Results 251 to 260 of about 63,056 (297)

Myeloid PD‐1 Regulates Astrocyte Development and Leads to Active Behaviours

Cell Proliferation, EarlyView.
During early neurodevelopment, PD‐1 ablation in myeloid cells influences myeloid proliferation/differentiation and causes sustained astrocyte overproliferation. PD‐1f/f; LysM‐Cre mice showed elevated astrocyte gene expression and behavioural changes.
Jie Qin, Chong Wang, Sihan Li, Yanyan Wang, Tingting He, Jianwei Jiao, Fen Ji   +6 more
wiley   +1 more source

The potential of repurposing clemastine to promote remyelination. [PDF]

Front Cell Neurosci
Yamazaki R, Ohno N.
europepmc   +1 more source

Pathogenic variants in chromatin‐related genes: Linking immune dysregulation to neuroregression and acute neuropsychiatric disorders

Developmental Medicine &Child Neurology, EarlyView.
Chromatin machinery influences how DNA is ‘wrapped’ around histones in the nucleosome of immune and brain cells. Plain language summary: https://onlinelibrary.wiley.com/doi/10.1111/dmcn.16299 Abstract We report eight children with de novo pathogenic DNA variants in chromatin‐related genes: MORC2, CHD7, KANSL1, KMT2D, ZMYND11, HIST1HIE, EP300, and KMT2B.
Russell C. Dale, Shekeeb Mohammad, Velda X. Han, Hiroya Nishida, Himanshu Goel, Stuart G. Tangye, Georgina Hollway, Esther Tantsis, Deepak Gill, Shrujna Patel, Chromatin Immune‐Brain Group, Michael Lonergan, Melanie Wong, Kavitha Kothur, Erica Tsang   +14 more
wiley   +1 more source

Oligodendrocyte-astrocyte crosstalk in Parkinson's disease mediates neuronal ferroptosis via the FGF signaling pathway. [PDF]

NPJ Parkinsons Dis
Zhang S, Yan M, Jiang X, Liu Y, Ma W, Ding L, Lu Z, Luo Y, Tian X, Wang Q.   +9 more
europepmc   +1 more source

Zebrafish in neurodevelopmental disorders studies: Genetic models and pathological involvement of microglia

Developmental Medicine &Child Neurology, EarlyView.
The relevance of the pathogenic (de novo or inherited) mutations found in patients with neurodevelopmental disorders can be investigated using zebrafish as an animal model, by functional screening of the target genes and phenotypic assessments during both early development and adulthood. Abstract Neurodevelopmental disorders (NDDs) are a group of brain
Fatemeh Hassani Nia, Valerie Wittamer
wiley   +1 more source

Incomplete remyelination via therapeutically enhanced oligodendrogenesis is sufficient to recover visual cortical function. [PDF]

Nat Commun
Della-Flora Nunes G, Osso LA, Haynes JA, Conant L, Thornton MA, Stockton ME, Brassell KA, Morris A, Mancha Corchado YI, Gaynes JA, Chavez AR, Woerner MB, MacKenna DA, Alavi A, Danks A, Poleg-Polsky A, Gandhi R, Vivian JA, Denman DJ, Hughes EG.   +19 more
europepmc   +1 more source

Alterations in the functional MRI‐based temporal brain organisation in individuals with obesity

Diabetes, Obesity and Metabolism, EarlyView.
Abstract Aims Obesity is associated with functional alterations in the brain. Although spatial organisation changes in the brains of individuals with obesity have been widely studied, the temporal dynamics in their brains remain poorly understood.
Seoah Lee, Jong Young Namgung, Jae‐Ho Han, Bo‐yong Park   +3 more
wiley   +1 more source

MRI signatures of cortical microstructure in human development align with oligodendrocyte cell-type expression. [PDF]

Nat Commun
Genc S, Ball G, Chamberland M, Raven EP, Tax CMW, Ward I, Yang JYM, Palombo M, Jones DK.   +8 more
europepmc   +1 more source

Immunity and neuroinflammation in early stages of life and epilepsy

Epilepsia, EarlyView.
Abstract The immune system is crucial for the correct brain development, and recent findings also point toward central control of immune response. As the immune system is not fully developed at birth, the early years become an important window for infections and for the development of epilepsy.
Angelica Vega García, María Leonor López‐Meraz, Marco I. González, Luisa Rocha, Jose Eduardo Peixoto‐Santos, Esper Abrão Cavalheiro   +5 more
wiley   +1 more source

Cognitive Profile in Adult Patients With Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease: A Comparative Study With Multiple Sclerosis. [PDF]

Eur J Neurol
Maniscalco GT, Ziello AR, Mantovani E, Dinoto A, Di Giulio Cesare D, Moreggia O, Di Battista ME, Carta S, Chiodega V, Stoppele E, Ferrari S, Andreone V, Tamburin S, Mariotto S.   +13 more
europepmc   +1 more source