Results 31 to 40 of about 11,397 (216)

OGG1 expression and OGG1 Ser326Cys polymorphism and risk of lung cancer in a prospective study

Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 2008
Oxidative DNA damage is believed to be implicated in lung carcinogenesis. 8-OxodG is a mutagenic and abundant oxidative modification induced in DNA. OGG1, NEIL1 and MUTYH are all involved in the repair and prevention of 8-oxodG-derived mutations and may be up-regulated by oxidative stress.
Hatt, Lotte, Loft, Steffen, Risom, Lotte, Møller, Peter, Sørensen, Mette, Raaschou-Nielsen, Ole, Overvad, Kim, Tjønneland, Anne, Vogel, Ulla   +8 more
openaire   +4 more sources

8-oxoguanine DNA glycosylase (OGG1) deficiency elicits coordinated changes in lipid and mitochondrial metabolism in muscle. [PDF]

PLoS ONE, 2017
Oxidative stress resulting from endogenous and exogenous sources causes damage to cellular components, including genomic and mitochondrial DNA. Oxidative DNA damage is primarily repaired via the base excision repair pathway that is initiated by DNA ...
Vladimir Vartanian, Jana Tumova, Pawel Dobrzyn, Agnieszka Dobrzyn, Yusaku Nakabeppu, R Stephen Lloyd, Harini Sampath   +6 more
doaj   +1 more source

OGG1 competitive inhibitors show important off-target effects by directly inhibiting efflux pumps and disturbing mitotic progression

Frontiers in Cell and Developmental Biology, 2023
One of the most abundant DNA lesions induced by Reactive oxygen species (ROS) is 8-oxoG, a highly mutagenic lesion that compromises genetic instability when not efficiently repaired.
Xhaferr Tanushi, Xhaferr Tanushi, Guillaume Pinna, Guillaume Pinna, Marie Vandamme, Marie Vandamme, Capucine Siberchicot, Capucine Siberchicot, Ostiane D’Augustin, Ostiane D’Augustin, Ostiane D’Augustin, Anne-Marie Di Guilmi, Anne-Marie Di Guilmi, J. Pablo Radicella, J. Pablo Radicella, Bertrand Castaing, Rebecca Smith, Sebastien Huet, Sebastien Huet, François Leteurtre, François Leteurtre, Anna Campalans, Anna Campalans   +22 more
doaj   +1 more source

Induction of OGG1 Gene Expression by HIV-1 Tat [PDF]

Journal of Biological Chemistry, 2005
To identify the cellular gene target for Tat, we performed gene expression profile analysis and found that Tat up-regulates the expression of the OGG1 (8-oxoguanine-DNA glycosylase-1) gene, which encodes an enzyme responsible for repairing the oxidatively damaged guanosine, 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxo-dG).
Kenichi, Imai, Kenji, Nakata, Kazuaki, Kawai, Takaichi, Hamano, Nan, Mei, Hiroshi, Kasai, Takashi, Okamoto   +6 more
openaire   +2 more sources

Effects of the stimuli-dependent enrichment of 8-oxoguanine DNA glycosylase1 on chromatinized DNA

Redox Biology, 2018
8-Oxoguanine DNA glycosylase 1 (OGG1) initiates the base excision repair pathway by removing one of the most abundant DNA lesions, 8-oxo-7,8-dihydroguanine (8-oxoG). Recent data showed that 8-oxoG not only is a pro-mutagenic genomic base lesion, but also
Wenjing Hao, Tianyang Qi, Lang Pan, Ruoxi Wang, Bing Zhu, Leopoldo Aguilera-Aguirre, Zsolt Radak, Tapas K. Hazra, Spiros A. Vlahopoulos, Attila Bacsi, Allan R. Brasier, Xueqing Ba, Istvan Boldogh   +12 more
doaj   +1 more source

Small molecule-mediated allosteric activation of the base excision repair enzyme 8-oxoguanine DNA glycosylase and its impact on mitochondrial function

Scientific Reports, 2022
8-Oxoguanine DNA glycosylase (OGG1) initiates base excision repair of the oxidative DNA damage product 8-oxoguanine. OGG1 is bifunctional; catalyzing glycosyl bond cleavage, followed by phosphodiester backbone incision via a β-elimination apurinic lyase ...
Gaochao Tian, Steven R. Katchur, Yong Jiang, Jacques Briand, Michael Schaber, Constantine Kreatsoulas, Benjamin Schwartz, Sara Thrall, Alicia M. Davis, Sam Duvall, Brett A. Kaufman, William L. Rumsey   +11 more
doaj   +1 more source

The basic chemistry of exercise-induced DNA oxidation:oxidative damage, redox signalling and their interplay [PDF]

, 2015
Acute exercise increases reactive oxygen and nitrogen species generation. This phenomenon is associated with two major outcomes: (1) redox signalling and (2) macromolecule damage.
Close, Graeme L., Cobley, James N., Malone, John K., Margaritelis, Nikos V., Morton, James P., Nikolaidis, Michalis G.   +5 more
core   +3 more sources

OGG1 is a novel prognostic indicator in acute myeloid leukaemia [PDF]

Oncogene, 2009
OGG1 (8-oxoguanine DNA glycosylase) constitutes a key component of the DNA base excision repair pathway, catalysing the removal of 8-oxoguanine nucleotides from DNA, thereby suppressing mutagenesis and cell death. We found that OGG1 expression was significantly downregulated by the RUNX1-ETO fusion protein product of the t(8;21) chromosome ...
K, Liddiard, R, Hills, A K, Burnett, R L, Darley, A, Tonks   +4 more
openaire   +2 more sources

Targeting DNA repair pathways for cancer therapy [PDF]

, 2017
Accumulation of genomic mutations is the consequence of failure in DNA repair as well as increased exposure to endogenous/environmental mutagens. DNA repair pathways safeguard the human genome from such mutagens, and thereby suppress the multi-step ...
Eshtad, Saeed
core   +1 more source

OGG1 co-inhibition antagonizes the tumor-inhibitory effects of targeting MTH1

Redox Biology, 2021
Cancer cells develop protective adaptations against oxidative DNA damage, providing a strong rationale for targeting DNA repair proteins. There has been a high degree of recent interest in inhibiting the mammalian Nudix pyrophosphatase MutT Homolog 1 ...
Ling Zhang, Laura Misiara, Govindi J. Samaranayake, Nisha Sharma, Dao M. Nguyen, Yu-Ki Tahara, Eric T. Kool, Priyamvada Rai   +7 more
doaj   +1 more source