Results 201 to 210 of about 100,602 (348)

Amyloid‐β Dysregulates Oligodendroglial Lineage Cell Dynamics and Myelination via PKC in the Zebrafish Spinal Cord

open access: yesGlia, EarlyView.
Amyloid‐β peptide induces early oligodendrocyte differentiation and dorsal myelination in the zebrafish larvae spinal cord. Pan‐PKC inhibitor Gö6983 restores the aforementioned alterations in oligodendrocytes and myelin. ABSTRACT Soluble forms of amyloid‐β (Aβ) peptide have been proposed as candidates to induce oligodendrocyte (OL) and myelin ...
Uxue Balantzategi   +7 more
wiley   +1 more source

Hypothesis review: Alzheimer's overture guidelines

open access: yesBrain Pathology, Volume 33, Issue 1, January 2023., 2023
Brain aging with ADNC and sporadic Alzheimer's disease (sAD) form a prevalent continuum unique to humans. Molecular changes affecting cell membranes, cytoskeleton, synapses, lipid and protein metabolism, energy metabolism, neuroinflammation, cell cycle, astrocytes, microglia, and blood vessels precede and occur in parallel with early ADNC; and they are
Isidro Ferrer
wiley   +1 more source

The X‐Linked Intellectual Disability Gene, ZDHHC9, Is Important for Oligodendrocyte Subtype Determination and Myelination

open access: yesGlia, EarlyView.
Zdhhc9 ablation grossly changes gene expression and myelin protein levels in CNS WM. Zdhhc9 is important for the establishment of mature oligodendrocyte subtypes. Zdhhc9 is important for axon myelination and the maintenance of myelin integrity. ABSTRACT Two percent of patients with X‐linked intellectual disability (XLID) exhibit loss‐of‐function ...
Rocio B. White   +9 more
wiley   +1 more source

The fate of interneurons, GABAA receptor sub‐types and perineuronal nets in Alzheimer's disease

open access: yesBrain Pathology, Volume 33, Issue 1, January 2023., 2023
Abstract Alzheimer's disease (AD) is the most common neurological disease, which is associated with gradual memory loss and correlated with synaptic hyperactivity and abnormal oscillatory rhythmic brain activity that precedes phenotypic alterations and is partly responsible for the spread of the disease pathology.
Afia B. Ali   +2 more
wiley   +1 more source

Multi‐Omic Analysis Reveals Astrocytic Annexin‐A2 as Critical for Network‐Level Circadian Timekeeping in the Suprachiasmatic Nucleus

open access: yesGlia, EarlyView.
ABSTRACT The mammalian suprachiasmatic nucleus (SCN) orchestrates daily (circadian) rhythms of physiology and behavior by broadcasting timing cues generated autonomously by its mutually reinforcing network of ~10,000 neurons and ~3000 astrocytes. Although astrocytic control of extracellular glutamate and GABA has been implicated in driving circadian ...
Andrew P. Patton   +6 more
wiley   +1 more source

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