Results 131 to 140 of about 92,957 (356)

Imaging of non tumorous and tumorous human brain tissue with full-field optical coherence tomography [PDF]

arXiv, 2013
A prospective study was performed on neurosurgical samples from 18 patients to evaluate the use of Full-Field Optical Coherence Tomography (FF-OCT) in brain tumor diagnosis. FF-OCT captures en face slices of tissue samples at 1\mum resolution in 3D with a typical 200\mum imaging depth. A 1cm2 specimen is scanned at a single depth and processed in about
arxiv  

Three-dimensional co-culture platform of human induced pluripotent stem cell-derived oligodendrocyte lineage cells and neurons for studying myelination

STAR Protocols, 2023
Summary: Developing an in vitro platform to study neuron-oligodendrocyte interaction, particularly myelination, is essential to understand aberrant myelination in neuropsychiatric and neurodegenerative diseases.
Martina von der Bey, Silvia De Cicco, Susanne Zach, Bastian Hengerer, Ebru Ercan-Herbst   +4 more
doaj  

Early functional and structural hippocampal impairment in a bilateral common carotid artery stenosis mouse model

Animal Models and Experimental Medicine, EarlyView.
Our study used behavioral tests, laser speckle flowmetry, long‐term potentiation, histochemical staining, molecular experiments, and voxel‐based morphometry to evaluate the hippocampal impairments. It demonstrates early functional and structural impairments in the hippocampus contributing to learning and memory deficits after 1 month of BCAS ...
Ping Tang, Yi Sun, Chunsheng Yang, Nan Zhang   +3 more
wiley   +1 more source

The appearance of phagocytic microglia in the postnatal brain of Niemann Pick type C mice is developmentally regulated and underscores shortfalls in fine odor discrimination

Journal of Cellular Physiology, Volume 237, Issue 12, Page 4563-4579, December 2022., 2022
Abstract The loss of NPC1 or NPC2 function results in cholesterol and sphingolipid dyshomeostasis that impairs developmental trajectories, predisposing the postnatal brain to the appearance of pathological signs, including progressive and stereotyped Purkinje cell loss and microgliosis.
Alessandro Rava, Piergiorgio La Rosa, Giampiero Palladino, Jessica Dragotto, Antonio Totaro, Jessica Tiberi, Sonia Canterini, Sergio Oddi, Maria Teresa Fiorenza   +8 more
wiley   +1 more source

Modulation of oligodendrocyte differentiation and maturation by combined biochemical and mechanical cues

Scientific Reports, 2016
Extracellular matrix (ECM) proteins play a key role during oligodendrogenesis. While fibronectin (FN) is involved in the maintenance and proliferation of oligodendrocyte progenitor cells (OPCs), merosin (MN) promotes differentiation into oligodendrocytes
Tânia Lourenço, Joana Paes de Faria, Christian A. Bippes, J. Maia, J. A. Lopes-da-Silva, J. Relvas, M. Grãos   +6 more
semanticscholar   +1 more source

Synaptic vesicle release regulates pre-myelinating oligodendrocyte-axon interactions in a neuron subtype-specific manner

Frontiers in Cellular Neuroscience
Oligodendrocyte-lineage cells are central nervous system (CNS) glia that perform multiple functions including the selective myelination of some but not all axons.
James R. Gronseth, Heather N. Nelson, Taylor L. Johnson, Taryn A. Mallon, Madeline R. Martell, Katrina A. Pfaffenbach, Bailey B. Duxbury, John T. Henke, Anthony J. Treichel, Jacob H. Hines   +9 more
doaj   +1 more source

Targeting signaling pathways in neurodegenerative diseases: Quercetin's cellular and molecular mechanisms for neuroprotection

Animal Models and Experimental Medicine, EarlyView.
Quercetin regulates signaling pathways in neurodegenerative diseases, including NF‐κB, sirtuins, and PI3K/Akt. Studies show quercetin improves symptoms and pathology in neurodegenerative models. The study aims to incorporate laboratory research into practical medical treatment, focusing on quercetin's neuroprotective effects and optimal dosage ...
Md. Rezaul Islam, Md. Ibrahim Khalil Al‐Imran, Mehrukh Zehravi, Sherouk Hussein Sweilam, Mohammad Rakib Mortuza, Jeetendra Kumar Gupta, Thukani Sathanantham Shanmugarajan, Kadirvel Devi, Tanuja Tummala, Mohammed Ali Alshehri, Kalirajan Rajagopal, Mohammed Asiri, Irfan Ahmad, Talha Bin Emran   +13 more
wiley   +1 more source

The peritumoral brain zone in glioblastoma: where we are and where we are going

Journal of Neuroscience Research, Volume 101, Issue 2, Page 199-216, February 2023., 2023
Abstract Glioblastoma (GBM) is the most aggressive and invasive primary brain tumor. Current therapies are not curative, and patients' outcomes remain poor with an overall survival of 20.9 months after surgery. The typical growing pattern of GBM develops by infiltrating the surrounding apparent normal brain tissue within which the recurrence is ...
Martina Giambra, Andrea Di Cristofori, Silvia Valtorta, Roberto Manfrellotti, Vittorio Bigiogera, Gianpaolo Basso, Rosa Maria Moresco, Carlo Giussani, Angela Bentivegna   +8 more
wiley   +1 more source

Endogenous GABA controls oligodendrocyte lineage cell number, myelination, and CNS internode length

Glia, 2016
Adjusting the thickness and internodal length of the myelin sheath is a mechanism for tuning the conduction velocity of axons to match computational needs.
N. Hamilton, Laura E. Clarke, I. Arancibia‐Carcamo, E. Kougioumtzidou, Moritz Matthey, R. Káradóttir, Louise Whiteley, L. H. Bergersen, William D. Richardson, D. Attwell   +9 more
semanticscholar   +1 more source

Centenary of the oligodendrocyte

The Lancet Neurology, 2021
Madhuri Behari, Siddharthan Chandran, Arpan R Mehta, Owen G. James   +3 more
openaire   +4 more sources