Results 261 to 270 of about 2,759,679 (292)
Some of the next articles are maybe not open access.
Designing Functional siRNA with Reduced Off-Target Effects
2012RNA interference (RNAi) mediated by small interfering RNA (siRNA) is now widely used to knock down gene expression in a sequence-specific manner, making it a powerful tool not only for studying gene functions but also for therapeutic applications. siRNA decreases the expression level of the intended target gene with complete complementarity by cleaving
Yuki, Naito, Kumiko, Ui-Tei
openaire +2 more sources
TAG-RNAi overcomes off-target effects in cancer models
Oncogene, 2019RNA interference offers therapeutic opportunities for the clinical targeting of otherwise undruggable oncogenes. However RNAi can have off-target effects that considerably increase treatment risks. To manage these side effects and allow an easy subtraction of their activity in healthy tissues, we present here the TAG-RNAi approach where cells that are ...
Julien Champagne +9 more
openaire +2 more sources
Selective Therapeutic Intervention: A Challenge against Off-Target Effects
Trends in Molecular Medicine, 2017Despite the massive global spend on biology-driven drug discovery, tackling the issue of side effects and adverse events resulting from drug promiscuity represents a persistent challenge. Although delivering authentic medical innovations today is more complex than ever, minimization of off-target effects should be a priority.
Filip Rázga, Veronika Némethová
openaire +2 more sources
Caveat of RNAi in Plants: The Off-Target Effect
2011RNA interference (RNAi), mediated by short interfering RNAs (siRNAs), is one of the widely used functional genomics method for suppressing the gene expression in plants. Initially, gene silencing by RNAi mechanism was believed to be specific requiring sequence homology between siRNA and target mRNA.
Muthappa, Senthil-Kumar +1 more
openaire +2 more sources
Cancer systems biology: Harnessing off-target effects.
Nature chemical biology, 2019The 'off-targets' of a drug are often poorly characterized yet could be harnessed in the treatment of complex diseases. A recent study used a small-molecule screening in non-small-cell lung cancer to repurpose an FDA-approved ALK/IGF1R inhibitor and uncover its mechanism of ...
Saginc, Gaye +2 more
openaire +2 more sources
Characterizing off-target effects of genome editors
Current Opinion in Biomedical Engineering, 2023Xichen Rao +3 more
openaire +1 more source
Radiotherapy combination opportunities leveraging immunity for the next oncology practice
Ca-A Cancer Journal for Clinicians, 2017Fernanda G Herrera +2 more
exaly
Off TARGET Effects in Stent Comparison Trials
Journal of the American College of CardiologyDaniel O’Callaghan +4 more
openaire +1 more source