Results 101 to 110 of about 86,512 (250)

NSD2 Coordinates the Neurogenic‐to‐Gliogenic Transition via H3K36me2‐Dependent Activation of the EGFR‐ERK Pathway

Advanced Science, EarlyView.
NSD2 coordinates the neurogenic‐to‐gliogenic transition in the developing neocortex through H3K36me2‐dependent activation of EGFR–ERK signaling. Loss of NSD2 disrupts astroglial and oligodendroglial development, whereas ERK activation rescues gliogenic defects in vitro and in vivo.
Hanxue Chen, Mengyuan Li, Lin Hou, Bin Yin, Boqin Qiang, Ran Gao, Pengcheng Shu, Xiaozhong Peng   +7 more
wiley   +1 more source

Inflammatory microglia correlate with impaired oligodendrocyte maturation in multiple sclerosis

Frontiers in Immunology
IntroductionRemyelination of demyelinated axons can occur as an endogenous repair mechanism in multiple sclerosis (MS), but its efficacy varies between both MS individuals and lesions. The molecular and cellular mechanisms that drive remyelination remain
J. Q. Alida Chen, Dennis D. Wever, Niamh B. McNamara, Morjana Bourik, Joost Smolders, Jörg Hamann, Jörg Hamann, Inge Huitinga, Inge Huitinga   +8 more
doaj   +1 more source

Influence of oligodendrocytes on neuronal network activity [PDF]

Myelination of axons is an important function of oligodendrocytes. This highly complex process is influenced by a multitude of factors, not all of which are known, let alone completely understood.
Schüssler, Michael
core   +1 more source

Aberrant GRP78 Phase Transition Sustains Endothelial IRE1α Signaling and Drives Blood–Brain Barrier Failure in Cerebral Amyloid Angiopathy

Advanced Science, EarlyView.
Vascular Aβ40 corrupts GRP78 phase behavior in brain endothelial cells, sustaining IRE1α–TRAF2–JNK signaling and driving apoptosis, tight junction loss, and blood–brain barrier failure in cerebral amyloid angiopathy. Pharmacological IRE1α inhibition restores vascular integrity, reduces leakage, and improves functional outcomes, revealing a targetable ...
Honglin Zheng, Qiang Li, Haiyang Luo, Yapei Yuan, Na Zhang, Yongting Lu, Suying Duan, Jieshi Zhong, Hang Zhang, Chenyang Liu, Yaochong Zhang, Wenzhuo Zhao, Yaxuan Song, Tuo Wang, Si Yan, Yapeng Li, Han Liu, Yuan Gao, Zongping Xia, Yuming Xu   +19 more
wiley   +1 more source

Innate Immune Responses in Human Oligodendrocytes

, 2019
The central nervous system (CNS) is comprised by the brain, spinal cord, and optic nerves, which are vital for normal bodily functions. Microglia and astrocytes are the CNS cells that contribute to homeostasis although excessive immune activation of ...
Saito, Leina Bernadette
core   +1 more source

ICOS‐ImmunoPET Monitors T Cell Activation After Combination Immune Checkpoint Blockade in a Mouse Model of Melanoma Brain Metastasis

Advanced Science, EarlyView.
ICOS‐immunoPET noninvasively visualizes activated T cells in melanoma brain metastases following combined anti‐PD‐1/anti‐CTLA‐4 therapy. Clinical translation of this imaging approach may improve patient stratification and treatment monitoring and serve as a quantitative imaging endpoint to support immunotherapy development and clinical trials in brain ...
Renesmee C. Kuo, Rohit Verma, Sydney C. Nagy, Mausam Kalita, Samuel Aubert, Josué Ballesteros‐Álvarez, Pedro Machado Almeida, Hannes Vogel, Israt S. Alam, Michael Lim, Michelle L. James   +10 more
wiley   +1 more source

Human oligodendrocytes in dissociated cell culture.

, 1989
Human oligodendrocytes have been successfully maintained in cell cultures for 14 weeks using a modification of a method used previously for animal brain cell cultures.
Meier C, Kesselring J, Rihs F
core   +1 more source

Endothelial YAP Signaling Promotes Blood‐Spinal Cord Barrier Repair in Mice After Spinal Cord Injury

Advanced Science, EarlyView.
Endothelial YAP is required for blood‐spinal cord barrier repair after spinal cord injury. YAP‐dependent vascular repair is associated with ANGPT1/PI3K/AKT signaling in vivo and may involve endothelial‐pericyte paracrine interactions. By supporting vascular remodeling, tight junction restoration, restored pericyte coverage, and astrocyte‐vascular ...
Jiawei Wang, Yaozhi He, Yanjiao Wang, Jingjing Zhang, Qishun Liang, Mengxian Jia, Yumin Wu, Zongjie Yuan, Ziwei Fan, Yuxuan Li, Huihui Zhang, Qinjiao Fu, Ying Wang, Zhihui Huang, Honglin Teng   +14 more
wiley   +1 more source

Functional Role of DDR1 in Oligodendrocyte Signaling Mechanism in Association with Myelination and Remyelination Process in the Central Nerve System

Journal of Physiological Investigation
Multiple sclerosis (MS) is a complicated, inflammatory disease that causes demyelination of the central nervous system (CNS), resulting in a variety of neurological abnormalities.
Mariadoss Arokia Vijaya Anand, Kumar Shivamadhaiah Manjula, Chau-Zen Wang   +2 more
doaj   +1 more source

Efficient derivation of oligodendrocytes from marmoset ESCs.

, 2012
(A) Protocol for derivation of NS/PCs from marmoset ESCs, which efficiently generate oligodendrocytes. EBs were cultured in the presence of 1×10−6 M RA and 2 µM purmorphamine for 2 weeks.
Toshihiro Nomura (121816), Ikuo Tomioka (121813), Hiroko Shimada (121794), Hayao Ebise (121806), Takuji Maeda (121819), Michisuke Yuzaki (121827), Masaya Nakamura (121832), Yohei Okada (121798), Erika Sasaki (121830), Kazuhisa Kohda (121822), Hideyuki Okano (47690), Shin-ichi Ota (121809), Keiji Ibata (121802)   +12 more
core   +1 more source