Results 21 to 30 of about 97,181 (355)
Neuron-Oligodendrocyte Interactions in the Structure and Integrity of Axons
Frontiers in Cell and Developmental Biology, 2021 The myelination of axons by oligodendrocytes is a highly complex cell-to-cell interaction. Oligodendrocytes and axons have a reciprocal signaling relationship in which oligodendrocytes receive cues from axons that direct their myelination, and ...
G. Duncan, Tyrell J Simkins, B. Emery
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Oligodendrocyte precursor cell maturation: role of adenosine receptors
Neural Regeneration Research, 2021 Oligodendrocyte-formed myelin sheaths allow fast synaptic transmission in the brain and their degeneration leads to demyelinating diseases such as multiple sclerosis.
Federica Cherchi +2 more
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Nature Reviews Neuroscience, 2006 Oligodendrocyte precursors first arise in a restricted ventral part of the embryonic spinal cord and migrate laterally and dorsally from there. Later, secondary sources develop in the dorsal cord. Normally, the ventrally-derived precursors compete with and suppress their dorsal counterparts.
William D, Richardson +2 more
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Oligodendrocytes: biology and pathology [PDF]
Acta Neuropathologica, 2009 Oligodendrocytes are the myelinating cells of the central nervous system (CNS). They are the end product of a cell lineage which has to undergo a complex and precisely timed program of proliferation, migration, differentiation, and myelination to finally produce the insulating sheath of axons.
Hans Lassmann, Monika Bradl
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High Yield of Adult Oligodendrocyte Lineage Cells Obtained from Meningeal Biopsy
Frontiers in Pharmacology, 2017 Oligodendrocyte loss can lead to cognitive and motor deficits. Current remyelinating therapeutic strategies imply either modulation of endogenous oligodendrocyte precursors or transplantation of in vitro expanded oligodendrocytes.
Sissi Dolci +15 more
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Oligodendrocyte lineage cells and depression
Molecular Psychiatry, 2020 Depression is a common mental illness, affecting more than 300 million people worldwide. Decades of investigation have yielded symptomatic therapies for this disabling condition but have not led to a consensus about its pathogenesis.
Butian Zhou +3 more
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Oligodendrocytes in the aging brain [PDF]
Neuronal Signaling, 2021 Abstract More than half of the human brain volume is made up of white matter: regions where axons are coated in myelin, which primarily functions to increase the conduction speed of axon potentials. White matter volume significantly decreases with age, correlating with cognitive decline.
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Frontiers in Molecular Neuroscience, 2017 Recently, it is reported that monocarboxylate transporter 1 (MCT1) plays crucial role in oligodendrocyte differentiation and myelination. We found that MCT1 is strongly expressed in oligodendrocyte but weakly expressed in oligodendrocyte precursors (OPCs)
Qingwei Lai +12 more
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Frontiers in Neurology, 2021 Multiple sclerosis (MS), the most prevalent inflammatory disease of the central nervous system (CNS), is characterized by damaged to myelin sheaths and oligodendrocytes.
Yukino Miyachi +15 more
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Autophagy collaborates with apoptosis pathways to control oligodendrocyte number
Cell Reports, 2023 Summary: Oligodendrocytes are the sole myelin-producing cells in the central nervous system. Oligodendrocyte number is tightly controlled across diverse brain regions to match local axon type and number, yet the underlying mechanisms remain unclear. Here,
Tingxin Zhang +9 more
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