Results 101 to 110 of about 81,187 (302)

The unfolded protein response in multiple sclerosis

Frontiers in Neuroscience, 2015
The unfolded protein response (UPR) occurs in response to endoplasmic reticulum (ER) stress caused by the accumulation of unfolded or misfolded proteins in the ER.
Wensheng eLin, Sarrabeth eStone
doaj   +1 more source

Oligodendrocytes in Alzheimer's disease pathophysiology

Our understanding of Alzheimer's disease (AD) has transformed from a purely neuronal perspective to one that acknowledges the involvement of glial cells. Despite remarkable progress in unraveling the biology of microglia, astrocytes and vascular elements,
Kedia, Shreeya, Simons, Mikael
core   +1 more source

Composition‐Aware Cross‐Sectional Integration for Spatial Transcriptomics

Advanced Intelligent Discovery, EarlyView.
Multi‐section spatial transcriptomics demands coherent cell‐type deconvolution, domain detection, and batch correction, yet existing pipelines treat these tasks separately. FUSION unifies them within a composition‐aware latent framework, modeling reads as cell‐type–specific topics and clustering in embedding space.
Qishi Dong, Zijian Huang, Xuanwu Wang, Zhenghui Feng, Wei Liu, Bingding Huang   +5 more
wiley   +1 more source

The mGluR5 agonist CHPG enhances human oligodendrocyte differentiation

Acta Neuropathologica Communications
Previous studies in adult mice indicate that the mGluR5 agonist 2-chloro-5-hydroxyphenyl glycine (CHPG), reduces cuprizone-elicited losses in myelin. This effect is partly mediated by CHPG binding to mGluR5 receptors on reactive astrocytes, triggering ...
Yangyang Huang, Celine Geywitz, Anjalika Bandaru, Ian A Glass, Birth Defects Research Laboratory, Lucas Schirmer, Hiroko Nobuta, Cheryl F Dreyfus   +7 more
doaj   +1 more source

Two-Step Generation of Oligodendrocyte Progenitor Cells From Mouse Fibroblasts for Spinal Cord Injury

Frontiers in Cellular Neuroscience, 2018
Oligodendrocyte progenitor cells (OPCs) are attracting attention as the ideal cell therapy for spinal cord injury (SCI). Recently, advanced reprogramming and differentiation techniques have made it possible to generate therapeutic cells for treating SCI.
Yukyeong Lee, Yukyeong Lee, C-Yoon Kim, Hye Jeong Lee, Hye Jeong Lee, Jae Gon Kim, Dong Wook Han, Dong Wook Han, Kisung Ko, James Walter, Hyung-Min Chung, Hans R. Schöler, Hans R. Schöler, Young Min Bae, Kinarm Ko, Kinarm Ko, Kinarm Ko   +16 more
doaj   +1 more source

Using Oligodendrocytes for studies in Alzheimer disease

, 2022
Background Genomic regulatory architecture (GRA) has been primarily studied in European ancestry. As part of the functional Consortium of the Alzheimer Disease Sequencing Project, we are determining the GRA in African and Amerindian ancestries ...
Young, Juan J, Muniz, Maria, Farid Rajabli, Fulai Jin, Kunkle, Brian W., Jeffery M. Vance, Liyong Wang, Ramirez, Aura M, Jihanne J Shepherd, Shaina A Simon, Oron, Oded, Liu, Xiaoxiao, Oded Oron, Nuytemans, Karen, Griswold, Anthony J., Juan J Young, Ana Sofia Moura, Simon, Shaina A, Wang, Liyong, Dykxhoorn, Derek M., Hussman Institute for Human Genomics, Maria Muniz, Derek M. Dykxhoorn, Marina Lipkin Vasquez, Anthony J. Griswold, null null, Shepherd, Jihanne J, Vance, Jeffery M., Aura M Ramirez, Vasquez, Marina Lipkin, Rajabli, Farid, Jin, Fulai, Brian W. Kunkle, Karen Nuytemans, Moura, Ana Sofia, Xiaoxiao Liu   +35 more
core   +1 more source

The 9th International RASopathies Symposium

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT The RASopathies are a group of congenital disorders with overlapping clinical manifestations that are caused by pathogenic germline or early somatic variants that result in the hyperactivation of the RAS/mitogen‐activated protein kinase (MAPK) signaling pathway.
Pau Castel, Lisa Schoyer, Beth Stronach, Raya Bogdanova, Anton M. Bennett, Jaishri Blakeley, Miriam Bornhorst, Tammy Bowers, Saskia M. Brachmann, Emma Burkitt‐Wright, Kathryn Chatfield, Alessandro De Luca, Khalil El‐Chammas, Abdul Elkadri, John E. Fortunato, Bruce D. Gelb, Anne Goriely, Karen Gripp, Kassidy Grover, Lindsay Homan, Kenneth A. Kern, Maija Kiuru, Charles (Chuck) Lawson, Yong‐Seok Lee, Frank McCormick, Gina Ney, Cristina Nuevo‐Tapioles, Sara Pardej, Elizabeth I. Pierpont, Julia Plank, Nancy Ratner, Katherine A. Rauen, J. Elliott Robinson, Les Rogers, Sarah E. Sheppard, Keir Shiels, David Stevenson, Dagmar Tiemens, Matthew Traylor, K. Nicole Weaver, Marielle Yohe, Tamar Green   +41 more
wiley   +1 more source

Oligodendrocytes damage in Alzheimer's disease

, 2005
Research on Alzheimer's disease (AD) focuses mainly on neuronal death and synaptic impairment induced by beta-Amyloid peptide (A beta), events at least partially mediated by astrocyte and microglia activation. However, substantial white matter damage and
Ramírez, G, Alarcón, R, von Bernhardi, R, Roth, AD   +3 more
core  

Research progress on biomarkers of traumatic brain injury

Animal Models and Experimental Medicine, EarlyView.
Traumatic brain injury: From primary insult to secondary neuroinflammation and degeneration. Abstract Traumatic brain injury (TBI) is a common disorder of the nervous system and has become a leading cause of death and disability worldwide, imposing a substantial burden on patients and their social circles. Its main symptoms include dyskinesia, language
Xuting Shen, Si Cheng, Shuyi Chen, Mengyue Wang, Tangying Li, Weicheng Xu, Yifan Zhang, Ping Yuan, Lei Shi   +8 more
wiley   +1 more source

Inflammatory microglia correlate with impaired oligodendrocyte maturation in multiple sclerosis

Frontiers in Immunology
IntroductionRemyelination of demyelinated axons can occur as an endogenous repair mechanism in multiple sclerosis (MS), but its efficacy varies between both MS individuals and lesions. The molecular and cellular mechanisms that drive remyelination remain
J. Q. Alida Chen, Dennis D. Wever, Niamh B. McNamara, Morjana Bourik, Joost Smolders, Jörg Hamann, Jörg Hamann, Inge Huitinga, Inge Huitinga   +8 more
doaj   +1 more source