Results 271 to 280 of about 100,602 (348)

Akt-Mediated Survival of Oligodendrocytes Induced by Neuregulins [PDF]

open access: hybrid, 2000
Ana I. Flores   +6 more
openalex   +1 more source

Development and Differentiation of Oligodendrocytes.

open access: yesThe Japanese Journal of Physiology, 1996
Masahisa Yamada   +2 more
openaire   +4 more sources

Elevated p16Ink4a Expression Enhances Tau Phosphorylation in Neurons Differentiated From Human‐Induced Pluripotent Stem Cells

open access: yesAging Cell, EarlyView.
We created an inducible system to control the expression of p16, and found that tau phosphorylation was enhanced upon p16 up‐regulation in neurons differentiated from human iPSCs. As p16 expression is increased during aging, our findings suggest a possible role of age‐associated p16 up‐regulation in Alzheimer's disease. As pathological tau tangles have
Kristopher Holloway   +7 more
wiley   +1 more source

Sonic Hedgehog–Regulated Oligodendrocyte Lineage Genes Encoding bHLH Proteins in the Mammalian Central Nervous System [PDF]

open access: bronze, 2000
Q. Richard Lu   +8 more
openalex   +1 more source

Intermittent Fasting Enhances Motor Coordination Through Myelin Preservation in Aged Mice

open access: yesAging Cell, EarlyView.
Over a 10‐week regimen, IMF significantly improved locomotor activity, motor coordination, and muscle strength compared to controls (p < 0.01). Resting‐state fMRI (rsfMRI) demonstrated that IMF modulates brain‐wide functional connectivity, enhancing communication between key brain regions.
Zhuang Liu   +12 more
wiley   +1 more source

Disease Aggravation With Age in an Experimental Model of Multiple Sclerosis: Role of Immunosenescence

open access: yesAging Cell, EarlyView.
Age‐related differences in EAE outcomes stem from combined peripheral and CNS factors. Key peripheral adaptive immunity changes include altered naïve/memory T cell ratios, Th1 skewing, increased suppressive Tregs, CD4+ T cell exhaustion, enhanced B cell antigen presentation, and reduced NK cell cytotoxicity.
María Dema   +6 more
wiley   +1 more source

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