Results 51 to 60 of about 11,397 (216)
Frontiers in Immunology, 2023 Recent advances have uncovered the non-random distribution of 7, 8-dihydro-8-oxoguanine (8-oxoGua) induced by reactive oxygen species, which is believed to have epigenetic effects.
Lang Pan +9 more
doaj +1 more source
MUTYH, an adenine DNA glycosylase, mediates p53 tumor suppression via PARP-dependent cell death [PDF]
, 2014 p53-regulated caspase-independent cell death has been implicated in suppression of tumorigenesis, however, the regulating mechanisms are poorly understood.
Leon, Julio +8 more
core +1 more source
DNA, 2022 DNA glycosylases promote genomic stability by initiating base excision repair (BER) in both the nuclear and mitochondrial genomes. Several of these enzymes have overlapping substrate recognition, through which a degree of redundancy in lesion recognition
R. Stephen Lloyd
doaj +1 more source
SLAB51 Probiotic Formulation Activates SIRT1 Pathway Promoting Antioxidant and Neuroprotective Effects in an AD Mouse Model [PDF]
, 2018 The gut-brain axis is a bidirectional communication network functionally linking the gut and the central nervous system (CNS). Based on this, the rational manipulation of intestinal microbiota represents a novel attractive therapeutic strategy for the ...
Angeletti, Mauro +7 more
core +1 more source
Cadmium Down-regulates Human OGG1 through Suppression of Sp1 Activity [PDF]
Journal of Biological Chemistry, 2005 Cadmium is a well known human and animal carcinogen and is a ubiquitous contaminant in the environment. Although the carcinogenic mechanism of cadmium is a multifactorial process, oxidative DNA damage is believed to be of prime importance. In particular, cadmium suppresses the capacity of cells to repair oxidative DNA damage.
Cha-Kyung, Youn +7 more
openaire +2 more sources
BMC Endocrine Disorders, 2002 Background It has become increasingly clear that β-cell failure plays a critical role in the pathogenesis of type 2 diabetes. Free-radical mediated β-cell damage has been intensively studied in type 1 diabetes, but not in human type 2 diabetes. Therefore,
Yoon Kun-Ho +5 more
doaj +1 more source
Poor maternal nutrition and accelerated postnatal growth induces an accelerated aging phenotype and oxidative stress in skeletal muscle of male rats [PDF]
, 2016 'Developmental programming', which occurs as a consequence of suboptimal in utero and early environments, can be associated with metabolic dysfunction in later life, including an increased incidence of cardiovascular disease and type 2 diabetes, and ...
Aiken, Catherine E +6 more
core +3 more sources
Polymorphisms in DNA repair genes increase the risk for type 2 diabetes mellitus and hypertension
Biomolecular Concepts, 2018 We investigated the effect of polymorphisms in four DNA repair genes, viz. RAD18 Arg302Gln (G>A) (rs373572), XPD Asp312Asn (G>A) (rs1799793), APE1 Asp148Glu (T>G) (rs3136820), and OGG1 Ser326Cys (C>G) (rs1052133) on the risk for type 2 diabetes mellitus (
Das Sambuddha +4 more
doaj +1 more source
Comet assay assessment of oleic acid-coated magnetite nanoparticles on human SHSY5Y neuronal cells [PDF]
, 2015 Superparamagnetic iron oxide nanoparticles (ION) have a wide range of potential applications. Among them, the most important uses in biology and medicine are as contrast agents in magnetic resonance imaging, as carriers for drug delivery or ...
Blanca, Laffon +7 more
core +1 more source
Dual Inhibitors of 8-Oxoguanine Surveillance by OGG1 and NUDT1 [PDF]
ACS Chemical Biology, 2019 Oxidative damage in DNA is one of the primary sources of mutations in the cell. The activities of repair enzymes 8-oxoguanine DNA glycosylase (OGG1) and human MutT Homologue 1 (NUDT1 or MTH1), which work together to ameliorate this damage, are closely linked to mutagenesis, genotoxicity, cancer, and inflammation. Here we have undertaken the development
Yu-ki Tahara +5 more
openaire +2 more sources