used to knock down gene expression in a sequence-specific manner, making it a powerful tool not only for studying gene functions but also for therapeutic applications. siRNA decreases the expression level of the intended target gene with complete complementarity by cleaving
Yuki, Naito, Kumiko, Ui-Tei
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Off-Target Effects of a Defense of Denial
The American Journal of Bioethics, 2018Mary Anderlik, Majumder +1 more
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Methods for detecting off-target effects of CRISPR/Cas9
Biotechnology AdvancesThe CRISPR/Cas9 system has emerged as a revolutionary tool for gene editing, widely used in the biomedical field due to its simplicity, efficiency, and cost-effectiveness. However, evidence suggests that CRISPR/Cas9 can induce off-target effects, leading to unintended mutations that may compromise the precision of gene modifications.
Ying-Ying, Xu +6 more
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Improving target assessment in biomedical research: the GOT-IT recommendations
Nature Reviews Drug Discovery, 2020Björn Gerlach +2 more
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