Results 21 to 30 of about 63,056 (297)

Demyelination and oligodendrocytes

open access: yesRinsho Shinkeigaku, 2011
Although neurological sequelae are attributable to poor regeneration of the central nervous system, oligodendrocytes demonstrate robust regenerative response even in adults. Accumulating evidence indicates that the glial cells identified by surface expression of the proteoglycan NG2 are the cellular source of newly-developed oligodendrocytes following ...
Aki Itoh   +4 more
openaire   +3 more sources

Oligodendrocytes in intracerebral hemorrhage [PDF]

open access: yesCNS Neuroscience & Therapeutics, 2019
AbstractIntracerebral hemorrhage (ICH) is a cerebrovascular disorder with high mortality and disability rates. Although a lot of effort has been put in ICH, there is still no effective treatment for this devastating disease. Recent studies suggest that oligodendrocytes play an important role in brain repair after ICH and thus may be targeted for the ...
Minkyung Kang, Yao Yao
openaire   +3 more sources

pH Microdomains in Oligodendrocytes [PDF]

open access: yesJournal of Biological Chemistry, 2004
Oligodendrocytes (OLs) are cells that produce myelin in the central nervous system. Here we use ratiometric pH indicator dye to analyze intracellular pH in OLs in culture. The results reveal alkaline microdomains, which predominate in the perikaryon and proximal dendrites, and acidic microdomains, which predominate in distal dendrites.
Hyun-ah Ro, John H. Carson
openaire   +3 more sources

Stalled oligodendrocyte differentiation in IDH-mutant gliomas

open access: yesGenome Medicine, 2023
Background Roughly 50% of adult gliomas harbor isocitrate dehydrogenase (IDH) mutations. According to the 2021 WHO classification guideline, these gliomas are diagnosed as astrocytomas, harboring no 1p19q co-deletion, or oligodendrogliomas, harboring ...
Yanfei Wei   +17 more
doaj   +1 more source

Hepatoma Derived Growth Factor Enhances Oligodendrocyte Genesis from Subventricular Zone Precursor Cells

open access: yesASN Neuro, 2022
Oligodendrocytes, the myelinating cells of the central nervous system (CNS), perform vital functions in neural protection and communication, as well as cognition.
Yutong Li   +5 more
doaj   +1 more source

Folate Metabolism Regulates Oligodendrocyte Survival and Differentiation by Modulating AMPKα Activity

open access: yesScientific Reports, 2017
Folate, an essential micronutrient, is a critical cofactor in one-carbon metabolism for many cellular pathways including DNA synthesis, metabolism and maintenance.
Qinjie Weng   +9 more
doaj   +1 more source

Circulating transforming growth factor-β1 facilitates remyelination in the adult central nervous system

open access: yeseLife, 2019
Oligodendrocyte maturation is necessary for functional regeneration in the CNS; however, the mechanisms by which the systemic environment regulates oligodendrocyte maturation is unclear. We found that Transforming growth factor (TGF)-β1, which is present
Machika Hamaguchi   +5 more
doaj   +1 more source

Human induced pluripotent stem cells differentiation into oligodendrocyte progenitors and transplantation in a rat model of optic chiasm demyelination. [PDF]

open access: yesPLoS ONE, 2011
BACKGROUND: This study aims to differentiate human induced pluripotent stem cells (hiPSCs) into oligodendrocyte precursors and assess their recovery potential in a demyelinated optic chiasm model in rats.
Alireza Pouya   +4 more
doaj   +1 more source

GluA2 overexpression in oligodendrocyte progenitors promotes postinjury oligodendrocyte regeneration [PDF]

open access: yesCell Reports, 2021
Oligodendrocyte precursor cells (OPCs) are essential for developmental myelination and oligodendrocyte regeneration after CNS injury. These progenitors express calcium-permeable AMPA receptors (AMPARs) and form direct synapses with neurons throughout the CNS, but the roles of this signaling are unclear.
Rabia R. Khawaja   +8 more
openaire   +4 more sources

mTOR: A Link from the Extracellular Milieu to Transcriptional Regulation of Oligodendrocyte Development

open access: yesASN Neuro, 2013
Oligodendrocyte development is controlled by numerous extracellular signals that regulate a series of transcription factors that promote the differentiation of oligodendrocyte progenitor cells to myelinating cells in the central nervous system.
Teresa L. Wood   +6 more
doaj   +1 more source

Home - About - Disclaimer - Privacy