Results 251 to 260 of about 13,860,386 (295)

From rules to foundation models: a comprehensive review of machine learning approaches for siRNA design. [PDF]

NAR Genom Bioinform
Khodagholi Z, Yousefi N.
europepmc   +1 more source

Canon enables causal inference of downstream genes in single-cell CRISPR studies via instrumental variable analysis. [PDF]

Proc Natl Acad Sci U S A
Wu P, Zhou X.
europepmc   +1 more source

Off site, in tune, on target

, 1994
Alfrey, H., Parsons, C.
core  

The Off-Target Effects of Oseltamivir on Influenza

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Off-target effects and the solution

Nature Plants, 2019
Adenine base editors (ABEs) and cytosine base editors (CBEs) are powerful tools for targeted base conversions, but their editing specificities are largely unknown. Now, two reports demonstrate that ABEs are highly specific, but BE3-type CBEs tend to generate genome-wide off-target single nucleotide variations.
Jintao, Tang, Letian, Chen, Yao-Guang, Liu   +2 more
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Immunological off-target effects of imatinib

Nature Reviews Clinical Oncology, 2016
Around 15 years ago, imatinib mesylate (Gleevec(®) or Glivec(®), Novartis, Switzerland) became the very first 'targeted' anticancer drug to be clinically approved. This drug constitutes the quintessential example of a successful precision medicine that has truly changed the fate of patients with Philadelphia-chromosome-positive chronic myeloid ...
Laurence Zitvogel, Sylvie Rusakiewicz, Bertrand Routy, Maha Ayyoub, Guido Kroemer   +4 more
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Harnessing off-target effects

Nature Chemical Biology, 2017
The 'off-targets' of a drug are often poorly characterized yet could be harnessed in the treatment of complex diseases. A recent study used a small-molecule screening in non-small-cell lung cancer to repurpose an FDA-approved ALK/IGF1R inhibitor and uncover its mechanism of action.
Gaye Saginc, Franziska Voellmy, Rune Linding   +2 more
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The Off-Target Effects of Torcetrapib

Endocrinology, 2009
Cholesterol ester transfer protein (CETP) is responsible for the transfer of lipid from high-density lipoprotein (HDL; so-called good cholesterol) to low-density lipoprotein (LDL; socalled bad cholesterol). From a number of epidemiological studies, there is wide assent that subjects with high HDL are relatively protected in terms of cardiovascular risk,
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Designing effective siRNAs with off-target control

Biochemical and Biophysical Research Communications, 2004
Successful gene silencing by RNA interference requires a potent and specific depletion of the target mRNA. Target candidates must be chosen so that their corresponding short interfering RNAs are likely to be effective against that target and unlikely to accidentally silence other transcripts due to sequence similarity.
Ola, Snøve, Magnar, Nedland, Ståle H, Fjeldstad, Håkon, Humberset, Olaf R, Birkeland, Thomas, Grünfeld, Pål, Saetrom   +6 more
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Caveat of RNAi in Plants: The Off-Target Effect

2011
RNA interference (RNAi), mediated by short interfering RNAs (siRNAs), is one of the widely used functional genomics method for suppressing the gene expression in plants. Initially, gene silencing by RNAi mechanism was believed to be specific requiring sequence homology between siRNA and target mRNA.
Muthappa, Senthil-Kumar, Kirankumar S, Mysore   +1 more
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