Results 1 to 10 of about 53,380 (165)
Odorant receptor co-receptors affect expression of tuning receptors in Drosophila
Frontiers in Cellular NeuroscienceInsects detect odorants using two large families of heteromeric receptors, the Odorant Receptors (ORs) and Ionotropic Receptors (IRs). Most OR and IR genes encode odorant-binding “tuning” subunits, whereas four (Orco, Ir8a, Ir25a, and Ir76b) encode co ...
Teng Long +5 more
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Dysregulation of Olfactory Receptor Neuron Lineage in Schizophrenia [PDF]
Archives of General Psychiatry, 2001 Growing evidence implicates abnormal neurodevelopment in schizophrenia. While neuron birth and differentiation is largely completed by the end of gestation, the olfactory epithelium (OE) is a unique part of the central nervous system that undergoes regeneration throughout life, thus offering an opportunity to investigate cellular and molecular events ...
S E, Arnold +6 more
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Nature CommunicationsThe nervous system flexibly processes information under different conditions. To do this, neural networks frequently rely on uniform expression of modulatory receptors by distinct classes of neurons to fine tune the computations supported by each ...
Julius Jonaitis +13 more
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Prion shedding from olfactory neurons into nasal secretions. [PDF]
PLoS Pathogens, 2010 This study investigated the role of prion infection of the olfactory mucosa in the shedding of prion infectivity into nasal secretions. Prion infection with the HY strain of the transmissible mink encephalopathy (TME) agent resulted in a prominent ...
Richard A Bessen +7 more
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Olfactory sensory neurons transiently express multiple olfactory receptors during development
Molecular Systems Biology, 2015 In mammals, each olfactory sensory neuron randomly expresses one, and only one, olfactory receptor (OR)--a phenomenon called the "one-neuron-one-receptor" rule. Although extensively studied, this rule was never proven for all ~1,000 OR genes in one cell at once, and little is known about its dynamics.
Tan, Longzhi, Li, Qian, Xie, X Sunney
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GPRC5C regulates the composition of cilia in the olfactory system
BMC Biology, 2023 Background Olfactory sensory neurons detect odourants via multiple long cilia that protrude from their dendritic endings. The G protein-coupled receptor GPRC5C was identified as part of the olfactory ciliary membrane proteome, but its function and ...
Sneha Bhat +6 more
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Trpc2-Expressing Sensory Neurons in the Main Olfactory Epithelium of the Mouse
Cell Reports, 2014 The mouse olfactory system contains two distinct chemosensory epithelia, the main olfactory epithelium (MOE) and the vomeronasal epithelium (VNE). Their sensory neurons express odorant receptor genes and vomeronasal receptor genes, respectively, and ...
Masayo Omura, Peter Mombaerts
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Alzheimer’s Disease: What Can We Learn From the Peripheral Olfactory System?
Frontiers in Neuroscience, 2020 The sense of smell has been shown to deteriorate in patients with some neurodegenerative disorders. In Parkinson’s disease (PD) and Alzheimer’s disease (AD), decreased ability to smell is associated with early disease stages.
Michele Dibattista +3 more
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Chromatin Modulatory Proteins and Olfactory Receptor Signaling in the Refinement and Maintenance of Fruitless Expression in Olfactory Receptor Neurons. [PDF]
PLoS Biology, 2016 During development, sensory neurons must choose identities that allow them to detect specific signals and connect with appropriate target neurons. Ultimately, these sensory neurons will successfully integrate into appropriate neural circuits to generate ...
Catherine E Hueston +6 more
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Most primary olfactory neurons have individually neutral effects on behavior
eLife, 2022 Animals use olfactory receptors to navigate mates, food, and danger. However, for complex olfactory systems, it is unknown what proportion of primary olfactory sensory neurons can individually drive avoidance or attraction.
Tayfun Tumkaya +5 more
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