Results 111 to 120 of about 92,957 (356)
OSLO: Automatic Cell Counting and Segmentation for Oligodendrocyte Progenitor Cells [PDF]
arXiv, 2018 Reliable cell counting and segmentation of oligodendrocyte progenitor cells (OPCs) are critical image analysis steps that could potentially unlock mysteries regarding OPC function during pathology. We propose a saliency-based method to detect OPCs and use a marker-controlled watershed algorithm to segment the OPCs.
arxiv
Proceedings of the National Academy of Sciences of the United States of America, 2018 Significance TDP-43 is the defining pathological hallmark protein for two overlapping adult-onset neurodegenerative diseases, amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD).
Jia Wang +6 more
semanticscholar +1 more source
Advanced Science, EarlyView.In multiple sclerosis, the disruption of the blood‐spinal cord barrier (BSCB) induced by CXCL13 facilitates the infiltration of inflammatory cells into the central nervous system, resulting in demyelination and neuronal injury. Mechanistically, the deleterious impact of CXCL13 on the BSCB is associated with a reduction in tight junction protein ...
Jingjing Han +10 more
wiley +1 more source
Regulation of developing myelin sheath elongation by oligodendrocyte calcium transients in vivo
Nature Neuroscience, 2017 How action potentials regulate myelination by oligodendrocytes is uncertain. We show that neuronal activity raises [Ca2+]i in developing oligodendrocytes in vivo and that myelin sheath elongation is promoted by a high frequency of [Ca2+]i transients and ...
A. Krasnow +4 more
semanticscholar +1 more source
Modulation of Oligodendrocyte Differentiation by Mechanotransduction [PDF]
Frontiers in Cellular Neuroscience, 2016 Oligodendrocytes (OLs) are responsible for the myelination of axons in the central nervous system (CNS). The differentiation of OLs encompasses several stages, through which cells undergo dramatic biochemical and morphological changes. OL differentiation is modulated by soluble factors (SFs)-such as growth factors and hormones-, known to be essential ...
Tânia Lourenço +3 more
openaire +4 more sources
Mitochondrial network reorganization and transient expansion during oligodendrocyte generation
Nature CommunicationsOligodendrocyte precursor cells (OPCs) give rise to myelinating oligodendrocytes of the brain. This process persists throughout life and is essential for recovery from neurodegeneration.
Xhoela Bame, Robert A. Hill
doaj +1 more source
The Hypoxia‐Associated High‐Risk Cell Subpopulation Distinctly Enhances the Progression of Glioma
Advanced Science, EarlyView.This study suggests the potential roles of a novel hypoxia‐associated CDC20+KIF20A+PTTG1+ cell subpopulation in glioma progression. This high‐risk glioma cell subpopulation is therapeutically vulnerable to glioma progression and may play important roles in glioma standard‐of‐care therapeutic resistance.
Quan Wan +13 more
wiley +1 more source
A shared disease-associated oligodendrocyte signature among multiple CNS pathologies
Nature Neuroscience, 2022 M. Kenigsbuch +11 more
semanticscholar +1 more source
Neuronal activity regulates remyelination via glutamate signalling to oligodendrocyte progenitors
Nature Communications, 2015 Myelin regeneration can occur spontaneously in demyelinating diseases such as multiple sclerosis (MS). However, the underlying mechanisms and causes of its frequent failure remain incompletely understood.
H. Gautier +10 more
semanticscholar +1 more source
Phosphorylation State of ZFP24 Controls Oligodendrocyte Differentiation
Cell Reports, 2018 Summary: Zinc finger protein ZFP24, formerly known as ZFP191, is essential for oligodendrocyte maturation and CNS myelination. Nevertheless, the mechanism by which ZFP24 controls these processes is unknown.
Benayahu Elbaz +6 more
doaj