Results 201 to 210 of about 63,056 (297)
Impaired remyelination in late-onset multiple sclerosis. [PDF]
Stork L+4 more
europepmc +1 more source
Age‐Related Complement C3 Drives Memory Impairments and Associated Neuropathologies in a Mouse Model
Age‐related complement C3 elevation induces memory impairments and neuropathology by dysregulating astrocytic insulin signaling and triggering mitochondrial dysfunction. Critically, antibody blockade of C3 in mouse brain tissue effectively reversed learning and memory deficits in mice, demonstrating that targeting C3 is a promising therapeutic strategy.
Miaomiao Du+10 more
wiley +1 more source
Single-Cell RNA Sequencing and Spatial Transcriptomics Reveal a Novel Mechanism of Oligodendrocyte-Neuron Interaction in Cognitive Decline After High-Altitude Cerebral Edema. [PDF]
Lv W+9 more
europepmc +1 more source
Identification of a Novel Family of Oligodendrocyte Lineage-Specific Basic Helix–Loop–Helix Transcription Factors [PDF]
Qiao Zhou+2 more
openalex +1 more source
We have sought to determine the role that cholesterol metabolism plays in disability worsening and its correlation with progressive MS by analysing patient CSF and post‐mortem tissues using cutting edge mass spectrometry approaches. Key sterol metabolites measured in the CSF link with important disability milestones at the very early stages of MS ...
Lauren Griffiths+13 more
wiley +1 more source
Complement inhibition rapidly blocks lesion extension and facilitates remyelination in neuromyelitis optica. [PDF]
Given KS+5 more
europepmc +1 more source
HSV‐1 infection alters MAPT splicing and promotes Tau pathology in neural models of Alzheimer's disease. HSV‐1 infection in brain organoids and neuronal models increase 4R‐MAPT splicing and Tau hyperphosphorylation. HSV‐1 ICP27 is both necessary and sufficient for inducing these changes highlighting the potential role of HSV‐1 in Alzheimer's disease ...
Emmanuel C. Ijezie+9 more
wiley +1 more source
Development and Differentiation of Oligodendrocytes.
Masahisa Yamada+2 more
openaire +4 more sources
Quantitative T1 is sensitive to cortical remyelination in multiple sclerosis: A postmortem MRI study
In a post‐mortem study using multiparametric qMRI of whole fixed human brains from people with multiple sclerosis (pwMS), we found evidence that quantitative T1 (qT1) is sensitive to remyelination in the cortex. In contrast, QSM and radial diffusivity were affected by cortical pathology independently of remyelination. Our data suggest that qT1 could be
Riccardo Galbusera+14 more
wiley +1 more source