Results 71 to 80 of about 14,327 (215)

Apigenin attenuates myocardial ischemia-reperfusion injury through miR-448/SIRT1 axis [PDF]

open access: yesIranian Journal of Basic Medical Sciences
Objective(s): Myocardial ischemia/reperfusion injury (MIRI) is the primary pathological injury following ischemic cardiomyocyte therapy, but there are few effective treatments available for MIRI. Apigenin (API) is an active ingredient of herbal medicine.
Chenchen Tian   +5 more
doaj   +1 more source

Increased expression of G protein-coupled receptor 84 after cerebral ischemia-reperfusion in rats [PDF]

open access: yesJichu yixue yu linchuang, 2021
Objective To determine the expression and function of G protein-coupled receptor 84 (GPR84) in rat cerebral ischemia-reperfusion(I/R). Methods The rat middle cerebral artery occlusion (MCAO) models were performed, and rats were then divided into sham ...
ZHAO Chong-chong, GUO Wen-ting, CAI Hong-bin, WANG Huan
doaj  

AntagomiR-451 inhibits oxygen glucose deprivation (OGD)-induced HUVEC necrosis via activating AMPK signaling. [PDF]

open access: yesPLoS ONE, 2017
Oxygen glucose deprivation (OGD) application in cultured human umbilical vein endothelial cells (HUVECs) mimics ischemic injuries. AntagomiR-451, the miroRNA-451 ("miR-451") inhibitor, could activate pro-survival AMP-activated protein kinase (AMPK ...
Xi Yang   +3 more
doaj   +1 more source

U.S. state and state capital open government data (OGD): A content examination and heuristic evaluation of data processing capabilities of OGD sites

open access: yesProceedings of the Association for Information Science and Technology, 2019
ABSTRACT This paper reports the results of a multi‐phased investigation into Open Government Data (OGD) sites in the United States. Upon searching and examining OGD sites by state and state capital, we outlined current OGD practice in the US.
Tang, Rong   +3 more
openaire   +2 more sources

Systemic Therapy for Advanced Hepatocellular Carcinoma in 2026: Current Standard‐of‐Care and Emerging Therapeutic Strategies

open access: yesJournal of Gastroenterology and Hepatology, EarlyView.
ABSTRACT Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer, accounting for up to 80% of all cases. Most patients present at an advanced stage and are unsuitable for curative treatments. In the past 5 years, immunotherapy combination has superseded tyrosine kinase inhibitors (TKI) as the standard first‐line therapy for ...
Landon L. Chan   +2 more
wiley   +1 more source

Cardiac shock wave therapy-induced exosome derived from OGD/R-treated H9c2 cells carrying miR-98-5p promote HUVECs angiogenesis

open access: yesScientific Reports
Cardiac shock wave therapy (CSWT) as an effectual therapy can activate the function of exosomes to a certain extent. Here, we attempted to examine the role of CSWT in exosome released from ischemic cardiomyocytes and its function in myocardial ischemia ...
Lizhou Wu   +5 more
doaj   +1 more source

Cardioprotective effects of prolyl hydroxylase inhibitors during reperfusion in myocardial infarction: A study using cardiosphere‐derived cells

open access: yesExperimental Physiology, EarlyView.
Abstract Cardiosphere‐derived cells (CDCs) are a promising in vitro model for studying myocardial ischaemia–reperfusion (I–R) injury and testing potential therapeutic interventions. This study investigated the suitability of CDCs as a model for myocardial infarction (MI) and the effects of prolyl hydroxylase inhibitor (PHI) administration during ...
Luca Salhöfer   +4 more
wiley   +1 more source

Effects and mechanism of dexmedetomidine on neuronal cell injury induced by hypoxia-ischemia

open access: yesBMC Anesthesiology, 2017
Background The present study aims to investigate the protective effects of dexmedetomidine (DMED) on hypoxia ischemia injury induced by oxygen and glucose deprivation (OGD) in PC12 and primary neuronal cells. Methods PC12 cells exposed to OGD was used to
Ya-Jun Liu   +3 more
doaj   +1 more source

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