Results 141 to 150 of about 244,975 (377)

GPCRs in CAR‐T Cell Immunotherapy: Expanding the Target Landscape and Enhancing Therapeutic Efficacy

Advanced Science, EarlyView.
Chimeric antigen receptor T cell therapy faces dual challenges of target scarcity and an immunosuppressive microenvironment in solid tumors. This review highlights how G protein‐coupled receptors can serve as both novel targets to expand the therapeutic scope and functional modules to enhance CAR‐T cell efficacy.
Zhuoqun Liu, Yuchen Xiao, Yamin Zhao, Lihe Dai, David J.H. Shih, Shikang Liang, Honglei Tian, Liu Liu, Feng Tian, Bing Liu, Lei Chang, Chao Zhang   +11 more
wiley   +1 more source

Gain control in olfactory receptor neurons and the detection of temporal fluctuations in odor concentration. [PDF]

Front Physiol, 2023
Tichy H, Hellwig M.
europepmc   +1 more source

Conservation of Olfactory Avoidance in Drosophila Species and Identification of Repellents for Drosophila suzukii. [PDF]

, 2015
Flying insects use olfaction to navigate towards fruits in complex odor environments with remarkable accuracy. Some fruits change odor profiles substantially during ripening and related species can prefer different stages.
Krause Pham, Christine, Ray, Anandasankar   +1 more
core  

Insect olfactory neurons: receptors, development, and function

Current Opinion in Insect Science
Insects represent the most diverse group of animals in the world. While the olfactory systems of different species share general principles of organization, they also exhibit a wide range of structural and functional diversity. Scientists have gained tremendous insight into olfactory neural development and function, notably in Drosophila, but also in ...
openaire   +2 more sources

AXL Promotes Ischemic Myelin Repair Through Alleviating Myelin Debris Deposition and Lipid Droplets Accumulation

Advanced Science, EarlyView.
Microglial AXL drives white matter repair after stroke by orchestrating the cleanup of myelin debris. Mechanistically, AXL signals through EGR1 to boost Smpd1 transcription, regulating sphingolipid metabolism and preventing lipid droplet toxicity. Restoring the pathway with ASM therapy mitigates damage, positioning AXL as a key node for therapeutic ...
Junqiu Jia, Yonghui Gan, Jia Li, Lilin Li, Hailan Meng, Min Sun, Lei Ye, Rui Mao, Xiang Cao, Shengnan Xia, Xinyu Bao, Renyuan Liu, Meijuan Zhang, Yun Xu   +13 more
wiley   +1 more source

Type I Interferon Receptor Signaling of Neurons and Astrocytes Regulates Microglia Activation during Viral Encephalitis

Cell Reports, 2018
Summary: In sterile neuroinflammation, a pathological role is proposed for microglia, whereas in viral encephalitis, their function is not entirely clear. Many viruses exploit the odorant system and enter the CNS via the olfactory bulb (OB).
Chintan Chhatbar, Claudia N. Detje, Elena Grabski, Katharina Borst, Julia Spanier, Luca Ghita, David A. Elliott, Marta Joana Costa Jordão, Nora Mueller, James Sutton, Chittappen K. Prajeeth, Viktoria Gudi, Michael A. Klein, Marco Prinz, Frank Bradke, Martin Stangel, Ulrich Kalinke   +16 more
doaj   +1 more source

Amelioration of Post‐Stroke Edema and Microcirculatory Dysfunction via Targeted AQP4 Inhibition While Preserving the Glymphatic System

Advanced Science, EarlyView.
Compared to untargeted therapy, the targeted nanocarrier, Angiopep‐2‐conjugated Lipid Nanoparticle (A‐LNP) loaded with TGN‐020 (TGN), selectively accumulated in stroke‐injured regions. It suppressed local aquaporin‐4 (AQP4) overexpression, thereby alleviating cerebral edema and hypoperfusion while preserving global glymphatic clearance.
Lei Jin, Zeyu Yang, Boyang Wei, Yu Wu, Longxiang Li, Jiaming Zhou, Xin Zhang, Fa Jin, Shixing Su, Yanchao Liu, Ran Li, Shenquan Guo, Xingwu Liu, Yu Cai, Hong Liu, Min Chen, Wenchao Liu, Chuanzhi Duan, Xifeng Li   +18 more
wiley   +1 more source

Olfactory receptor neurons generate multiple response motifs, increasing coding space dimensionality. [PDF]

Elife, 2023
Kim B, Haney S, Milan AP, Joshi S, Aldworth Z, Rulkov N, Kim AT, Bazhenov M, Stopfer MA.   +8 more
europepmc   +1 more source

Calcium Activates a Chloride Conductance Likely Involved in Olfactory Receptor Neuron Repolarization in the MothSpodoptera littoralis [PDF]

, 2010
Adeline Pézier, Marta Grauso, Adrien Acquistapace, Christelle Monsempès, Jean-Pierre Rospars, Philippe Lucas   +5 more
openalex   +1 more source

Functional classification and central nervous projections of olfactory receptor neurons housed in antennal trichoid sensilla of female yellow fever mosquitoes, Aedes aegypti

European Journal of Neuroscience, 2007
Mosquitoes are highly dependent on their olfactory system for, e.g. host location and identification of nectar‐feeding and oviposition sites. Odours are detected by olfactory receptor neurons (ORNs) housed in hair‐shaped structures, sensilla, on the ...
M. Ghaninia, R. Ignell, B. Hansson
semanticscholar   +1 more source