Results 271 to 280 of about 97,181 (355)

CNS Mitochondria-Derived Vesicle in Blood: Potential Biomarkers for Brain Mitochondria Dysfunction. [PDF]

Ann Clin Transl Neurol
Liu Q, Chen W, Wu Y, Guo Z, Chen J, Tian C, Wang P, Zeng S, Xu B, Duan J, Han S, Xiong X, Zhang J.   +12 more
europepmc   +1 more source

Senescent Microglia Mediate Neuroinflammation‐Induced Cognitive Dysfunction by Selective Elimination of Excitatory Synapses in the Hippocampal CA1

Aging Cell, EarlyView.
In the CA1, microglia are activated to be responsible for synaptic pruning. However, LPS induces a senescent phenotype in microglia, characterized by the elevated levels of p16, as well as the production of SASPs. These senescent microglia mediate the removal of excitatory synapses selectively, resulting in dendritic spine loss and LTP impairment ...
Kai Liu, Di Fan, Hai‐peng Wu, Xiao‐yi Hu, Qiu‐li He, Xin‐miao Wu, Cui‐na Shi, Jian‐jun Yang, Mu‐huo Ji   +8 more
wiley   +1 more source

Oligodendrocyte arrangement, identification and morphology in the developing superior olivary complex. [PDF]

Front Cell Neurosci
Zacher AC, Grabinski M, Console-Meyer L, Felmy F, Pätz-Warncke C.   +4 more
europepmc   +1 more source

cTAGE5/MEA6 Regulates LBR Localization to Maintain Nuclear Envelope Integrity and Safeguard Against Aging

Aging Cell, EarlyView.
cTAGE5 regulates LBR trafficking between the ER and the nucleus membrane to maintain the integrity of both the ER and the nuclear envelope. cTAGE5 KO results in LBR retention in the ER, reduced stability, and subsequent disruption of nuclear envelope integrity. ABSTRACT cTAGE5/MEA6 plays a pivotal role in COPII complex assembly, ER‐to‐Golgi trafficking,
Yaqing Wang, Pengyu Sun, Fuqiang Yang, Tiantian Ma, Junwan Fan, Lei Shi, Nan Li, Fei Gao, Kangmin He, Zhiheng Xu   +9 more
wiley   +1 more source

The Lipid Peroxidation By-product 4-Hydroxynonenal is Toxic to Axons and Oligodendrocytes

, 2000
Eileen McCracken, V. Valeriani, C.S. Simpson, Teresa Jover, James McCulloch, Deborah Dewar   +5 more
openalex   +1 more source

Microglial States Are Susceptible to Senescence and Cholesterol Dysregulation in Alzheimer's Disease

Aging Cell, EarlyView.
Senescent microglia in Alzheimer's disease exhibit dysregulated cholesterol metabolism and express Disease‐Associated Microglia (DAM) signatures, including inflammatory and phagocytic markers. Single‐nucleus RNA‐seq from human brain tissues identified cholesterol‐related senescence gene co‐expression modules linked to microglial senescence.
Boyang Li, Shaowei Wang, Bilal Kerman, Cristelle Hugo, E. Keats Shwab, Chang Shu, Ornit Chiba‐Falek, Zoe Arvanitakis, Hussein N. Yassine   +8 more
wiley   +1 more source

A human iPSC-Derived myelination model for investigating fetal brain injuries. [PDF]

Regen Ther
Hiraiwa T, Yoshii S, Kawada J, Sugawara T, Kawasaki T, Shibata S, Shindo T, Fujimori K, Umezawa A, Akutsu H.   +9 more
europepmc   +1 more source

Normal Ageing Impacts the Extent and Diversity of Neural Plasticity Induced in the Mouse Brain With Repetitive Transcranial Magnetic Stimulation

Aging Cell, EarlyView.
With advancing age, the ability of repetitive transcranial magnetic stimulation (rTMS) to induce numerous different plasticity mechanisms is reduced compared to a young adult brain. Our results demonstrate that the effect of age on rTMS‐induced gene expression varies across different brain regions and is dependent on the stimulation protocol used ...
Rebecca C. S. Ong, Alexander D. Tang
wiley   +1 more source