Myeloid PD‐1 Regulates Astrocyte Development and Leads to Active Behaviours
During early neurodevelopment, PD‐1 ablation in myeloid cells influences myeloid proliferation/differentiation and causes sustained astrocyte overproliferation. PD‐1f/f; LysM‐Cre mice showed elevated astrocyte gene expression and behavioural changes.
Jie Qin+6 more
wiley +1 more source
The potential of repurposing clemastine to promote remyelination. [PDF]
Yamazaki R, Ohno N.
europepmc +1 more source
Chromatin machinery influences how DNA is ‘wrapped’ around histones in the nucleosome of immune and brain cells. Plain language summary: https://onlinelibrary.wiley.com/doi/10.1111/dmcn.16299 Abstract We report eight children with de novo pathogenic DNA variants in chromatin‐related genes: MORC2, CHD7, KANSL1, KMT2D, ZMYND11, HIST1HIE, EP300, and KMT2B.
Russell C. Dale+14 more
wiley +1 more source
Oligodendrocyte-astrocyte crosstalk in Parkinson's disease mediates neuronal ferroptosis via the FGF signaling pathway. [PDF]
Zhang S+9 more
europepmc +1 more source
The relevance of the pathogenic (de novo or inherited) mutations found in patients with neurodevelopmental disorders can be investigated using zebrafish as an animal model, by functional screening of the target genes and phenotypic assessments during both early development and adulthood. Abstract Neurodevelopmental disorders (NDDs) are a group of brain
Fatemeh Hassani Nia, Valerie Wittamer
wiley +1 more source
Incomplete remyelination via therapeutically enhanced oligodendrogenesis is sufficient to recover visual cortical function. [PDF]
Della-Flora Nunes G+19 more
europepmc +1 more source
Alterations in the functional MRI‐based temporal brain organisation in individuals with obesity
Abstract Aims Obesity is associated with functional alterations in the brain. Although spatial organisation changes in the brains of individuals with obesity have been widely studied, the temporal dynamics in their brains remain poorly understood.
Seoah Lee+3 more
wiley +1 more source
MRI signatures of cortical microstructure in human development align with oligodendrocyte cell-type expression. [PDF]
Genc S+8 more
europepmc +1 more source
Immunity and neuroinflammation in early stages of life and epilepsy
Abstract The immune system is crucial for the correct brain development, and recent findings also point toward central control of immune response. As the immune system is not fully developed at birth, the early years become an important window for infections and for the development of epilepsy.
Angelica Vega García+5 more
wiley +1 more source
Cognitive Profile in Adult Patients With Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease: A Comparative Study With Multiple Sclerosis. [PDF]
Maniscalco GT+13 more
europepmc +1 more source