Results 191 to 200 of about 63,056 (297)

TLR7 Mediates HIV‐1 Tat‐Induced Cellular Senescence in Human Astrocytes

Aging Cell, EarlyView.
Once internalized into endolysosomes, HIV‐1 Tat interacts and activates TLR7, causing endolysosome damage. Such interaction between HIV‐1 Tat and TLR7 also leads to a senescence‐like phenotype in astrocytes, including cell cycle arrest, elevated levels of p21 and p16 proteins, increased SA‐β‐gal activity, and enhanced secretion of SASP factors ...
Neda Rezagholizadeh, Gaurav Datta, Wendie A. Hasler, Erica C. Nguon, Elise V. Smokey, Xuesong Chen   +5 more
wiley   +1 more source

Myelin dysfunction in aging and brain disorders: mechanisms and therapeutic opportunities. [PDF]

Mol Neurodegener
Huang Z, Zhang Y, Zou P, Zong X, Zhang Q.   +4 more
europepmc   +1 more source

Elevated Levels of Antibody to Myelin Oligodendrocyte Glycoprotein Is Not Specific for Patients With Multiple Sclerosis

, 1999
Arnon Karni, Ronit Bakimer-Kleiner, Oded Abramsky, Avraham Ben‐Nun   +3 more
openalex   +1 more source

2′3′‐CNPase and actin distribution in oligodendrocytes, relative to their mRNAs [PDF]

, 1996
Neil McEwan
openalex   +1 more source

Human and Mouse Alzheimer's Seeds Differentially Affect Amyloid Deposition and Microglia‐Dependent Plaque Response in Aged Mice

Aging Cell, EarlyView.
This study shows that human and mouse brains contain a different pool of strains that differentially affect the formation of Aβ and tau aggregates. Moreover, the murine seeds trigger an unresponsiveness microglial state, which causes the loss of plaque microglial coverage and affects the formation of amyloid plaques, leading to more severe neuritic ...
Juana Andreo‐Lopez, Cristina Nuñez‐Diaz, Kelly Do Huynh, Marie Minh Thu Nguyen, Celia Da Cunha, Francisco J. Cantero‐Molina, Cynthia Campos‐Moreno, Stefania Zimbone, Francesco Bellia, Maria Laura Giuffrida, Laura Trujillo‐Estrada, Juan Antonio Garcia‐Leon, Miriam Bettinetti‐Luque, Nazaret Gamez, Catalina Valdes, Rodrigo Morales, Stefania Forner, Alessandra C. Martini, Antonia Gutierrez, Frank M. LaFerla, David Baglietto‐Vargas   +20 more
wiley   +1 more source

The X-Linked Intellectual Disability Gene, ZDHHC9 , Is Important for Oligodendrocyte Subtype Determination and Myelination. [PDF]

Glia
White RB, Wild AR, O'Leary TP, Thompson AJ, Flibotte S, Peng A, Rogalski JC, Mair M, Derhami N, Bamji SX.   +9 more
europepmc   +1 more source

Cross‐Analysis of Single‐Cell Transcriptomic Datasets Reveals Conserved Neurogenic Gene Signatures and New Insights Into Neural Stem Cell Aging

Aging Cell, EarlyView.
Here, we reanalyze single‐cell RNA sequencing datasets demonstrating hippocampal adult neural stem cell (NSC) heterogeneity to resolve classification inconsistencies and identify conserved gene markers. Our findings enhance understanding of NSC dynamics, aging, and senescence, providing a framework for standardized classification and improved insights ...
Oliver Polzer, E. Kinloch, P. J. Lucassen, E. Salta, C. P. Fitzsimons   +4 more
wiley   +1 more source

Unmasking Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease (MOGAD): CNS Demyelination Triggered by TNF-α Inhibition in a Patient with Ankylosing Spondylitis. [PDF]

Eur J Case Rep Intern Med
Baddam S, Patel S, Kahlon N, Thiriveedi M.   +3 more
europepmc   +1 more source

Contribution of Microglia/Macrophages to Expansion of Infarction and Response of Oligodendrocytes After Focal Cerebral Ischemia in Rats [PDF]

, 2000
Takuma Mabuchi, Kazuo Kitagawa, Toshiho Ohtsuki, Keisuke Kuwabara, Yoshiki Yagita, Takehiko Yanagihara, Masatsugu Hori, Masayasu Matsumoto   +7 more
openalex   +1 more source

Patient‐Derived Cortical Organoids Reveal Senescence of Neural Progenitor Cells in Hutchinson‐Gilford Progeria Syndrome

Aging Cell, EarlyView.
HGPS patient‐derived cortical organoids exhibit progerin accumulation, nuclear abnormalities, and increased senescence in rosette structures, leading to impaired neuronal differentiation and altered gene expression. ABSTRACT Hutchinson‐Gilford progeria syndrome (HGPS) is a rare genetic disorder characterized by premature aging and primarily caused by ...
Seeun Jeon, Chul‐Sung Park, Juyoung Hong, Jieun Kim, Yun Jin Lee, Junho K. Hur, Ji Yeoun Lee   +6 more
wiley   +1 more source