Results 201 to 210 of about 63,056 (297)

Impaired remyelination in late-onset multiple sclerosis. [PDF]

Acta Neuropathol
Stork L, Stephan S, Kutllovci A, Brück W, Metz I.   +4 more
europepmc   +1 more source

Age‐Related Complement C3 Drives Memory Impairments and Associated Neuropathologies in a Mouse Model

Aging Cell, EarlyView.
Age‐related complement C3 elevation induces memory impairments and neuropathology by dysregulating astrocytic insulin signaling and triggering mitochondrial dysfunction. Critically, antibody blockade of C3 in mouse brain tissue effectively reversed learning and memory deficits in mice, demonstrating that targeting C3 is a promising therapeutic strategy.
Miaomiao Du, Yujia Wang, Xinyuan Wang, Yifei Liu, Fuchuan Xiao, Jing Zhang, Xia Meng, Kunhe Ma, Na Wu, Baian Chen, Jing Lu   +10 more
wiley   +1 more source

Single-Cell RNA Sequencing and Spatial Transcriptomics Reveal a Novel Mechanism of Oligodendrocyte-Neuron Interaction in Cognitive Decline After High-Altitude Cerebral Edema. [PDF]

CNS Neurosci Ther
Lv W, Ma Y, Li D, Xiong K, Cui J, Pan S, Zhang N, Li Y, Chen Y, Guo D.   +9 more
europepmc   +1 more source

Identification of a Novel Family of Oligodendrocyte Lineage-Specific Basic Helix–Loop–Helix Transcription Factors [PDF]

, 2000
Qiao Zhou, Songli Wang, David J. Anderson   +2 more
openalex   +1 more source

Sterol imbalances and cholesterol‐24‐hydroxylase dysregulation is linked to the underlying progression of multiple sclerosis

Brain Pathology, EarlyView.
We have sought to determine the role that cholesterol metabolism plays in disability worsening and its correlation with progressive MS by analysing patient CSF and post‐mortem tissues using cutting edge mass spectrometry approaches. Key sterol metabolites measured in the CSF link with important disability milestones at the very early stages of MS ...
Lauren Griffiths, Kristen Hawkins, Eylan Yutuc, Roberto Angelini, Racheal Fosuah, Manuela Pacciarini, Alison Dickson, Neil Robertson, Laura Childs, Samantha Loveless, Emma Tallantyre, William J. Griffiths, Yuqin Wang, Owain W. Howell   +13 more
wiley   +1 more source

Complement inhibition rapidly blocks lesion extension and facilitates remyelination in neuromyelitis optica. [PDF]

Acta Neuropathol Commun
Given KS, Acker EG, Macklin WB, Carlin D, Owens GP, Bennett JL.   +5 more
europepmc   +1 more source

Herpes simplex virus‐1 infection alters microtubule‐associated protein Tau splicing and promotes Tau pathology in neural models of Alzheimer's disease

Brain Pathology, EarlyView.
HSV‐1 infection alters MAPT splicing and promotes Tau pathology in neural models of Alzheimer's disease. HSV‐1 infection in brain organoids and neuronal models increase 4R‐MAPT splicing and Tau hyperphosphorylation. HSV‐1 ICP27 is both necessary and sufficient for inducing these changes highlighting the potential role of HSV‐1 in Alzheimer's disease ...
Emmanuel C. Ijezie, Michael J. Miller, Celine Hardy, Ava R. Jarvis, Timothy F. Czajka, Lianna D'Brant, Natasha Rugenstein, Adam Waickman, Eain Murphy, David C. Butler   +9 more
wiley   +1 more source

Accumulation of the cyclin-dependent kinase inhibitor p27/Kip1 and the timing of oligodendrocyte differentiation

, 1997
Béatrice Durand
openalex   +2 more sources

Development and Differentiation of Oligodendrocytes.

The Japanese Journal of Physiology, 1996
Masahisa Yamada, Kazuhiro Ikenaka, Tetsushi Kagawa   +2 more
openaire   +4 more sources

Quantitative T1 is sensitive to cortical remyelination in multiple sclerosis: A postmortem MRI study

Brain Pathology, EarlyView.
In a post‐mortem study using multiparametric qMRI of whole fixed human brains from people with multiple sclerosis (pwMS), we found evidence that quantitative T1 (qT1) is sensitive to remyelination in the cortex. In contrast, QSM and radial diffusivity were affected by cortical pathology independently of remyelination. Our data suggest that qT1 could be
Riccardo Galbusera, Matthias Weigel, Erik Bahn, Sabine Schaedelin, Alessandro Cagol, Po‐Jui Lu, Muhamed Barakovic, Lester Melie‐Garcia, Jonas Franz, Peter Dechent, Govind Nair, Ludwig Kappos, Wolfgang Brück, Christine Stadelmann, Cristina Granziera   +14 more
wiley   +1 more source